The COVID-19 pandemic is a global wake-up call, and humanity may not be ready for a pandemic.
On November 3, at the World's Top Scientists Pandemic and Public Health Forum, Xie Xiaoliang, winner of the 2015 Alberni Biomedical Prize and Professor Li Shau Kee of Peking University, mentioned two technical research in response to the new crown pandemic: strengthening needles and new antibodies.
He said that as drugs are applied in the human body, they will be accompanied by the production of related antibodies and variants. Once the virus mutates, such drugs will not lose their full efficacy, but will greatly reduce the effectiveness, so the purpose of increasing the effectiveness of the vaccine can be achieved by strengthening the needle.
"Currently, the delta strain reduces the effectiveness of the synthetic antibody in the blood, and injecting an enhancer needle within six months after the second dose has become an important way to increase the effectiveness of the antibody." Xie Xiaoliang said.
In terms of drugs to deal with the new crown, the new crown virus neutralizing antibody as a drug, there are clinical data to support its efficacy on mild and moderate disease, but the data show that at least half of the neutralizing antibody drugs are difficult to effectively cope with the mutant strain, will be escaped by the mutant strain, it is difficult to achieve the desired effect.
Xie Xiaoliang introduced a very important neutralizing antibody, dxp-604, which provides new ideas for responding to the pandemic. He revealed that the dxp-593/dxp-604 neutralizing antibody pair developed by Danxu Biology, which he was one of the initiators, escaped by the mutant strain when used as a drug, but the antibody dxp-604 did not escape.
DXP-604 has also shown good efficacy in clinical trials, and Phase II clinical trials are currently underway. Xie Xiaoliang revealed that DXP-604 has been approved as a sympathetic treatment in Beijing Ditan Hospital, and as of November 2, 14 patients have received related treatment.
In addition, the current global impact of the COVID-19 pandemic has brought public interest in vaccines to an unprecedented level. However, some have expressed concern about vaccinations and even opposed them.
At the forum site, Harvey Alter, winner of the 2020 Nobel Prize in Physiology or Medicine, pointed out that in the past five years, in the United States and other parts of the world, the acceptance of science can be seen to show a sharp decline, especially during the new crown epidemic, the American public has shown a low acceptance of scientific knowledge.
Alter believes that the level of public science awareness should be improved, "in the long run, if the level of scientific awareness of the public as a whole is not raised, it will threaten more people's lives and even affect the maintenance of democracy." ”