"The joints are not good? Eat some ammonia! ”
But all friends with bad joints may have more or less heard the words "ammonia sugar" and "glucosamine"!
For the majority of patients with knot-related diseases, ammonia sugar can be said to be a star product!
However, for its efficacy, whether it is a patient or a doctor, there is a more extreme evaluation, some think it is useless, some think that its efficacy is exact, why is this happening? Should I eat this ammonia sugar?
Today we will peel off the cocoon, break it open for everyone, crush it, and have a good chat!
Ammonia sugar, what the hell is it?
Glucosamine, in the final analysis, is a substance that exists in our body itself, it participates in the production of many substances in our body, participates in the construction of a variety of tissues and cell membranes of our human body, the reason why glucosamine has become a star product for the treatment of joint diseases, mainly stems from one of its roles, that is, the synthesis of joint cartilage and synovial fluid molecules in the intermediate products, some studies found that ammonia sugar can promote the production of joint synovial fluid, naturally play a role in lubricating joints, And ammonia sugar is also involved in the synthesis of a particularly important substance in the joint called hyaluronic acid, many of our joint patients for intra-articular injection of sodium hyaluronate for osteoarthritis, this sodium hyaluronate is hyaluronic acid.
Seeing that glucosamine has such a good effect, do you think it is likely to play a good role in our joints?
The answer is really not like this! There is still a lot of controversy about whether glucosamine is useful for joints, and some studies have proved that ammonia sugar is useful for joint treatment, and some studies have proved that ammonia sugar plays a placebo role in joint treatment.
It is precisely because of this controversy, so now the attitude of various countries to ammonia sugar is not the same, some countries define glucosamine as health care products, some countries define glucosamine sulfate as drugs, and the current situation in our country is that health care products and drugs are available.
Ammonia sugar is controversial cause
There are several reasons for this.
The first reason is that we all know that glucosamine itself does have a certain effect on the joints, but it is only one of the components of joint cartilage, and what kind of role it will play on the overall joints needs to be further studied. Just like we all know that calcium is a very important component of our bones, but whether calcium supplementation can be absorbed into the bones and whether it can be deposited on the bones is another story.
The second reason, our oral amino sugar, after being absorbed by the body into the bloodstream, can it reach a certain concentration and be used by our body?
Here to introduce a new concept called slow-acting osteoarthritis treatment drug (SYSADOA), we should know that the main pathological change of osteoarthritis is the wear and tear of cartilage in the joint, which eventually leads to a large number of osteophytes forming joint stenosis, which is an important reason for the dysfunction and disability of many elderly people.
For different stages of osteoarthritis treatment, there are different stages of treatment options, and in the early stage of osteoarthritis treatment, this class of drugs has a very important role, there are studies showing that the use of drugs of this type of drug can reduce the dosage of anti-inflammatory analgesic drugs by 36% to 50%, so that the risk of drug side effects, such as the risk of digestive tract, the risk of bleeding and the risk of cardiovascular accidents, especially for people older than 75 years old, have some chronic diseases, or have had cardiovascular accidents Patients at risk of renal side reactions are relatively safe.
This class of drugs includes diacetorein, avocado-soy saponifications, some plant extracts, and of course glucosamine.
The ammonia sugar in this is not the glucosamine sulfate or glucosamine hydrochloride that we all know, but a special glucosamine, called crystalline glucosamine sulfate (pCGS).
Studies have shown that taking ordinary glucosamine to get a blood concentration of only 1.2 μM, and taking crystalline glucosamine sulfate once a day 1500 mg can achieve a steady-state blood concentration, up to 9 μM, to know that there are studies showing that glucosamine in the optimal plasma concentration needs to reach about 10 μM, in order to inhibit the induction of interleukin (inflammatory response), can help us control the pathobiological expression of osteoarthritis and tissue destruction.
From this data, we can also understand that the glucosamine you take has no effect, and it is likely that the corresponding blood concentration has not been reached, so it does not play a real role.
The third reason, this one has an artificial factor. For unknown reasons or reasons that everyone may understand, the efficacy of glucosamine has been exaggerated excessively, so suitable and unsuitable people will be recommended to take ammonia sugar, a large number of people who are not suitable for taking glucosamine, and people who have worn out osteoarticular cartilage are very serious, and the efficacy is naturally very poor, or has no effect.
