1，Cell | What makes him "defend the territory"? What makes her "lick deeply"? Two cell types that depend on sex and estrus cycle were identified
Source: BioArt
Sex hormones have a profound effect on sex-dependent sexual behavior, and previous studies have identified many cell types defined by the transcriptome, but little is known about the expression of genes that differ in sex or estrus status. Recently, nirao M. Shah's team from Stanford University published an article in the journal Cell that identified 1415 genes that were expressed differently between sex or estrus status. This study suggests that there are a large number of different sex and estrus-dependent cell types in the mammalian brain, and the projection and function of these cells enable sex hormone-reactive groups to regulate different social behaviors.
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Cell | What makes him "defend the territory"? What makes her "lick deeply"? Two cell types that depend on sex and estrus cycle were identified
2, without chemical "labeling", use "sugar" to track stem cells in the brain
Source: Biocomm
Unlike most other cells, mannose residues (green) are abundant on the MSC cell membrane, and it is now possible to track transplanted mesenchymal stem cells using mannose-sensitive nuclear magnetic resonance imaging techniques
Since mammalian cells often lack high sugar content, injecting stem cells that naturally contain a lot of sugar may be easily detected against the background of brain tissue. Jeff Bulte's team from Johns Hopkins University found that certain self-renewing stem cells with built-in tracers — made from sugar — were injected into mouse brains without the need to add chemical "labels" to do the job. Their study, published recently in Nature Biomedical Engineering, found that mesenchymal stromal cells contain high levels of mannose, which is similar to glucose, and can be easily and successfully detected by standard imaging methods based on magnetic resonance imaging (MRI). Another new study they published in Nature Communications shows that certain tumor cells, after losing large amounts of sugar molecules that are easily detected by mriorimetry, develop the behavior of using sugar as a tracer.
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Without the need for chemical "labels", stem cells in the brain are tracked with "sugar"
3，STTT | Wang Yan/Bian Xiuwu/Lu Shengqing of the Army Military Medical University have discovered a potential new treatment for glioblastoma
Source: iNature
Analysis of the TCGA database and in vivo mouse models provides substantial evidence that platelet-derived growth subunit A (PDGFA) plays a key role in the development of glioblastoma (GBM). So far, only platelet-derived growth receptor α (PDGFRA) have been identified as receptors for PDGFA. However, in the TCGA_GBM database, PDGFA and PDGFRA are classified as different molecular subtypes of GBM. Recently, Wang Yan, Bian Xiuwu and Lu Shengqing of the Army Military Medical University jointly published a research paper online at Signal Transduction and Targeted Therapy. The study provides new insights into the function of PDGFA and reveals EPHA2 as a potential receptor for PDGFA. EPHA2 may be involved in PDGFA signal transduction in conjunction with PDGFRA and mediate resistance of GBM cells to PDGFRA inhibitors. Therefore, the combination of inhibitors targeting PDGFRA and EHA2 represents a promising GBM therapeutic strategy.
STTT | Wang Yan/Bian Xiuwu/Lu Shengqing of the Army Military Medical University have discovered a potential new treatment for glioblastoma
4, JPD: What is the relationship between smoking marijuana and Parkinson's?
Source: New Frontiers of Nerves
Parkinson's disease (PD) is the second most common neurodegenerative disease. Tremor is one of the common motor symptoms of PD. Studies have shown that activation of cannabinoid receptors can improve tremor in animal models. Activation of cannabinoid 1 (CB1) receptors inhibits the release of glutamate and regulates the overactivity of adjacent neurons, thereby reducing tremors. Researchers from Australia recently published a study in JPD investigating cannabis treatment in patients with PD and found no convincing evidence to recommend the use of cannabis in patients with PD. However, cannabis has found potential benefits in relieving PD-related tremors, anxiety, pain, improving sleep quality and quality of life. Given the relatively low number of well-designed randomized studies, it was determined that further investigation was needed.
JPD: What does marijuana smoking have to do with Parkinson's?
5, scientific research achievements | How does parental psychological control affect teens' problem phone use?
Source: Prosocial Lab
The dangers of teens addicted to mobile phones are well known, but why are teens so obsessed with mobile phones? What does problem phone use have to do with their upbringing? What is its psychological mechanism? A study recently published in the Journal of Child and Family Studies answers these questions. Studies have found that parental psychological control may predict problem cell phone use in teens. Teenagers whose basic needs are unmet or frustrated in real life may turn to virtual games and social media in mobile phones to compensate, which in turn leads to mobile phone addiction.
Scientific research results | How does parental psychological control affect teens' problem phone use?
6, JPD: hydrophobic statin drugs, or may accelerate Parkinson's progression
Parkinson's disease (PD) is a progressive neurostructive disease of nerve rods. There is an urgent need to develop new and/or disease-altering PD treatments. Statins are thought to have a neuroprotective effect. Previous epidemiological studies have focused on the incidence of statins and PD, and the results have been inconsistent. The effect of statins on clinical PD progression has received less attention. Recently, Mechelle M. Lewisa et al. studied the potential effects of statins on the progression of PD. The study found that the overall use of statins or lipophilic statins did not significantly affect the clinical or imaging progression of PD compared with non-statin users. Hydrophilic rather than lipophilic statins may be associated with the rapid progression of PD.
JPD: Hydrophobic statins may accelerate Parkinson's progression
7, back to work! What kind of people would be more proactive in their work? | Cell Press Paper Express
Source: CellPress Cell Science
After the Spring Festival, there will inevitably be fatigue in the work. Do you know what kind of people would be more proactive in their work? A recent study published in Heliyon provides useful advice for human resource managers. According to the study from Indonesia, people who are proactive, more satisfied with their work, and more confident in themselves are more likely to push themselves to get their work done and take the initiative to take on more responsibilities.
Back to work! What kind of people would be more proactive in their work? | Cell Press Paper Express
8, how to make AI more "human"? MIT Research: This is critical
Source: Academic Headlines
As more and more technology is evolving, machines are interacting with us in more natural ways of communicating, with voice-user interfaces (VUIs) being a major way to achieve social interaction. When voice assistants have become the standard for tech giants, the next step is to bring family members closer to the AI assistant.
Recently, a new study from the MIT Media Lab showed that if the digital assistant exhibits some human-like social behavior, users will be more likely to trust this new VUIs. More precisely, the more social behaviors VUIs exhibit, the more consistent with human intelligence and habits, the more likely people are to trust it and interact with it. The findings were published in the journal Frontiers in Robotics and AI.
How to make AI more "human"? MIT Research: This is critical
Reviewer: Simon
Caption: Photo Network
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