"I'm young, why do I get gout?"
In the ward of the Rheumatology and Immunology Department of the Provincial Hospital Affiliated to Harbin Institute of Technology, 18-year-old Xiaoqiang was lying on the hospital bed, depressed.
I can't figure out that I am in the prime of life, but I am sick and painful, and I can't even get out of bed and walk.
I was even more annoyed and irritable, how could this disease find me?
Seeing that I am about to enter the university and enjoy my youthful campus life.
But a few days ago, I was admitted to the hospital because of the redness, swelling and pain in my knee, and even my travel plans with my friends were cancelled.
Desperate to get better, he quickly asked the doctor when he would be discharged from the hospital and when he would be able to get out of bed and walk.
But the doctor only said: whether this disease is good or not, the most important thing depends on yourself.
Myself? Xiaoqiang immediately said that he would definitely cooperate with the treatment.
The specific method does not sound difficult, but for Xiaoqiang, it has to work hard.
I didn't wronged him when I got this disease.
Xiaoqiang replaces water with carbonated drinks every day, and has been drinking since he was 16 years old.
Bad living habits have led to Xiaoqiang's weight of 200 pounds despite his height of 1.8 meters, accompanied by high blood lipids and high blood pressure.
High uric acid is slowly ruining the bodies of young people, and Xiaoqiang is not alone.
According to the latest chronic disease and risk factor monitoring data in mainland China, the prevalence of hyperuricemia among adult residents in mainland China is 14%, and that of gout is 0.86-2.20%.
With the increase in the pressure of life, many friends have fallen in love with "Little Sweet Water", and if they are in a bad mood, they will have a cup, which is simply delicious~
Some drinks even label themselves as "healthy", so that everyone can drink without burden.
But is that really the case? In fact, many of them are secretly destroying your body under the banner of health.
This kind of good thing of "rewarding" and "treating" oneself from time to time is quietly bringing a threat to one's physical health.
It is important to know that diet and lifestyle are closely related to the occurrence of gout and high uric acid.
Let's talk about these things about drinks in detail, unveil their mysterious "veil", and see which drinks are not suitable for everyone.
1. Sugary drinks
The first thing is the "little sweet water" we usually drink, whether it is milk tea, carbonated drinks or any bottled fruit tea drink, we have to drink less.
Needless to say, everyone knows that behind obesity is indispensable to the "fueling" of these things.
But what does this have to do with uric acid?
In fact, the increase in uric acid is not only related to a high-purine diet, but also related to the "three highs".
The four of them are not only "separate and their own kings", but "together" brings a huge threat to human health.
Zhou Zunhai, director of the Department of Endocrinology, Yangpu District Central Hospital, Tongji University, led his research team to study the correlation between visceral fat index and lipid accumulation index and blood uric acid in middle-aged and elderly people in the region.
The researchers included 868 participants and measured their physical indicators for data analysis.
The results of this trial suggest that obesity does affect elevated uric acid.
What's going on here?
This is because abnormalities in lipid metabolism in the human body can damage the blood vessels of the kidneys and cause them to harden, increasing resistance; The body excretes excess uric acid mainly through the kidneys.
It can be said that the kidneys are the "waste disposal station" of uric acid, and the blood vessels in it are the filtration machines in the site.
If the machine fails, then the efficiency of disposing of "waste" will naturally become slower.
There will also be more and more "excess uric acid" accumulated in the body.
Especially now there are many names for "little sweet water" that sound healthy.
For example, green plum green tea, rock sugar pear, etc., are actually very high in sugar.
These seemingly healthy-sounding little sweet waters not only make us fat, but also invisibly raise our uric acid.
Therefore, we must pay attention to when buying bottled drinks, and first hold back our excitement and take a look at the ingredient list.
Try to choose drinks with simple ingredient lists, low carbohydrate content, or sugar-free labels.
2. Freshly squeezed juice
Bottled drinks are easy to step on, so I will choose natural ones and drink freshly squeezed juices!
Well, not really.
Although the dietary guidelines for this disease recommend that everyone ensure a considerable intake of vegetables, fruits and dairy products, it also clearly states that foods with high fructose content should be restricted.
Among such foods, not only include the sugary drinks and fruit juice drinks mentioned above; There are even preserved fruit preserves and fructose syrup.
This is because fructose is able to induce metabolic abnormalities in the body, inducing an increase in uric acid levels by triggering abnormalities in insulin metabolism.
More than half of the fructose we eat is absorbed and metabolized by the liver, a process known as glycogenolysis and gluconeogenesis.
