In recent years, the aging trend of the national population has become more significant, and the prevalence of aortic stenosis has increased correspondingly rapidly.
In a study of 5,201 patients with cardiovascular disease over the age of 65, 26% had aortic degeneration and 2% had a diagnosis of aortic stenosis. With age, the proportion of people with aortic valve degeneration also shows a clear upward trend.
Is there a way to reduce the incidence of aortic stenosis? Perhaps keeping moving is a piece of advice to take.
On July 2, Professor Wu Yongjian's team from Fuwai Hospital of the Chinese Academy of Medical Sciences published a study based on the United Kingdom biobank in the European Heart Journal, and the results showed that moderate-to-high-intensity physical activity (MVPA) can help prevent the occurrence of aortic stenosis and reduce the intervention and death associated with aortic stenosis, but has no obvious preventive effect on aortic regurgitation and mitral regurgitation.
Study design
The researchers included the MVPA data of 87,248 people wearing accelerometers in the United Kingdom biological database in 2013~2015, and the MVPA data of 361681 people based on questionnaires in 2006~2010. The primary outcome is the diagnosis of new-onset degenerative valvular heart disease (VHD), including aortic stenosis (AS), aortic regurgitation (AR), and mitral regurgitation (MR). Secondary outcomes were VHD-related intervention or death.
Findings:
After a mean follow-up of 8.11 years, the MVPA cohort ended with 555 AS, 201 AR, and 655 MR.
- There is a dose-response relationship between the amount of MVPA and the risk of AS-related events.
The incidence of AS also steadily decreases with an increase in the amount of MVPA, and a corresponding decrease in the risk of AS-related intervention or death. The amount of MVPA stabilized after more than 300 min per week. In contrast, the association with the incidence of AR or MR is less pronounced.
In the questionnaire cohort, the researchers also observed a reduction in the risk of aortic stenosis (1.41 per 10,000-year decrease in the incidence of AS in the highest quartile of MVPA compared to the lowest quartile of MVPA volume; AS-related interventions or deaths were reduced by 0.38 per 10,000 person-years]. This beneficial association remained consistent in populations at high risk of AS, including those with hypertension, obesity, dyslipidemia, and chronic kidney disease.
Conclusions of the study
Higher MVPA amounts are associated with a lower risk of developing AS and AS-related interventions or death. The researchers believe that future studies will require a wider population, longer duration, and repetitive activity monitoring to further validate these findings.
However, it should be noted that the data of the China Geriatric Valvular Disease Registration Study (China-DVD) released in 2022 shows that the disease spectrum of elderly valvular heart disease in China is different from that of Western countries, aortic stenosis is the most common heart valve disease in Europe and United States, and mitral valve regurgitation is the most common in China.
Overall, we look forward to seeing the results of the study on the association between physical activity and other valve degenerative conditions such as mitral regurgitation.
This article is transferred from China Medical Tribune Today
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