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urgent! If you can't get the nine-valent and four-valent "cervical cancer" vaccine, do you want to hit the domestic bivalent vaccine?

The importance of HPV vaccination is presumably familiar to good friends who have been concerned about Zhimei for a long time.

Cervical cancer is already the second largest tumor disease in mainland women, and among many cancers, it is currently the only cancer that can determine the cause and prevent it in advance.

The state is already vigorously promoting the universalization of cervical cancer vaccination. However, in many places, quadrivalent and nine-valent vaccines have appeared in the situation of "one injection is difficult to find".

Waiting for a long time, or failing to get about the quadrivalent and nine-valent vaccines, what to do? Do I want to get the bivalent vaccine?

First of all, let's talk about the conclusion: there is no need to cling to the 9 valence, the principle of vaccination is "early vaccination, early protection, early benefit".

Instead of expecting quadrivalent and nine-valent vaccines that are not easy to make an appointment, it is better to get the bivalent vaccine that can be delivered first, and protect yourself from now on.

urgent! If you can't get the nine-valent and four-valent "cervical cancer" vaccine, do you want to hit the domestic bivalent vaccine?

1

The protection rate of domestic vaccines is high and the adverse reactions are small

Many people are worried that domestic bivalent vaccines are not as effective as other vaccines in terms of protective efficacy, and this doubt can be dispelled as soon as possible.

According to the clinical trial analysis report [1,2], the performance of domestic vaccines in clinical trials is remarkable:

● In terms of preventing HPV16 and type 18-related precancerous lesions, the protection rate is comparable to that of foreign quadrivalent and bivalent HPV vaccines;

● In terms of efficacy in preventing persistent HPV16 and 18 infections, the protection rate is comparable to that of foreign quadrivalent and bivalent HPV vaccines, and the adverse reactions are mild.

2

The price of domestic bivalent vaccines is more "close to the people"

The domestic bivalent HPV vaccine is also much cheaper than the imported vaccine (the total cost of 3 injections is only more than 1,000 yuan).

Don't think "expensive is good". The price of domestic bivalent vaccines is close to the people, mainly because of the different production technology systems.

● Domestic HPV vaccine uses E. coli production technology, the cost is relatively low, so the price is more economical.

● Imported HPV vaccine adopts Saccharomyces cerevisiae production technology system, which is more expensive.

However, no matter what kind of production technology, it is registered and approved by the State Food and Drug Administration, and it is trustworthy.

urgent! If you can't get the nine-valent and four-valent "cervical cancer" vaccine, do you want to hit the domestic bivalent vaccine?

3

The production capacity of domestic vaccines is high and the supply is sufficient

The domestic "E. coli factory" has the advantages of low cost, fast production speed and high output. Therefore, many provinces and cities and areas of immunization program vaccination, but also use the domestic bivalent vaccine.

In addition, for girls aged 9 to 14 years old, only 2 injections are needed to achieve the same preventive effect as 3 injections for adults, which is more cost-saving and worry-free.

urgent! If you can't get the nine-valent and four-valent "cervical cancer" vaccine, do you want to hit the domestic bivalent vaccine?

At present, domestic HPV vaccines can be booked in most areas, and Zhimei has sorted out several appointment methods for everyone, and can be selected at will as needed:

● Make an appointment at the local vaccination clinic and CDC;

● Make an appointment on the official APP or WeChat public account of the local hospital;

● Go to the community health service center or health center to which the place of residence belongs for consultation and appointment for vaccination;

● Call the 12320 health hotline in various places to inquire.

In general, the safety of HPV vaccine is very high, whether it is a domestic vaccine or an imported vaccine, everyone can be assured of vaccination, early vaccination and early prevention.

urgent! If you can't get the nine-valent and four-valent "cervical cancer" vaccine, do you want to hit the domestic bivalent vaccine?

01, have been vaccinated with bivalent, tetravalent, still want to vaccinate nine valence can be?

Not necessarily.

At present, these three types of vaccines can play a preventive effect after vaccination, and repeated vaccination is of little significance [3].

However, if you insist on vaccination, you can get a higher-priced vaccine one year after completing the bivalent vaccination procedure if you meet the vaccination indications.

02. After vaccinating one or two doses of bivalent and quadrivalent vaccines, can the second and third doses be given with nine valence?

It should be as consistent as possible, without clinging to the nine-valent [4].

03, the child is now between 9 and 15 years old, should the bivalent or quadrivalent vaccine be given first, or wait until the child is 16 years old to receive the nine-valent vaccine?

Early vaccination is better than late vaccination.

Studies have shown that regardless of which of the three vaccines is administered, the vaccine stimulates two times as many antibodies as women aged 9 to 15 years [5].

In other words, the same vaccine is more effective in protecting younger women.

Instead of expecting the "probably better" protective efficacy of the nine-valent vaccine in the future, it is better to get it as early as possible and feel at ease as soon as possible.

Again, compared to vaccines that may work in the future, it is a good vaccine that can be hit in the body now to protect you. Early vaccination, early benefit.

More questions about hpv vaccine,

You can refer to the following article

No nonsense! How to play the "cervical cancer vaccine", the most complete answer is in this article

Reviewer

Lu Xuexin | Assistant researcher and doctor of immunology at the Institute of Viral Disease Prevention and Control, Chinese Center for Disease Control and Prevention

bibliography

[1] Wang Huaqing, Wang Yan, Wang Wanghua, Wang Yamin, Sun Xiaodong, Xu Disha, Li Mingzhu, Li Yan, Li Zhi, Yu Wenzhou, Yu Yanqin, Yue Chenyan, Zhang Xiaosong, Guo Xin, Hu Shangying, Zhao Fanghui, Zhao Chao, Zhao Yun, Qin Ran, Xia Changfa. Expert Consensus on Immunoprophylaxis of Papillomavirus-related Diseases in Cervical Cancer and Others (Simplified Edition)[J].Chinese Journal of Vaccines and Immunology,2019,25(06):718-735.

[2] Wei L,Xie X,Liu J,et al. Efficacy of quadrivalent human papillomavirus vaccine against persistent infection and genital disease in Chinese women: A randomized, placebo-controlled trial with 78-month follow-up[J]. Vaccine,2018,364:401-411

Wu Chan,Zhou Huaijun,Li Mei. Interpretation of the "Committee Opinion on HPV Vaccination of the American Association of Obstetricians and Gynecologists"[J]. Chin J Obstetrics & Gynecology,2017,5(52): 354-357

Tang Rongchun,Xu Rui,Yao Ranran,Yu Shuangshuang,Liang Jiawei,Zhang Jun. Research status and progress on the safety and efficacy of HPV vaccine[J].Infectious Disease Information,2020,33(04):358-362.

[5]https://www.uptodate.cn/contents/zh-Hans/human-papillomavirus-vaccination?search=HPV&source=search_result&selectedTitle=2~150&usage_type=default&display_rank=2#H1664119832

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