The sixth issue of Environment & Health, a new journal co-published by the Research Center for Eco-Environmental Sciences of the Chinese Academy of Sciences and the American Chemical Society, was officially launched on June 21, 2024, containing 2 review articles and 5 research articles, covering a variety of topics.
Environment & Health is committed to revealing the relationship between environmental exposure and human health, exploring potential public health impacts, and building a high-level international academic exchange platform for sustainable development and a healthier world. The journal focuses on the impact of changing environmental hazards on human health, highlighting high-level original research of significance, as well as innovative ideas related to environmental and health policy. The journal will publish a variety of types of articles such as Research Article, Review, Policy Analysis, Perspective and Viewpoint. Manuscripts will undergo rigorous and rapid peer review.
REVIEW
Advancing Environmental Toxicology In Vitro: From Immortalized Cancer Cell Lines to 3D Models Derived from Stem Cells
In vitro model trends in environmental toxicology: from immortalized cancer cell lines to stem cell-derived 3D models
In this paper, more than a dozen cell lines commonly used in the field of environmental toxicology are introduced. It not only elaborates on the historical background of these cell lines, but also analyzes their unique characteristics and advantages in mechanism studies through case studies, aiming to facilitate researchers to select suitable cell lines for toxicology experiments. In addition, several promising in vitro models are discussed, including pluripotent stem cell lines, embryoid bodies, organoids, and organ-on-a-chips. The construction methods, characteristics and future improvement of these models are introduced in detail. This article provides an overview of the development of in vitro models in environmental toxicology, and compares commonly used models from multiple dimensions such as efficiency, accuracy, cost, and technical complexity. In addition, according to the needs of future developments in the field of environmental toxicology, the advantages and disadvantages of these in vitro models are prospected.
Hanyue Li, Nuoya Yin*, Renjun Yang, Francesco Faiola
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences
REVIEW
Thyroid Hormone Biomonitoring: A Review on Their Metabolism and Machine-Learning Based Analysis on Effects of Endocrine Disrupting Chemicals
Thyroid hormone biomonitoring: a review of the metabolism of thyroid hormones and machine learning-based analysis of the effects of endocrine disruptors on them
The team of Associate Professor Yao Yiming from the School of Environmental Science and Engineering of Nankai University reviewed the metabolic process of thyroid hormones and the distribution of thyroid hormones and metabolites in human tissues and organs. Combined with machine learning methods, the epidemiological survey data of the effects of endocrine disruptors on thyroid hormone levels were analyzed, and the results of the analysis were combined with current toxicological studies to illustrate the potential risk of thyroid dysfunction of endocrine disruptors from two perspectives.
Shijie Chen(陈师捷),Mengjie Yu(于梦婕),Yiming Yao(姚义鸣)*,Yongcheng Li(李永程),Ana He(贺阿 周子军),Liyang Pan(潘立阳),Nan Xiao(肖楠),Haining Luo(罗海宁),Hongwen Sun(孙红 文)
School of Environmental Science and Engineering, Nankai University
ARTICLE
Bisphenol AP Exposure-Induced Inflammatory Response in Zebrafish Embryos Revealed by Transcriptomic Analysis
Transcriptome analysis revealed that BPP exposure induced inflammatory response in zebrafish embryos
In this study, we evaluated the toxicity of BPAP exposure to early zebrafish development using a zebrafish model, and revealed the changes in gene expression and pathways and possible mechanisms in zebrafish after exposure through transcriptome sequencing analysis.
Qingjiang Ding (丁清江) and Hailin Wang (汪海林)*
Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences; Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences; University of Chinese Academy of Sciences
ARTICLE
High Magnetic Property and Toxicity of Particulate Matter Generated during Welding and Cutting Processes
Particulate matter emitted from welding and cutting is highly magnetic and highly toxic
The atmospheric health team of the Department of Environmental Science and Engineering at Fudan University reported that "particulate matter emitted from welding and cutting is highly magnetic and highly neurotoxic". After discovering that the fine particulate matter emitted from the steel production (steel industry) and the use of steel (brake pads, etc.) has strong magnetic characteristics, the research team further found that the fine particulate matter produced during the steel processing process (welding and cutting process) is more magnetic and toxic based on experimental research.