In this process, fructose is continuously broken down to provide energy to the body, and blood sugar rises. Some of them will become purines, which eventually produce uric acid.
The more fructose you eat, the more your liver breaks it down, and the higher your blood sugar is.
If the blood sugar is high, insulin will definitely not do it, and its job is to control the blood sugar level in the body.
But there is only so much insulin in our body, and if we don't have enough people, we will work overtime.
Friends who have worked overtime know that they can stand it for a while, and they can still guarantee a conscientious work state for a long time, and they just want to "touch the fish".
It's the same with insulin.
Long-term overtime, its "enthusiasm" to work decreases, and its ability to lower blood sugar decreases, resulting in insulin resistance.
The remaining fructose, which is not metabolized by the liver, is also metabolized by glucose transporters, which are mainly expressed in organs such as the kidneys.
If you eat too much fructose, it is equivalent to making the kidneys "work overtime".
Overexertion naturally leads to kidney damage, such as oxidative stress, inflammation, lipid accumulation, and impaired insulin signaling.
These injuries in turn lead to constriction of renal cortical blood vessels and damage to the tubulointerstitium, which ultimately affects the efficiency of the organ.
Naturally, it will not be able to excrete "excess waste" from the body.
However, a new problem has arisen.
Fruit also contains fructose, so why not let it eat less?
This is because the juiced fruit loses a lot of essence, and the nutritional value of the two is completely incomparable!
Many people have a misconception of contrast, and their habitual thinking makes them feel that a glass of fruit juice is equal to a fruit.
This is a very wrong way of comparison.
Some fruits have a low amount of juice, and it may even take seven or eight fruit juices to filter to make a glass of juice.
Under normal circumstances, a person cannot eat seven or eight apples in one sitting, but one can drink a glass of apple juice.
And this glass of juice contains seven or eight concentrated apples of sugar, which is properly overloaded.
Although fruit contains fructose, the content is lower than that of fruit juice.
In addition, our fruit players also have an "important equipment" - dietary fiber, which is a good thing.
When we talk about restricting sugar intake, we have always been restricting the intake of "free sugars".
This is a type of sugar that is added to food and is found in honey, syrups, fruit juices. This is also the main culprit of high sugar and fat.
And it is precisely because of the blessing of dietary fiber that the fructose in our fruit and vegetable contestants is not classified as free sugar by the WHO, but is called endogenous sugar.
The main difference between these two is that one is clothed and the other is not.
The endogenous sugar is wrapped in a layer of plant cell wall, so after entering the human body, our gastrointestinal tract first has to digest this layer of "clothing" and then digest the sugar inside.
Free sugars enter the human body "naked" and are naturally digested quickly, making it easier to affect our blood sugar levels in a short period of time.
Seeing this, don't step on the "pit" of freshly squeezed juice! In addition to sugary drinks and freshly squeezed fruit juices, alcohol can also cause an increase in uric acid levels in the body.
3. Drinks
Chinese Institute of Health Management of the General Hospital of the People's Liberation Army, in conjunction with the Science and Technology Research of the National Population and Family Planning Commission, conducted research on "the relationship between alcohol consumption and blood pressure, blood glucose, blood uric acid, and blood lipids".
In this study, 3911 healthy subjects were selected, and data were collected and analyzed through questionnaires, physical examinations and biochemical examinations.
The results showed that with the increase in alcohol consumption, the level of blood uric acid, as well as the rate of abnormal blood uric acid, showed an upward trend.
Alcohol is metabolized in the body primarily through the liver, and lactic acid accumulation can also occur in the process.
However, there is a competitive relationship between lactic acid and uric acid, and too much lactic acid will inhibit the excretion of uric acid, which in turn will increase the level of uric acid.
And ethanol itself also promotes the breakdown of purines.
In this way, the uric acid in the body was not discharged, and now there is a new one, and the uric acid in the body is naturally more and more.
For example, rice wine and beer themselves contain more purines, which is a source of purine increase in the body.
If you encounter these drinks again in your daily life, don't be greedy, and take care of your health!
Bibliography:
[1] Zhang Xuan'e, Gu Jiang, Zhang Xiaoyan, et al. Correlation between visceral fat index and lipid accumulation index and blood uric acid in middle-aged and elderly community population in Yangpu, Shanghai. Journal of Tongji University(Medical Science),2020,41(2):185-191.
［2］ZHANG M, ZHU X, WU J, et al. Prevalence of hyperuricemia among Chinese adults: findings from two nationally representative cross-sectional surveys in 2015-16 and 2018-19 I . Front Immunol, 2022,12: 791983.
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