It may not be long before the "human body 4S store" becomes a reality? Recently, the world's first "pig heart human transplantation" experiment was successful, and David Bennett, a 57-year-old heart patient, was reborn after successfully implanting a gene-edited pig heart.
01 After 7 hours, the pig heart was successfully transplanted to a person
It is reported that the pig heart used in this experiment is not the same as that on our table, but a gene-edited pig. The team at the University of Maryland School of Medicine first knocked out 4 genes that may cause human rejection and continued growth, and then implanted 6 human genomes to ensure its tolerance to the human immune system. In order to ensure the vitality of the heart, it is only taken out of the pig a few hours before the operation and escorted by a professional medical crisper box, and after 7 hours, it is put into the human body.
At present, it has begun to work normally, producing pulse blood and no rejection has occurred. Professor Bartley P. Griffith of the University of Maryland said, "The success of this experiment brings us one step closer to solving the problem of organ transplantation. Previously, the Langone Medical Center of New York University has also successfully completed the experiment of gene editing pig kidney transplantation to human beings, and the success of pig hearts has undoubtedly added hope to the realization of "pig organ human transplantation".
(Professor Griffith (left) and Bennett (right))
On the eve of New Year's Day, the FDA has approved the application through expanded access, which means that if the experiment can be fully successful, that is, no rejection will occur within a few months, pig organ transplantation may be used on a large scale in the future, and the shortage of human organs will also be solved in a new way.
02 Next, Human Body 4S Shop?
With the success of pig heart and pig kidney transplantation to human experiments, some professionals said that since the heart, liver, lungs, and kidneys can be replaced if they are broken, then with the maturity of gene editing technology, we can also establish a human body 4S shop like a car, and repair and replace it after 70 or 80 years. In this way, you can break the time limit of the genes in the body and survive for a long time. In December 2018, Zhang Yu, a well-known entrepreneur, has taken the lead in announcing that he will invest 6 billion yuan to build a "human body 4S store" in Chengdu, hoping that in the future, he can use a little less cost to achieve the goal of not getting sick and getting sick, and then prolonging a healthy life span of 120.
However, if you just want to extend a healthy life, from the current level of technological development, it may be far from using such a dangerous and tortuous method as the human 4S store. In terms of the gene editing technology used to modify pig hearts alone, in December 2020, Harvard professor David Sinclair successfully restored the animal's vision lost due to aging through gene editing. The study also appeared on the cover of Nature under the name "Back in Time." At the same time, it also found in the study that a natural substance of niacinamide mononuclear dry acid (the core ingredient of the net red supplement "Perovir Pro") had the same effect.
In the experiment, this substance successfully reversed the state of the elderly laboratory animals to the young adult stage, and changed the international biological aging indicators, including cellular mitochondrials, telomeres, etc., to a relatively young state, and the overall healthy survival time was extended by 2 to 30%. In recent years, since the derivative "Palovie Pro" has been settled in Beijing Cat and other ways, it has also received the attention of many celebrities and rich businessmen, even Hong Kong's richest man Lee, real estate tycoon Pan's and so on are one of the fans of such technologies.
03 Is the great burst of science and technology ushering in a leap in life expectancy?
In recent years, with the rapid development of science and technology, various technologies that promote the leap in human life expectancy have emerged. However, as far as organ transplantation is concerned, in addition to being achieved through gene editing pigs, Professor Dai Jianwu, director of the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences and the director of the Regenerative Medicine Research Center, and his team have also developed a series of functional biological materials that can specifically combine regeneration factors and stem cells, helping to solve the key technology of organ regeneration microenvironment. Now they have successfully helped dozens of "stone girls" to successfully become mothers.
At the same time, scientists from Israel have also discovered that a microbaric oxygen chamber similar to O2 ark can also increase the dissolved oxygen content in the organism, accelerate blood circulation, and help the organism maintain healthy function. In a regular experiment with 60-year-olds, after 3 months their cell levels and telomeres, etc., were 25 years younger. Now after such technology has been developed and landed by the high-speed rail Victall Rail Company, it has not only settled in the Winter Olympic training ground, but also landed in Yangpu, Shanghai, causing a new wave of high-net-worth people to maintain health trends.
The "Palovie Pro" anti-aging technology previously discovered by Harvard professor David has also been confirmed by the university of Washington, Keio University, Sichuan University and other world-class top scientific research institutions in recent years, and has now been included in the key research projects of The relevant departments of Japan, and it is planned to use it to solve their increasingly serious aging problems.
The Harvard professor once said in his book "Can We Not Grow Old" that "we can't think of it as a disease just because all people will age." No one wants to grow old sadly. The development of modern science and technology may allow us to overcome aging at the end of this century. "Now it seems that we are closer to this day.