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Overview of the condition
Mr. Wang is a veteran friend who has been treating for more than 7 years! We follow up and publish his case every year, and 2021 has passed, has his situation changed?
Eight years ago, Mr. Wang's younger brother fell ill with lung cancer. Despite also undergoing surgery and chemotherapy, he still left his loved ones a year later.
Mr. Wang was devastated. After dealing with his brother's aftermath, Mr. Wang was physically and mentally exhausted and worried that he had hereditary nature, so he went to the hospital for a physical examination.
However, God really did not give him a bit of luck - Mr. Wang was also diagnosed with lung cancer!!
And the degree of malignancy is even higher than that of the younger brother! Is multicenter origin invasive adenocarcinoma!
The double blow plunged the entire family into a fog of misery.
In August 2014, Mr. Wang underwent surgery immediately after being diagnosed with lung cancer. Postoperative pathology: invasive adenocarcinoma, acinar dominant type, moderate differentiation, positive vascular invasion, positive pleural invasion; (right upper lung) invasive adenocarcinoma, papillary dominant, low differentiation.
Popular science trivia
What is "polycentric origin" invasive adenocarcinoma?
Although Mr. Wang's tumors in the right upper lung and pleura are both adenocarcinomas after surgery, the two nodules are of different natures, and it is considered that they may be double primary cancers - that is, two cancers at the same time, which is a very rare situation. Among them, the tumor in the pleura is a low-differentiation adenocarcinoma, and low-differentiation adenocarcinoma indicates that there may be a poor prognosis. The degree of differentiation in pathological typing reflects the degree of malignancy of the tumor. Cancerous changes in normal cells generally occur in the process of transformation from stem cells to normal cells, the lower the degree of differentiation, the closer the tumor cells are to stem cells and the greater the difference from normal cells, the stronger their ability to divide, the stronger the ability to mutate, self-repair, and anti-chemotherapy radiotherapy. Conversely, high differentiation indicates that tumor cells are more similar to normal cells, which means that the degree of malignancy of the tumor is relatively low and the possibility of metastasis is relatively small.
However, patients with lung adenocarcinoma have one more treatment than patients with lung squamous cell carcinoma - targeted therapy. After the operation, Mr. Wang did not take chemotherapy, but after genetic testing, he found that he had an EGFR mutation and took gefitinib targeted drug therapy for 4 months.
Mr. Wang is still not at ease after timely surgical treatment and targeted therapy. Violation of the vasculature is mentioned due to pathology. Vascular violation is a high-risk factor. Usually, the tumor grows in a way that infiltrates deep into the tissue, and the invasion of the deep vasculature by the tumor suggests that cancer cells enter the vascular network, and it is in this way that the tumor cells leave the primary lesion and metastasize to other sites, so there is a greater risk of recurrence later on.
Mr. Wang was still not at ease. After many understandings, Mr. Wang and his family learned about Professor Zhang Minghui's NKT technology by Professor Zhang Minghui of Tsinghua University School of Medicine through the recommendation of friends, and consulted the demonstration cases of NKT cell therapy in detail, especially hoping to try to reduce the risk of tumor recurrence and delay the time of recurrence/metastasis.
After reading Mr. Wang's medical records, Professor Zhang Minghui made the following analysis and judgment:
1. The patient undergoes radical resection immediately in the early stage of tumor development, and the postoperative stage is earlier. Taking targeted drugs for 4 months after surgery is very positive for prognosis, but targeted drugs have the disadvantage of drug resistance and cannot completely eliminate recurrent metastasis.
2. Early postoperative staging is good news, but the type of vascular invasion and differentiation of pathological results still suggests a greater risk of relapse and metastasis. Even if there are currently no tumors that can be detected by imaging, there is no guarantee that there will be no recurrence of metastasis. How to consolidate the "achievements" of the early stage requires the search for another effective treatment - cellular immunotherapy.
3. NKT treatment is the use of powerful immune cells to kill those tumor cells that may remain in the body and cannot be discovered, and there are basically no side effects, which is very friendly to patients. Maintain systematic long-term stability with NKT cell therapy after completion of conventional therapy.
Mr. Wang decided to adopt NKT cell immunotherapy in September 2014, the initial protocol was 1 course/month, and after multiple follow-up visits, no signs of recurrence and metastasis were seen, and the treatment frequency was downgraded to 1 course/2 months. After 6 consecutive follow-up evaluations without any signs of relapsed metastasis, it has now been adjusted to 1 course/half year.
As of July 2021, 32 courses of treatment have been completed for a total of 82 months.
Imagery
There was no significant change from September 2017 to December 2021; there was no significant change in the subpleural ground glass micronodular shadow of the upper lobe of the left lung, and there was no significant change from November 2014 to December 2021. There was no significant change in the lower lobe of the left lung near the pleura, and there was no significant change from 2014.11 to 2021.12, and the overall evaluation was stable.
Swelling aspect
CYFRA21-1 was slightly above normal on February 27, 2017, and the rest were in the normal range; SCC was intermittently elevated from 2015.3 to 2016.7. 2021-5-18,2021-12-8CYFRA21-1 and TPSA are higher than normal. 2021-12-8NSE is higher than normal.
quality of life
Mr. Wang's quality of life has been greatly improved. Appetite improved significantly compared to before treatment, mental state was very good, returning to the state before illness. Normal work and life, not affected by illness.
Conclusion
Mr. Wang's situation is actually very common, and many patients think that surgery can be done once and for all, ignoring the higher risk of recurrence such as poor pathological typing and vascular invasion. NKT cell immunotherapy plays an integral role in reducing the risk of relapsed metastasis, not only destroying residual tumor cells, but also strengthening the immune system. In the 32 courses of treatment that were constantly changing and adjusting in 82 months, Mr. Wang repeatedly reviewed and evaluated the stability, and the overall mental and physical level was systematically improved.
Popular science knowledge, for reference only, individual patients are subject to clinical treatment.