Rice blast caused by rice blast bacteria is the most serious and devastating disease of rice, which occurs not only in all parts of the world, but also has the potential to occur at all reproductive stages of rice. Recently, the research group of Zhang Zhengguang, College of Plant Protection, Nanjing Agricultural University, has revealed the mechanism of histone acetyltransferase-mediated autophagy to control the pathogenesis of rice blast bacteria.
Previous studies have shown that after the conidia of the rice blast fungus contact the rice and identify the surface of the rice leaves, the tip of the bud tube where the spores germinate produces an infective structure - attachment cells, which form a huge expansion pressure inside, breaking through the rice epidermis to form an infection.
Zhang Zhengguang's team found that histone acetyltransferase family genes were highly expressed in the early stages of rice infestation by rice blast bacteria (plospathogens, 2015). Recent studies have further found that when the bacteria grow vegetatively, histone acetyltransferase mohat1 is highly phosphorylated and localized in the nucleus, and after the bacteria contact and recognize rice, part of mohat1 continues to remain in the nucleus, while the other part is rapidly dephosphorylated, binds to the heat-excited protein mossb1, and enters the cytoplasm with its help, acetylation of the core proteins moatg3 and moatg9 in autophagy to achieve precise regulation of autophagy. In addition, the formation of functional attachment cells of rice blast bacteria is controlled, and the bacteria are helped to complete the infection.
Recently, the authoritative journal "autophagy" (5-year impact factor 11.8) in the field of cell biology published Nannong's research paper on histone acetyltransferase-mediated autophagy control of functional attachment cell formation and pathogenicity of rice blast bacteria "histoneacetyltransferase mohat1 acetylates autophagy-related proteins moatg3 andmoatg9 to orchestrate functional appressorium formation and pathogenicityin magnaporthe oryzae”。 The first signatory unit of the paper is Nanjing Agricultural University, the first author is Yin Ziyi, a doctoral student of Nannong Plant Protection College, and Chen Chen, a master's student, and Professor Zhang Zhengguang of Nannong is the corresponding author. Professors Zheng Xiaobo and Haifeng Zhang of Nannong and Professor Ping Wang of Louisiana State University participated in the study.
Histone acetyltransferase mohat1 regulates the formation of functional attachment cells of blast bacteria
The study was the first to discover that histone acetyltransferase mohat1 phosphorylation/dephosphorylation determines its intracellular localization, and resolved the biochemical mechanisms that play a role in the cytoplasm, thus closely linking the autophagy of the pathogen with the formation and pathogenicity of functional attachment cells from the biochemical and molecular biological levels. It expands people's understanding of plant pathogenic fungi attack hosts, helps to understand the pathogenic mechanism of rice blast pathogens, and is expected to provide a reference for designing efficient and low-toxic rice blast control strategies. The project has been funded by key projects of the National Natural Science Foundation of China, innovation groups and Jiangsu Provincial Science and Technology Innovation Team.
In recent years, with the funding of national and provincial and ministerial projects, the research group has devoted itself to the research on the pathogenesis mechanism and control of rice blast bacteria, and has made a series of progress in identifying rice and monitoring and inhibiting the immune response of rice blast bacteria, in terms of plos pathogens, plos genetics, new phytologists, molecular plant-microbe interaction, and environmental Mainstream journals of pathogen biology and plant pathology, such as microbiology and molecular plant pathology, have published research results.
Copyright Notice: If copyright issues are involved, please contact the website with proof of ownership