Wei Cui（崔伟）, Zizhen Ma（马子轸）, Yuanzheng Chen（陈源正）, Shuya Li（李淑雅）, Di Wu（吴菂）, Xiu Chen（陈秀）, Yuankai Shao（邵元凯）, Yuzhe Liu（刘昱喆）, Qing Li（李庆）*, Jianmin Chen（陈建民）
Department of Environmental Science and Engineering, Fudan University, School of Environmental and Municipal Engineering, Qingdao University of Science and Technology
ARTICLE
Chlorinated Polyfluoroalkyl Ether Sulfonic Acids (Cl-PFESAs) Are Associated with Eye Diseases in Humans and Eye Toxicity in Zebrafish
Polyfluoroalkyl ether sulfonates (Cl-PFESAs) have been associated with ocular disease in humans and ocular toxicity in zebrafish
A research team from Sun Yat-sen University reported that high levels of PFAS in the human serum, especially Cl-PFESA, are associated with an increase in eye diseases. In zebrafish experiments, Cl-PFESAs exposure induces zebrafish eye toxicity through oxidative damage and apoptosis. This study provides human clinical data and animal experimental data showing that Cl-PFESAs can increase the risk of eye diseases.
Lu-Yin Wu (吴路银)，Li-Xia Liang (梁丽霞)，Yang Zhou (周洋)，Zeeshan Mohammed, Zhengmin Min Qian, Stephen Edward McMillin, Maya Tabet, Chu Chu (楚楚)，Yuan-Yuan Fan (范园园)，Jia-Xin Zhou (周加欣)，Jing-Wen Huang (黄静雯)，Wei-Hong Tan (谭卫红)，Guang-Hui Dong (董光辉)*，Li-Zi Lin (林力孜)*
School of Public Health, Sun Yat-sen University; South China Institute of Environmental Sciences, Ministry of Ecology and Environment; Saint Louis University; St. Louis University of Health Sciences and Pharmacy; Reproductive Medicine Center, Guangdong Provincial People's Hospital; Center for Reproductive Medicine and Genetics, People's Hospital of Guangxi Zhuang Autonomous Region
ARTICLE
Active Molecular Network Discovery Links Lifestyle Variables to Breast Cancer in the Long Island Breast Cancer Study Project
Active molecular networks linking lifestyle and breast cancer in the Long Island Breast Cancer Study cohort
Based on metabolomic measurements of blood samples from breast cancer patients and normal humans, researchers from the Icahn School of Medicine at Mount Sinai discussed the small molecule regulation mechanism of lifestyle on breast cancer prevalence in the Long Island Breast Cancer Study Cohort Questionnaire, and found that the inflammatory effects of DiHODE and its metabolites may mediate the impact of different lifestyles on breast cancer. At the same time, this paper proposes a method for constructing active molecular networks based on "gatekeeper molecules", which focuses on the known and unknown metabolite networks that are correlated with metabolites and their regulatory mechanisms in the association with environmental exposure and disease.
Miao Yu*, Qian Li, Georgia Dolios, Peijun Tu, Susan Teitelbaum, Jia Chen, Lauren Petrick
Icahn School of Medicine at Mount Sinai, USA
ARTICLE
Tracking Source Variations of Inhalation Cancer Risks and Ozone Formation Potential in Hong Kong over Two Decades (2000–2020) Using Toxic Air Pollutant Monitoring Data
Toxic Air Pollutants (DAPs) monitoring data were used to track changes in the sources of inhalation cancer risk and ozone formation potential in Hong Kong over the past 20 years (2000-2020).
Prof. Jianzhen Yu and Prof. Qihan Liu from the Division of Environment and Sustainable Development at the Hong Kong University of Science and Technology (HKUST) used a positive matrix factorization (PMF) model to quantify the significant source changes in the risk of inhalation cancer (ICRs) and ozone formation potential (OFP) in Hong Kong, China from 2000 to 2020 based on toxic air pollutant (TAPs) monitoring data. The importance and necessity of TAP monitoring is demonstrated. It is expected that the establishment of a similar TAP monitoring network in the GBA will provide the monitoring data needed to help develop more effective air quality management policies.
Yi Ka Wong, Y.Y. Chan, Dasa Guo, Jian Zhen Yu*, Alexis K. H. Lau*
The Hong Kong University of Science and Technology