Industry, academia and research use to blossom new flowers, innovative technology for development. Recently, the scientific research team of Renmin Peptide Group, Professor Wang Shaoyun of the School of Biological Sciences and Engineering of Fuzhou University, and the team of Wu Jinhong of the College of Agriculture and Biology of Shanghai Jiao Tong University jointly published the article "Research Progress on the Theoretical Mechanism of Antifreeze Protein and Ice-Water Interface Layer Interaction" in the domestic food professional and technical journal Food Science Journal [1]. Aiming at the theoretical problem of how AFPs regulate the structure of the ice-water interface layer, this paper analyzes and discusses several typical AFPs theoretical mechanism models, and reveals the principle of combination or interaction between AFPs and ice crystals by regulating the formation of ice-water interface layer structure and its driving force, so as to provide a theoretical reference for the in-depth analysis of the antifreeze activity mechanism of AFPs, its screening, and its application in the food industry. The research results fully demonstrate the people's state peptide group to deepen the integration of industry, education and research innovation strength, but also for the future development of the national peptide layout to lay a solid theoretical foundation!
Antifreeze proteins (AFPs), also known as ice structure proteins or ice binding proteins, are a class of proteins that control the growth of ice crystals and inhibit the recrystallization of ice crystals, and protect organisms from damage under ice or sub-icing conditions. The unique antifreeze activity of AFPs not only has a vital physiological effect on cryogenic organisms (such as cell structure), but also makes them have a wide range of application value in the fields of frozen food quality regulation, bacterial cryoprotection, plant frost protection, biomineralization, and medical organ transplantation.
Antifreeze protein has two special functional activities - thermostatic activity and recrystallization inhibition activity, the thermal hysteresis activity of AFPs is mainly manifested in the non-dependent reduction of the freezing point, FPs thermostatic activity is an important mechanism of ice crystal morphology regulation. Its unique antifreeze activity has been widely concerned. However, due to the complexity of its type and structure, how to regulate the structure of the ice-water interface layer in the freezing environment, and in what way it combines or interacts with ice crystals to achieve its inhibition of ice crystal growth, thermostatic activity and recrystallization inhibition activity have not been clearly and systematically resolved.
"Research Progress on the Theoretical Mechanism of Interaction between Antifreeze Protein and Ice-Water Interface Layer" reviews relevant research at home and abroad, and reveals the characteristics of AFPs by regulating the structure of the ice-water interface layer by regulating the binding or interaction driving force of the adsorption-inhibition model, dipole-dipole model, crystal occupancy-lattice matching model, rigid body energy model, clathrate anchoring model, affinity interaction coupling agglomeration model, etc. The main modes of action and mechanism of AFPs in generating thermal stagnation activity and recrystallization inhibition activity are analyzed, which provides new ideas for the research and industrial application of antifreeze protein.
Create an integrated ecology of production, education, research and application, and promote the development of scientific and technological innovation. In fact, this is not the first time that the People's Republic of China Peptide Group has cooperated with the scientific research teams of Fuzhou University and Shanghai Jiao Tong University. Previously, the People's Republic of China Peptide Group reached cooperation with the scientific research teams of Fuzhou University and Shanghai Jiao Tong University to jointly innovate the technical invention " Key Technology for Efficient Preparation of Antifreeze Polypeptides from Natural Protein Sources and Industrial Application " , which was successfully awarded the first prize of the 2019 Fujian Provincial Science and Technology Progress Award" for its technical invention. The innovative achievements of the scientific research teams of The People's Republic of China Peptide Group and Fuzhou University and Shanghai Jiao Tong University, "Industrialized Green Preparation and Demonstration of Natural Antifreeze Polypeptides", won the first prize of the 2020 China Petroleum and Chemical Industry Federation Science and Technology Progress Award.
Not only that, the People's Republic of China Peptide Group actively deepens the integrated development of production, education and research, and establishes a dual-track innovation mechanism of "independent innovation + collaborative innovation": introduce outstanding talents from colleges and universities to establish independent research and development teams, unite a number of universities and scientific research institutions to create an innovation system of "one institute and two stations" (functional peptide joint research institute, academician workstation, professor workstation), hire Professor Luo Yongkang of China Agricultural University as the chief consultant of national peptide product research and development, deepen industry-university-research cooperation, and innovate a number of patented technologies. Up to now, the People's Republic of China Peptide Group has successfully applied for nearly 100 patents.
Open innovation and cooperation, science and technology, the future. For the published research papers, Mr. Zhang Heng, Chairman of the Board of Directors of the People's Republic of China Peptide Group, said: "These studies have laid a theoretical foundation for the subsequent development of national peptides, and in the future, we will continue to strengthen the integration of industry, education and research innovation cooperation, actively promote the transformation of science and technology into production, further improve the peptide health industry ecology, empower the high-quality development of peptides, and wholeheartedly seek well-being for public health!" ”