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01 Vertigo, tinnitus, hearing loss associated with Meniere's disease

1.1

Adult (domestic usage)

▎1.1.1 Indications

Used to treat vertigo, tinnitus, and hearing loss associated with Meniere's disease (Meniere's syndrome)[1].

▎1.1.2 Dosage

■Tablets:

The starting dose is 4 mg three times daily, preferably with meals, adjusting the dose according to age and symptoms, with a maximum daily dose of 48 mg[1].

Usually, adults take 1-2 tablets (betatastine mesylate 6-12 mg at a time) three times a day, orally after meals, depending on age and symptoms [3].

■Oral liquid:

take orally. 10-20 mg (half-to-1) three times a day [5].

■Injection:

Intravenous infusion. 500 ml (0.02 g with betahistine hydrochloride and 4.5 g sodium chloride) once daily, infused slowly intravenously, or as directed by a healthcare practitioner [6].

02 Vascular headache

2.1

▎2.1.1 Dosage

Limit 1 to 2 tablets (4-8 mg) 2 to 4 times daily, with a maximum daily dose of 48 mg [2].

03 Vertigo, tinnitus and hearing loss caused by cerebral arteriosclerosis

3.1

▎3.1.1 Indications

Vertigo, tinnitus, and hearing loss due to cerebral arteriosclerosis [4-7].

▎3.1.2 Dosage

take orally. 10 to 20 mg at a time, 30 to 60 mg a day, and a maximum of no more than 60 mg per day [4].

Intravenous infusion. 500 ml (0.02 g with betahistine hydrochloride and 4.5 g sodium chloride) once daily, infused intravenously slowly, or as directed by a healthcare practitioner [6-7].

04 Ischemic cerebrovascular disease

4.1

▎4.1.1 Indications

It is used to treat acute ischemic cerebrovascular diseases such as cerebral thrombosis, cerebral embolism, and transient cerebral insufficiency [2].

It has the effect of dilating cerebral blood vessels, heart blood vessels and peripheral blood vessels. Can be used to treat ischemic cerebrovascular disease [4].

Orthostatic vertigo and tinnitus due to ischemic cerebrovascular disease [5-7].

▎4.1.2 Dosage

Intravenous infusion. 500 ml once daily (containing betahistine hydrochloride 0.02 g, sodium chloride 4.5 g) infusion slowly intravenously. or as directed by a physician [6-7].

05 Orthostatic vertigo and tinnitus caused by hypertension

5.1

▎5.1.1 Indications

Orthostatic vertigo and tinnitus due to hypertension are also effective [2][5-7].

▎5.1.2 Dosage

06 Vertigo

6.1

▎6.1.1 Dosage

Adults usually take 1-2 tablets (betatastigmine mesylate 6-12 mg at a time) orally three times a day after meals, depending on age and symptoms [3].

Intravenous infusion. 500 ml (0.02 g with betahistine hydrochloride and 4.5 g sodium chloride) once daily, infused intravenously slowly, or as directed by a healthcare practitioner [7].

07 Medication for special populations

7.1

Children's Usage

The safety effectiveness of this product in children has not been established [1].

This trial was not conducted and there are no reliable references [3].

Not for children [4-7].

7.2

Elderly usage

Caution is taken to monitor and adjust the dose[1][4][7].

In general, because the physiological and metabolic functions of the elderly are reduced, it is necessary to pay attention to reducing the dosage[3][5][6].

7.3

Medication during pregnancy

There are no sufficient data on the use of betahistine in pregnant women. There are insufficient animal studies on the effects of this product on pregnancy, embryonic/fetal development, childbirth and postpartum development. The potential risk to humans is unknown, and bevitalistine should not be used during pregnancy unless the benefit outweighs the risk[1].

Pregnant women and women who may be pregnant may be treated only if it is judged that its beneficialness outweighs the risks[3][4][7].

7.4

Medication during lactation

It is unclear whether betahistine is secreted from breast milk. At present, there is no study on whether this product is secreted from the milk of animals. Lactating women should decide whether to take the drug against the benefits of the mother and the potential risks to infants and young children [1].

Since the safety of administration during pregnancy has not been established, it is unclear whether this product can be excreted by breast milk, so pregnant and lactating women should use with caution [4-7].

bibliography:

[3] Drug information: Betahistine mesylate tablets, Sinopharm ZH20040130; 2007/11/14

[5] Drug information: betahistine hydrochloride oral solution, Sinopharm ZH H20066114;

[6] Drug information: betahistine hydrochloride oral liquid, Chinese medicine quasi-word H20056604;

First published: Clinical Decision Assistant

Author: Jie Xiao Yao

Editor-in-Charge: Little Dangdang

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