An Lei is a professor at China Agricultural University and an expert in livestock embryonic development.
1. Research direction
With the goal of establishing the technology of efficient utilization of livestock gamete embryos, the research mainly studies the regulation mechanism of livestock gamete and embryonic development, focuses on the apparent regulatory mechanism of in vitro fertilization (IVF) embryonic development abnormalities, and breaks through the key technical bottlenecks of livestock in vitro embryo production.
An Lei is a professor at China Agricultural University and an expert in livestock embryonic development.
2. Teach courses
Undergraduate: Animal reproduction experiments
Master's degree: Animal Reproduction and Embryonic Engineering Technology Practice, Animal Molecular Reproduction and Development Theory, Animal Molecular Reproduction and Development Theory.
Third, study the resume
2000.09-2004.06: College of Animal Science and Technology, Shanxi Agricultural University, Bachelor of Agronomy;
2004.09-2010.06: College of Animal Science and Technology, China Agricultural University, Ph.D. in Agronomy.
Fourth, work resume
2010.07-2013.12: Lecturer, College of Animal Science and Technology, China Agricultural University;
2014.01-2018.11: Associate Professor, College of Animal Science and Technology, China Agricultural University.
2018.11-present: Professor, College of Animal Science and Technology, China Agricultural University.
5. Social part-time
Director of the Reproduction Branch of the Society of Animal Husbandry and Veterinary Medicine;
Reviewer for The Journal of Animal Husbandry and Veterinary Medicine, Journal of Animal Husbandry and Veterinary Medicine, Reproduction in Domestic Animals, Journal of Integrative Agriculture.
Old school gate of China Agricultural University
6. Scientific research projects
1. Natural Foundation project "Research on the key role of C-type sodium peptide in the initiation of preluminal follicle formation" (PI) 2017.01-2020.12
2. "863" project "Functional Genomics Research on Important Economic Traits in Sheep" (sub-topic) 2013.01-2017.12
3. Support program project "Pig and cattle breeding disorder control" (sub-project), 2011.01-2014.12
4. "863" project "Research on Animal Embryo Apparent Modification and Somatic Cell Cloning Technology" (participation), 2011.01-2015.12
5. National Natural Science Foundation of China, Molecular Mechanism of In Vitro Embryo Birth Sex Imbalance (Participation) 2015.01-2018.12
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VII. Thesis (# First Author, * Corresponding Author)
1、Tan K, An L#, Miao K, Ren L, Hou Z, Tao L, Zhang Z, Wang X, Xia W, Liu J, Wang Z, Xi G, Gao S, Sui L, Zhu DS, Wang S, Wu Z, Bach I, Chen DB, Tian J. Impaired imprinted X chromosome inactivation is responsible for the skewed sex ratio following in vitro fertilization. Proc Natl Acad Sci U S A 2016； 113: 3197-3202 (co-first author)
2、Tan K., Wang X., Zhang Z., Miao K., Yu Y., An L*., and Tian JH.*, Downregulation of miR-199a-5p Disrupts the Developmental Potential of In Vitro-Fertilized Mouse Blastocysts. Biol Reprod (2016, in press online)
3、Tan K, Wang Z, Zhang Z, An L*, Tian JH*. IVF affects embryonic development in a sex-biased manner in mice. Reproduction 2016； 151:443-53.
4、L. Tao, M. Yang, X. Wang, Z. Zhang, Z. Wu, J. Tian, L. An *, and S. Wang*, Efficient biallelic mutation in porcine parthenotes using a CRISPR-Cas9 system. Biochem Biophys Res Commun 476 (2016) 225-9.
5、Tan K, Zhang Z, Miao K, Yu Y, Sui L, Tian J, An L*. Dynamic integrated analysis of DNA methylation and gene expression profiles in in vivo and in vitro fertilized mouse post-implantation extraembryonic and placental tissues. Mol Hum Reprod 2016. 22； 485-98
6、Wei X, Xiaoling Z, Kai M, Rui W, Jing X, Min G, Zhonghong W, Jianhui T, Xinyu Z, Lei A*. Characterization and comparative analyses of transcriptomes for in vivo and in vitro produced peri-implantation conceptuses and endometria from sheep. J Reprod Dev 2016.
