One Reader, who is more unprofessional than medicine, | Tongzi
On March 11, 2021, Guo Meimei, a first-generation Internet celebrity who had recently been released from prison, was criminally detained by the public security organs on suspicion of selling slimming products containing the banned ingredient sibutramine.
Sibutramine is an adjuvant treatment for weight loss, which produces appetite suppression through the nerve center, and may produce adverse reactions such as thirst intolerance, headache, insomnia, rapid heartbeat, and memory loss after taking.
Before 2010, many diet pills on the market contained sibutramine, the most famous of which was Qumei, which Fan Bingbing once endorsed.
Foreign clinical studies have found that the use of sibutramine may increase the risk of various cardiovascular diseases, and in severe cases, it may even lead to death.
In October 2010, the State Food and Drug Administration issued a notice to completely stop the production, sale and use of sibutramine in China, and in 2012, it included sibutramine in the "List of Substances That May Be Illegally Added in Health Foods". In 2016, the Food and Drug Administration issued the "Food supervision of the Food and Drug Administration Iii [2016] No. 68", once again for the treatment of illegally added products such as sibutramine.
However, there are still unscrupulous merchants in the market, peddling slimming products containing sibutramine.
Therefore, sibutramine does have a weight loss effect, but it is no longer a drug recognized by the State Food and Drug Administration. So, do friends who want to lose weight have a reliable choice?
Yes! However, the "efficacy" of diet pills recognized by the State Food and Drug Administration may surprise everyone.
Legal diet pills that leak oil and spray oil
Orlistat is currently the only over-the-counter diet pill approved and approved by the State Food and Drug Administration, and the principle of weight loss is also very magical, which can send the fat in food "intact" out of the body.
It is well known that water and oil are incompatible. Orlix, he tells you, and oil are not compatible.
A single capsule of orlistat with a human meal will become a walking "grease separator", no matter what is eaten, it is excrement and oil that is pulled out.
This is due to orlix's unique inhibitory effect on lipase in the gastrointestinal tract.
The human body can not digest the fat in food, with the help of lipase, the fat is decomposed into fatty acids and glycerin before digestion and absorption.
When a person eats orlistat, the lipase in the gastrointestinal tract is bound by orlistat. Fat is not decomposed by lipase, it will not be absorbed by the human body, flowing freely in the human gastrointestinal tract, and finally successfully escaped from the body.
Robin et al. (heavenly flying) cos food fat, stone monster cos lipase, Sauron (three-bladed green haired swordsman) cos orlistat
But the limited number of bowel movements in a day can not meet their needs, and those who are eager to escape from the body of the oil, do not talk about martial arts, do not let go of any chance of escape, they will spew out with the fart, occupy your panties, outer pants, even the sofa...
If you can slim down successfully, chrysanthemum greasy can also be tolerated. However, for many people, the results are not directly proportional to the effort.
Usually orlistat can only prevent about 30% of the fat from being absorbed by the body at a time, accumulating into a lot, and can also make people suffer from 3 to 4 kg in a few months. For many people who are eager to lose weight, the results of 3 to 4 kg are too watery, no way, after all, orlistat can only inhibit the absorption of dietary fat in the gastrointestinal tract, which has no effect on the fat that has been stored in the human body.
When regular diet pills let people leak oil and spray oil due to the "weight loss gains" of 3 to 4 kg for several months, some drugs that treat other diseases play an excellent "weight loss side effect".
Drugs that do not cure obesity but are good at losing weight
There are heart-planted flowers that do not bloom, and there is no heart to plant willows. Some patients with hyperlipidemia accidentally "lie thin" after taking statins.
Hyperlipidemia is one of the killers of human health, and arterial plaques can form life-threatening in the later stages. Statins are currently the most effective lipid-lowering drugs in the world, which can not only effectively reduce total cholesterol and low-density lipoprotein, but also reduce triacylglycerol to a certain extent, so it is also known as "comprehensive lipid adjusting drugs".
Some netizens have a "lying thin" record of 3 months and 15 pounds, and asked the doctor on the Internet for reasons, of course, the doctor is impossible to admit.
Doctors think with their fingers to know what the consequences will be
It turns out that statins do have a great weight loss effect. On May 7, 2020, a study published in the British journal Nature found that statins have a certain effect on the intestinal flora of obese patients, inhibiting the "Bacteroides type 2 (bact2)" that causes intestinal dysfunction.
The prevalence of "Bacteroides 2" is 3.9% in lean people and 17.7% in obese patients. Among obese patients taking statins, the prevalence of "Bacteroides 2" dropped to 5.9%. To this end, the team of scientists will also conduct further research to determine the specific effects of statins on the gut microbiota of obese patients.
