laitimes

Diagnosis and treatment of anxiety, depression and insomnia

author:All Science Garden

Characteristics of anxiety disorder insomnia

  • Difficulty falling asleep and maintaining sleep
  • Sleep polymapping features of anxiety disorders
  • The sleep latency period is prolonged, and the sleep efficiency is reduced
  • Stage I and stage II sleep increases, and slow-wave sleep decreases
  • REM sleep ratio decreases. The incubation period is prolonged or normal
  • Increased limb movement during sleep

Depression is accompanied by symptoms of insomnia

Initial insomnia: It is difficulty in falling asleep, and it is not possible to fall asleep until the second half of the night, which is mostly caused by mental tension, anxiety, fear, etc.

Intermittent insomnia: It is not restful sleep, easy to wake up, often have nightmares, and middle-aged people have indigestion, which is often prone to this situation.

Endpoint insomnia: It is not difficult for Ti to fall asleep, but it does not last long, and she cannot fall back asleep after waking up in the middle of the night

The goal of clinical treatment of insomnia

Symptomatic relief: Shortens sleep latency, reduces the number of nocturnal awakenings, and prolongs overall sleep duration

Eliminate potential problems, remove triggers, and prevent the progression from transient or short-term insomnia to chronic insomnia

Maintain a normal sleep structure

Improve quality of life

Commonality of "Z-hypnotics".

Zaleplon, zolpidem, dexzopiclone

  • The subtype of the benzenediamidephypoxide receptor complex is more selective, selectively binding to the BZD receptor
  • No anxiolytic or muscle relaxant effects
  • Rapid onset of action: half-life 2-3 hours
  • Unlikely to affect sleep or prevent the brain from getting deep sleep
  • Maintain REM sleep
  • The risk of developing drug resistance and dependence was lower and was studied for up to 1 year
  • There are fewer withdrawal reactions and there is little potential for abuse
  • The risk of developing memory impairment is lower
Diagnosis and treatment of anxiety, depression and insomnia
Diagnosis and treatment of anxiety, depression and insomnia

Effect of antidepressants on sleep

  • Different types of antidepressants have different effects on sleep
  • SSRIs that activate 5-HT2 receptors, causing insomnia and alterations in sleep structure;
  • Blocking 5-HT2 receptors can improve sleep structure and increase sleep efficiency;
Diagnosis and treatment of anxiety, depression and insomnia

Source: 17 Dr. Han Zhengyu, Department of Neurology