Hello everyone, I am Dr. Zeng Hongbo of the Le Qisheng-Liu Xiangyuan fetal protection team. There are many reasons why fetal arrest occurs, and if repeated fetal arrests occur, it is necessary to do a full set of detailed examinations
Guangzhou Infertility Hospital
Common causes of fetal arrest:
Causes of fetal arrest include chromosomal abnormalities in the embryo itself, or routine abnormalities in the man's semen, or uterine malformations, endocrine, or immune-related abnormalities in the woman.
In the early stages of pregnancy, if there is embryo closure, many of them are caused by chromosomal abnormalities in the embryo itself, and the chromosome examination of the embryo can be done to determine it. If it is found that the embryo itself has triploids, or other chromosomal abnormalities, the reason for the embryo's cessation can be determined.
Once it is determined that the embryo is stopped, it is recommended to terminate the pregnancy as soon as possible, otherwise it is easy to cause coagulation dysfunction in the mother, resulting in heavy bleeding and so on.
If the embryo is stopped repeatedly, it may be an endocrine or immune-related factor, and it is necessary to actively do a full set of detailed examinations, only to find out the real cause of the pregnancy, after symptomatic treatment can help the next pregnancy go smoothly.
What tests to do for fetal stoppage:
If there is an occasional fetal stop, it is a kind of survival of the fittest. In this case, there is generally no need to do special examinations, but if there are two or more consecutive fetal stops, it is called recurrent miscarriage, and a detailed examination is needed at this time.
The chromosomal abnormalities of the embryo itself are a common cause of embryo cessation, and clinically it is first necessary to check whether the chromosomes of both husband and wife are abnormal, and it is necessary to conduct karyotype analysis for the aborted embryos to determine whether the embryos are stopped due to karyotype abnormalities.
Pregnant women with endocrine disorders or other major medical conditions may also cause embryos to be cut off. Pregnant women are clinically asked whether they are accompanied by a major illness or are in the acute phase of an infectious disease.
In addition, it is clinically necessary to check the endocrine of pregnant women, that is, to check whether the pregnant woman's progesterone is normal, whether there is insufficient luteal function, and whether there is an autoimmune disease, because autoimmune diseases can also lead to embryonic abortation. Tests for immune factors, such as the presence of blocking antibodies, are also required.
What are the fetal stop immune tests?
There are many causes of fetal arrest, and immune factors are important reasons for not being able to conceive normally, or being prone to fetal arrest after pregnancy, so it is best to do immune tests when the fetus stops.
1. Antiphospholipid syndrome and thrombosis project: Antiphospholipid antibody is a specific autoantibody produced by its own glycerol phospholipid components.
2. Thyroid function items: many women have hypothyroidism or hyperthyroidism, and will also lead to recurrent miscarriage due to abnormal thyroid function.
3. Blood type and blood type antibody examination: the blood type of both husband and wife is incompatible, especially the mother of type O blood is prone to recurrent spontaneous abortion.
4. HLA gene examination.
5. Blocking antibody: the lack of blocking antibody is also one of the important reasons for repeated spontaneous abortion.
6. Anti-reproductive immune antibodies include anti-sperm antibodies, anti-endometrial antibodies, anti-ovarian antibodies, anti-chorionic gonadotropin antibodies, anti-nuclear antibody profiles (including ANA, ENA and ds-DNA, etc.) and anti-zellucida antibodies.
7. TB lymphocyte subset and natural killer cells (NK), immune cells and complement, interleukin 2 interferon and tumor necrosis factor, etc.
Guangzhou fetal protection doctor introduction: Le Qisheng - Zeng Hongbo
Guangzhou fetal protection doctor Zeng Hongbo
Dr. Zeng Hongbo- As a member of Liu Xiangyuan's fetal protection team, Dr. Zeng Hongbo is good at using the combination of traditional Chinese medicine and Western medicine to diagnose and treat common gynecological diseases, multiple diseases and intractable diseases, and has rich experience in the diagnosis and treatment of immune infertility, recurrent miscarriage, menstrual disorders, etc.