With the improvement of living standards and changes in dietary structure, high uric acid is increasing day by day, and has become the "fourth highest" that threatens health after hyperlipidemia, hypertension and hyperglycemia.
Many people think that high uric acid is due to eating too much "high-purine food", but in fact, this exogenous intake only accounts for 20% of the total uric acid, and endogenous metabolic disorders caused by lifestyle habits are the main cause.
There are 6 habits in life that will secretly help increase uric acid, which ones are they?
corpulent
Hyperuricemia is one of the common complications of obesity, and elevated uric acid can also promote liver fat deposition to a certain extent. Studies have shown that obesity is very closely related to hyperuricemia.
The higher the degree of obesity, the higher the prevalence of hyperuricemia. The higher the lipids, the higher the prevalence of hyperuricemia. Studies have found that 60%~80% of patients with hyperlipidemia are accompanied by hyperuricemia, and blood uric acid concentration is positively correlated with triglyceride level.
Why are obese people prone to high uric acid? The core reasons are twofold:
First, obese people have more free fatty acids in their bodies, which leads to increased triglyceride and uric acid synthesis. The acidic products produced by fat metabolism can inhibit the excretion of uric acid, which indirectly promotes the increase of blood uric acid.
Secondly, obesity is usually accompanied by disorders of glucose and lipid metabolism, insulin resistance, chronic low-grade inflammation throughout the body, and increased oxidative stress. Insulin resistance, on the other hand, can cause decreased blood flow to the kidneys, resulting in decreased uric acid excretion and increased blood uric acid levels.
Drinking
From 2012 to 2017, Peking Union Medical College Hospital conducted a national health survey, which found that 12.8% of people with hyperuricemia were caused by alcohol consumption.
Many people think that only beer causes high uric acid, but in fact, as long as it contains alcohol, it is easy to increase uric acid in the human body, why is this?
After alcohol enters the body, it is metabolized by the liver, and a large amount of water in the blood will be occupied during the metabolic process, so that the concentration of uric acid in the blood vessels will be greatly increased, and the blood urine value will become high. Therefore, after drinking a lot of alcohol, acute gout is often induced.
In addition, the metabolite of alcohol in the body is lactic acid, which causes the accumulation of lactic acid and ketone bodies in the body. The metabolic mechanism of lactic acid is similar to that of uric acid, which can competitively inhibit the excretion of uric acid, resulting in a high blood uric acid value in the body.
Sugar-sweetened beverages
The study found that drinking sugar-sweetened beverages increased the risk of hyperuricemia by 35%, and that the risk of gout increased by 85% with 2 or more servings of sugar-sweetened beverages per month.
Why are sugary drinks the "mastermind" behind hyperuricemia? The root cause is that sugar-sweetened drinks contain a lot of fructose.
On the one hand, fructose is different from other monosaccharides in that it is the only monosaccharide known to alter uric acid content, and its metabolism in the liver can promote the production of uric acid.
On the other hand, fructose can also induce metabolic abnormalities, stimulate the synthesis of long-chain fatty acids in the body, cause a decrease in insulin sensitivity, lead to insulin resistance in the body, and indirectly reduce the excretion of renal uric acid.
Lack of sleep
One in five sleep-deprived people suffers from hyperuricemia, with a prevalence of 19.8%, which is significantly higher than that of normal sleep and hypersomnia.
Reduced sleep time can also affect the neuroendocrine and autonomic nervous systems, which can raise blood pressure, blood sugar, and blood lipids. These factors can also lead to increased uric acid production, resulting in hyperuricemia.
If you don't get enough sleep, you might as well try to supplement lecithin, synthesize acetylcholine, the content of acetylcholine in the body increases, and there are more substances that provide information to the brain, and brain function can be enhanced. Regular supplementation of lecithin can allow the brain nerves to be nourished in a timely manner.
In addition, autonomic nerve dysfunction can lead to insomnia, headache, anxiety, etc., lecithin constitutes the human cell membrane and decomposes choline to nourish nerves, which is replenished every day, and the nervous system will be fully nourished and protected, promote the rehabilitation of nerve cell function, and prevent dysfunction.
Not athletic
Long-term adherence to appropriate aerobic exercise can speed up blood circulation, promote uric acid excretion, and maintain the dynamic balance of blood uric acid.
Patients with gout who are obese or diabetic can reduce visceral fat production and insulin resistance through exercise, which is beneficial for the prevention of gout attacks.
It is recommended to do aerobic exercise regularly, 4-5 times a week, 0.5-1 hour each time, mainly aerobic exercise, such as jogging, tai chi, swimming, cycling, etc.
Take your medication daily
Some common medications can also quietly raise uric acid, such as:
※ Aspirin
Aspirin has a dual effect on the metabolism of uric acid by the kidneys, high-dose aspirin (>3g/day) has the effect of promoting uric acid excretion, while low-dose aspirin (75~300mg/day) will significantly inhibit the renal tubular excretion of uric acid and increase blood uric acid.
※ Quinolone antibiotics
Clinical studies have found that norfloxacin, ciprofloxacin, ofloxacin and other quinolones have the risk of causing hyperuricemia, but the mechanism of action is not very clear at present, and may be related to the renal mechanical damage caused by these drugs and renal tubular secretion disorders.
※ Levodopa
Levodopa is metabolized in the body to homovanillic acid and mandelic acid. These two substances compete with uric acid for excretion pathways, reducing the amount of uric acid excreted and causing hyperuricemia.