Here to make it clear to you, ammonia sugar its main role in the cartilage, such as some bone and joint very serious patients, joints have been deformed, X-ray shows that the joint space is significantly narrow, nuclear magnetic shows that cartilage wear is very serious, and even has a meteorite-like change, then this situation, eating ammonia sugar will not play any role, this is like we must have soil in the field, sprinkle seeds to grow seedlings, then if there is no land, even if you sprinkle more seeds, there will be no harvest.
Seeing this, after you understood the controversy over ammonia sugar, Dr. Xie told you whether you should eat this ammonia sugar or not, and how to take it?
Ammonia sugar, should I eat it? How to take it?
Although ammonia sugar has a certain controversy, but in the clinic there are some early and intermediate osteoarthritis patients, after taking ammonia sugar joint symptoms have improved, some patients even have a great improvement, the following is a little advice for you to take ammonia sugar, I hope to help you:
● Choose the indications: This is the basis of whether ammonia sugar can work, it is recommended that you have abnormal sensations such as joint pain, discomfort, soreness, etc., which has caused trouble to your life, it is recommended to go to the hospital for X-ray or MRI examination, to clarify the wear and tear of joint cartilage, whether there is a narrowing of the joint space, when the problem is light, the effect of taking ammonia sugar is good.
● The time to take: the onset of ammonia sugar is relatively slow, we do not think that eating it on the joint will be immediately relieved, that is analgesic, it does not belong to the ammonia sugar this type of drug. Therefore, it is recommended to take ammonia sugar for about three months, if the symptoms of taking after this period of time have improved significantly, you can continue to take it after a period of rest, if there is no joint improvement in oral administration for three months, then you do not need to take it again.
● Pay attention to the choice of categories: ammonia sugar variety of brands or a lot, it is recommended that you can choose glucosamine sulfate, the stimulation of the gastric mucosa is relatively small, if you can find crystalline glucosamine sulfate will be better. In addition, it is recommended that you choose the ammonia sugar of the medicinal word.
● Pay attention to the details during the medication: Some people will form irritation to the gastric mucosa after taking ammonia sugar, if you have unbearable stomach pain when taking ammonia sugar, please stop the drug in time. The preparation of ammonia sugar is mainly extracted from shellfish substances, so if you are allergic to seafood, you must pay attention to whether there are allergic symptoms such as rashes during taking, and once allergic, stop the drug in time.
● Dosage problem: In the first half of the article, Dr. Xie has mentioned that it is recommended to take crystalline glucosamine sulfate, and to take 1500 mg at a time, so that the absorption of the drug will be better and the bioavailability is the highest (depending on your drug instructions).
● Can diabetics take ammonia sugar: This needs to be read by everyone, and the instructions for you to buy ammonia sugar depend on its composition. Under normal circumstances, diabetics can safely take ammonia sugar, although it is called ammonia sugar, but it will not affect blood sugar.
Other measures to control arthritis
Here Dr. Xie would like to say to you:
"Ammonia is not a lifesaver for saving joints!"
Taking glucosamine has certain indications, not all patients will be effective, and for the treatment of osteoarticular problems, ammonia glucose is an auxiliary measure, it does not play a decisive role.
All attempts to solve complex problems through a simple measure are wrong.
When you have joint pain, please be sure to pay attention to going to the hospital for the corresponding examination, to determine what degree your joints have reached, according to the doctor's advice, choose scientific and reasonable medication, of which glucosamine is only a small part of the treatment.
In daily life, we must also pay attention to the need to strictly control weight, to have a scientific and reasonable diet, and to carry out scientific and reasonable exercise and rehabilitation exercises, so that we can play a multi-pronged approach, in order to play a comprehensive system role, to help us fight against bone and joint problems (if you are very concerned about what kind of diet, what kind of exercise can better fight against bone and joints, please pay attention to Dr. Xie, look for Dr. Xie's previous popular science articles, which have a detailed introduction).
summary
In general, ammonia sugar is useful for some patients, we do not use ammonia sugar as a life-saving straw, nor should we demean the uselessness of ammonia sugar, for suitable patients, it can still play a certain role.
It is recommended that you can try to take ammonia sugar to alleviate your joint symptoms according to the doctor's advice, what kind of ammonia sugar to take specifically, in the front of the article has been given a detailed introduction, if you have other doubts can leave a message below, let's discuss together.
I am insisting on using simple language to explain the knowledge of complex diseases Xie Xinhui, code words are not easy, if you agree with my point of view, please help to pay attention to or like it, if you or your family and friends also have bone and joint problems, do not know whether to take ammonia sugar, please forward this article to friends who need it, help them point out the mystery, thank you!