In addition to "comprehensive lipid-regulating" statins, metformin, which treats diabetes, is also in the field of weight loss (bu) performance (wu) hui (zheng) huang (ye).
Clinical trials have shown that patients with type 2 diabetes who receive metformin therapy lose an average of 2 to 3 kg of weight. After all, the hypoglycemic principle of metformin is indeed conducive to weight loss, can reduce postprandial blood sugar by improving the use of glucose by peripheral tissues, and can also inhibit the absorption of glucose in the small intestine and reduce excess fat synthesis.
A study in the United States believes that metformin can delay or even reverse the progression of diabetes mellitus in patients with high sugar (abnormal glucose tolerance). Metformin is currently available throughout type 2 diabetes. In the United States, a prospective study of diabetes has found that metformin can reduce the incidence of cardiovascular disease in addition to lowering sugar. Other studies have found that metformin can significantly inhibit tumor growth.
But this "miracle drug" also experienced a delisting storm in France. Metformin was launched in France in 1957 and gradually spread in other European countries. Due to the adverse reactions of some patients in the treatment, metformin was recommended to be delisted and was not marketed again until 1995.
Note: Friends with normal blood sugar should not try metformin, otherwise they may have dizziness, drowsiness, irritability, coma and other adverse reactions due to hypoglycemia, and even lead to death.
In 2020, the US Food and Drug Administration FDA once again "attacked" metformin, saying that some metformin drugs may cause cancer.
However, in the history of THE FDA for more than a hundred years, weight loss-related drugs have exuded a strong legend.
The legendary history of diet pills in the United States
Since the establishment of the FDA in 1906, there have been many bariatric drugs that have been certified and revoked before and after, some of which are short-lived and some of which are floating.
The earliest certified diet pills were actually a drug, amphetamines.
Amphetamine (amphetamine), also known as amphetamine (transliteration), synthesized from ephedrine derivatives by American chemist Gordon Alles in 1929, was originally used to treat nasal congestion, then turned to treat mild depression, "World War II" was used by soldiers as a "military food pill" to boost mood and increase vigilance, and later used by housewives to reduce appetite and weight. Because amphetamines hallucinate addicts and have withdrawal reactions, in 1971, amphetamines were included in the FDA drug control regulations.
It's not unusual to use drugs as diet pills, and Americans have also eaten explosives — dinitrophenol.
Around 1934, a diet pill called dinitrophenol (DNP) came out, achieving weight loss by accelerating metabolism, but in just four years, it became a banned drug in various countries. DNP was originally a material for making explosives, which is not only carcinogenic, but also fatal. Unlike other banned drugs, it is now illegal to take DNP in many countries, but it is not illegal to sell DNP, because DNP is also used as a chemical dye and pesticide.
After that, the FDA also certified and revoked many diet pills:
Phenylpropanolamine (approved in 1945, delisted in 2000)
◆ Fenmequ Qinphenmetrazine (approved in 1956, delisted in 1982)
◆ Mazindol (approved in 1973, delisted in 1982)
Fenfluramine (approved in 1973, delisted in 1997)
◆ Sibutramine, (approved in 1997, delisted in 2010)
In the "harem" of the FDA's diet pills, there is a person with deep qualifications that has gone through several ups and downs, and it is the phentermine approved by the FDA in 1959.
Phentermine is the longest-lived diet pill in U.S. history, but its supremacy is often shaken. Diethylamine benzophenone threatened its position in the 1970s, and was stolen by benzomorpholine in the 1980s. In the early 1990s, phentermine and fenfluramine (that is, the previous fenfluramine delisted in 1997) "joined forces" to form a "fenfen" combination, with a surprising weight loss effect of 13.6kg per capita, regaining its dominant position.
In September 1997, the FDA stopped the "fenfen" combination because of a 31.6% chance of heart valve disease in people taking "fenfen". Because there were no complaints of serious adverse reactions caused by phentermine alone, phentermine was able to continue to be sold in the United States.
This paragraph refers to the diet pill life book
From the history of the development of diet pills, it can be seen that those drugs that make people "lie thin" may make people lie down and die. Obesity is not good for health, but excessive weight loss can make people mentally and physically unhealthy.
Please truly love life and stay away from drugs, explosives and diet pills...
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snell-bergeon j k . diabetes: cardiovascular benefits of metformin in t1dm[j]. nature reviews endocrinology, 2017, 13(10):565-566.
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