The interaction between endothelial cells and fat cells is fundamental to maintaining the balance of white adipose tissue (WAT), as elucidated by the activation of angiogenesis when WAT dilates, a process that can be damaged during obesity, however, researchers currently know little about the molecular mechanisms of crosstalk between endothelial cells and fat cells.
Recently, in a research report published in the international journal Nature Metabolism entitled "Angiocrine polyamine production regulates adiposity", scientists from the Josep Carreras Institute and other institutions found that the abundance and function of blood vessels in adipose tissue determine the occurrence and progression of obesity.
Image source: https://pubmed.ncbi.nlm.nih.gov/35288722/
Obesity is a multifactorial epidemic disease, which is related to a variety of diseases derived from the intensification and expansion of adipose tissue, the development of preventive and therapeutic strategies for this disease is urgently needed in biomedical research; adipose tissue has an important blood supply demand, and so far researchers have not elucidated the important role of blood vessels in the process of obesity, for this reason, researchers Graupera et al. analyzed the regulatory mechanism and function of blood vessels through research. Relevant studies were carried out using genetically engineered animal models.
In order to elucidate the important role of blood vessels in the process of obesity, the researchers conducted a study of mouse models with enhanced vascular function and observed that mice will tolerate obesity; so the researchers knew that blood vessels may indicate the body's control of fat management, based on this, the researchers focused on how to identify the molecular mechanism of crosstalk between blood vessels and fat tissue, which is a scientist who had to turn to cancer research to understand the reasons for the obesity process.
Years of scientific research have led to the conclusion that blood vessels use a language of communication based on small molecules or metabolites to guide adipose tissue, and that fat cells respond to information from blood vessels and release fat, which blood vessels capture as food for proliferation; however, paradoxically, blood vessels produce these metabolites in the same mechanisms we recently described in the context of prostate cancer; when blood vessels activate this process during periods of controlled proliferation increase, Tumor cells do this in an uncontrolled and abnormal way.
Image credit: Josep Carreras Leukaemia Research Institute
This study reveals the importance of blood vessels in regulating the body's heart and disease, historically, blood vessels have been considered to be the body's inert vascular transport pipeline, but researchers have found that they may be able to sense changes in the body and respond by regulating and assembling the function of various tissues; in fact, blood vessels respond differently in each organ, which may indicate that we are facing a very special tissue in our entire body. This provides a very important opportunity to improve the health of the body by regulating the function of blood vessels. In summary, the results of this paper show that vascular endocrine metabolic signals may be very important for the balance of white adipose tissue and the metabolism of the body.
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