Obesity is one of the major health problems that plague modern humans. How to find a time-saving and labor-saving and safe way to lose weight is also a topic of concern for many scientific studies.
Drug weight loss is a way of losing weight. Since the new century, Europe and the United States have been approved to market a variety of new weight loss drugs, they have been used in the clinic for a period of time, in the end how effective, is there any drug Mu Xiu Yulin?
Just today, the authoritative medical journal Lancet published an article from the team of West China Hospital, which comprehensively analyzed a number of studies on weight loss drugs and tried to tell us the answer. As soon as the article came out, it triggered a heated discussion, and we will briefly introduce it to you.
Image source: Lancet
143 studies, 49810 participants pooled answers
The article is from the team at West China Hospital, but the study was not about obese people in China. After all, most of the new weight loss drugs are not approved for use in China.
They did a meta-analysis of network systematic reviews, found studies on weight loss drugs from a global database, and included 143 studies based on the criteria, involving a total of 49,810 participants. With the help of these data, the effects of various diet pills are comprehensively analyzed.
The analysis was divided from the dimensions of "how many people can successfully lose weight", "how much can be the maximum weight loss", "what proportion of drugs are discontinued due to adverse reactions", and each drug is scored.
The final composite results showed that in addition to levocarnitine, the drugs included in the study achieved the goal of reducing people's weight by an average of 5%, and the overall evaluation was phentermine-topiramate, followed by smeglutide.
What exactly is Champion drug?
Phentermine-topiramate is a compound preparation, which is not listed in China, and can be used for weight loss treatment in the United States, but the requirements are also very strict, and it must not be used for overtime.
The two components of the drug are the sympathomimetic drug phentermine and the epilepsy treatment drug topiramate, the former can induce early satiety to suppress appetite, the latter for weight loss mechanism is unknown, but it was observed that it can increase the appetite-suppressing effect of phentermine, so a combination formulation was formed.
Smeglutide is a new type of GLP-1 receptor agonist, the job is to promote the release of insulin for long-term hypoglycemia treatment of diabetes, but because of the discovery of good weight loss effect, so in the United States has been approved as a simple weight loss drug, no diabetes can also be used.
Although the score of smeglutide is slightly inferior in this study, it will be regarded as the first choice of drugs in many learning weight loss recommendations. China has recently approved the use of smegglutide as a diabetes treatment, but the indications do not currently include simple obesity without diabetes.
Important Reminders/Important Reminders/Important Reminders:
The studies we see today do not serve as guidelines for weight loss drugs.
The study came from the Chinese team, but the drugs did not comply with Chinese regulations and could not be used legally. In terms of drug weight loss, the domestic policy is relatively conservative and pays more attention to drug safety. Today's research may serve as a guide for future drug policy.
Weight loss is a cure. Only when obesity is obvious and poses an important health hazard, is it worth it to risk adverse drug reactions to receive treatment. If the conditions for obvious obesity are not met, receiving medication is not enough to get along with the body. Thinking of being fat is not necessarily a disease that needs to be treated.
For example, the use of phentermine-topiramate, in addition to general constipation, dry mouth and other adverse reactions, there are also a few serious problems such as cognitive impairment and mental abnormalities.
Don't harm your body, don't illegally buy weight loss drugs that are not approved in China, don't listen to what slimming food and health products, the use of illegally added weight loss supplements to cause tragedies has happened many times.
If you do have significant obesity (BMI over 30), or if obesity is complicated by complications such as diabetes, and you are unable to achieve weight loss through standard diet and exercise control lifestyle interventions, then consult a doctor and choose other weight loss methods such as compliant drugs in China.
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