7、Sui L, An L#, Tan K, Wang Z, Wang S, Miao K, Ren L, Tao L, He S, Yu Y, Nie J, Liu Q, Xing L, Wu Z, Hou Z, Tian J*. Dynamic proteomic profiles of in vivo- and in vitro-produced mouse postimplantation extraembryonic tissues and placentas. Biol Reprod 2014； 91: 155. (co-first author)
8、Nie J, An L#, Miao K, Hou Z, Yu Y, Tan K, Sui L, He S, Liu Q, Lei X, Wu Z, Tian J*. Comparative analysis of dynamic proteomic profiles between in vivo and in vitro produced mouse embryos during postimplantation period. J Proteome Res 2013； 12: 3843-3856. (co-first author) 5
9、Wang, Y., Wang, C., Hou, Z., Miao, K., Zhao, H., Wang, R., Guo, M., Wu, Z., Tian, J., An, L*., 2013. Comparative analysis of proteomic profiles between endometrial caruncular and intercaruncular areas in ewes during the peri-implantation period. J Anim Sci Biotechnol 4, 39. 2
10、Pang YW, An L#, Wang P, Yu Y, Yin QD, Wang XH, Xin-Zhang, Qian-Zhang, Yang ML, Min-Guo, Wu ZH, Tian JH*. Treatment of porcine donor cells and reconstructed embryos with the antioxidant melatonin enhances cloning efficiency. J Pineal Res 2013； 54: 389-397. (co-first author) 5
11、An L#, Pang YW, Gao HM, Tao L, Miao K, Wu ZH, Tian JH. Heterologous expression of C. elegans fat-1 decreases the n-6/n-3 fatty acid ratio and inhibits adipogenesis in 3T3-L1 cells. Biochem Biophys Res Commun 2012； 428: 405-410. 3
12、Ma W, An L#, Wu Z, Wang X, Guo M, Miao K, Ma W, Tian J*. Efficient and safe recipient preparation for transplantation of mouse spermatogonial stem cells: pretreating testes with heat shock. Biol Reprod 2011； 85: 670-677. (co-first author) 10
13、An L#, Wu ZH, Wu YF, Zhang XL, Liu X, Zhu YB, Cheng WM, Gao HM, Guo M, Tian JH*. Fertility in single-ovulating and superovulated dairy heifers after insemination with low dose sex-sorted sperm. Reprod Domest Anim 2010； 45: e344-e350. 9
14、Cheng WM, An L#, Wu ZH, Zhu YB, Liu JH, Gao HM, Li XH, Zheng SJ, Chen DB, Tian JH*. Effects of disulfide bond reducing agents on sperm chromatin structural integrity and developmental competence of in vitro matured oocytes after intracytoplasmic sperm injection in pigs. Reproduction 2009； 137: 633-643. (co-first author) 9
8. Patents
1、Method for inducing twin calving. US 20140349934A1 (International Patent for Invention)
2. Application of C-type sodium peptide in promoting in vitro maturation of bovine oocytes ZL201210348285.9
3. Application of letrozole in the preparation of adult bovine superovulation drugs ZL201110436200.8
4. Application of letrozole in the preparation of hormone-induced follicle development drugs in calves ZL201110434833.5
5. ZL201220721931.7 of the end of a pig deep uterine low-dose spermation device and its sperm feeder
6. A method for preparing sex-controlled sperm of cows ZL201110059938.7
7. A method for digesting the zona pellucida of oocytes ZL200610012029.7
Emblem of China Agricultural University
9. Awards and honors
1. In 2011, he participated in the construction of the professional master's degree course "Progress and Practice of Animal Reproductive Technology" and won the excellent course at the university level;
2. In 2013, he participated in the construction of the "Livestock Reproduction" course and won the national high-quality resource sharing course;
3. From 2010 to 2014, he served as the class teacher of the 102nd class of the Dynamic Department, and the class successively won the titles of "Beijing Advanced Class Collective", "Excellent Study Style Class" and "Excellent League Branch" at the school level;
4. In 2014, he guided the undergraduate graduation design to obtain a university-level excellent thesis;
5. Outstanding Party Member of the College in 2015;
6. 2016 "Great Northern Agriculture Young Scholar Award".
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