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Previously on December 8, 2021
The NmPA also approved it
Tengsheng Huachuang's new crown neutralizing antibody drug registration
Neutralizing the principle of action of antibody drugs
The structure of the new crown virus is very simple
It's a layer of protein shell
Encased in genetic material RNA
Small crown-like bumps on the shell
It's called protein S
Coronavirus is full of bad water
Thinking all the time—
But cell factories are not easy to enter
It has a wall called the cell membrane on the outside
There is a large number of "guards" outside the city walls
Guard the entrances everywhere
These "guards"
The technical term is called "receptor"
Only substances that are recognized by them
to be allowed
If the new crown virus has not been able to find a way
Into the cells
It will be Game Over
Unfortunately
There's a "guard" called ACE2.
Confused by the "crown of the new crown"
The full name ACE2 is angiotensin-converting enzyme 2
It is a protein that is usually involved in the regulation of blood pressure in the human body
Coronavirus Crown (S Protein)
There is a part of the substance that looks like the one needed for ACE2
Therefore, he was mistaken by ACE2 as his own person
A small hand leads the wolf into the room
Principles of neutralizing antibody drugs
It is to inject the body with a preferred neutralizing antibody
This antibody recognizes and envelops the crown of the new crown virus
So
ACE2 does not recognize the coronavirus
Automatically block it out of the cell walls
The neutralizing antibody then further damages the viral particles
Neutralize them
Tengsheng Huachuang was approved for marketing of neutralizing antibody drugs
That's it
It is a combination therapy drug
It is injected into the body by means of drips
After one injection
Neutralizing antibody concentration in the blood
It can be achieved 300 times that inhibit the growth of 90% of the virus
According to the State Food and Drug Administration
This medicine is used in the treatment
Light and normal and accompaniment
Adults who progress to a high risk factor for severe and
Adolescent patients (12-17 years, weight ≥40 kg)
Principle of action of small molecule oral drugs
If it is said to neutralize antibody drugs
It is used to prevent the virus from entering the cell
That small molecule oral drug
It is used to disrupt virus replication plans
After the virus enters the cell factory
The outer protein shell will dissolve
Releases genetic material RNA
Then, the RNA will do whatever it takes to sneak in
The command center of the cell factory , the nucleus
To the "hit workers" in the factory
Issue an incorrect command
"Hit workers" in various departments of the cell factory
After receiving the instruction
Regardless of three seven twenty-one
Start doing it
In this way, the cell factory becomes a virus factory
An army of viruses was produced
Then proceed to infect other healthy cells
Currently the mainstream small molecule oral drug
There are two kinds of working logic:
One logic is
The drug contains some substances
It looks a lot like parts of the coronavirus
When assembling parts in "hit workers"
These substances are also mixed in
Eventually assembled into a fake virus
Merck COVID-19 oral drug Molnupiravir
This type of drug is in the face of viral mutations
There are certain advantages
Another logic is
The drug contains an ingredient
Can make the "hit worker" in key positions
Passive sabotage or even strikes
The production line that directly causes the virus to replicate is paralyzed
Today the conditional emergency was approved for import
Pfizer COVID-19 oral drug Paxlovid
It's this kind of medicine
This medicine from Pfizer
Can be used to treat adults
With high-risk factors for progression to severe disease
Mild to moderate patients
For example, with advanced age, chronic kidney disease,
Diabetes, cardiovascular disease, chronic lung disease,
patients with high risk factors for severe illness
I have medicine, can I take off my mask?
The new crown special drugs are currently approved by emergency
Some are conditionally approved
In addition, the new crown virus is extremely easy to mutate
Long-term effects
Especially side effects, etc
It remains to be observed
So prevention is still important
"COVID-19 Vaccine + Mask + COVID-19 Special Drug"
It is also the best combination of COVID-19 prevention and control at present
In addition to the above has been approved
Outside of the new crown special drug
There are also many new crown drugs at home and abroad
It is under development
The progress is as follows:
China Securities News and China Securities Taurus reporters sorted out according to the research report and the announcement of listed companies
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Reporter: Fu Suying, Guo Jiying, Wang Zhuying, Roger
Editor: Zhang Nan, Ye Song