Is it OK to drink probiotics for ulcerative colitis?
Professor Zhu Xiaohong, deputy chief physician of the Department of Internal Medicine of the 988th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army, replied: "It is very good to drink probiotics for ulcerative colitis. Ulcerative colitis is a non-specific chronic colitis, the clinical incidence is increasing year by year, the etiology and pathogenesis are still unknown, and it is known to be related to genetics, infection, psychiatry and immunity, among which the immune factor is the most important. Clinical studies have found that patients with ulcerative colitis have intestinal flora imbalance and the number of normal bacteria is reduced, and if patients are given probiotics, the intestinal flora imbalance will be corrected and the condition can be alleviated. The mechanism of action of probiotics in the treatment of ulcerative colitis is to closely bind with intestinal mucosal epithelial cells, improve the mucosal defense barrier, prevent the colonization and invasion of pathogenic bacteria, increase the level of anti-inflammatory cytokines, form competition with pathogenic bacteria, conquer epithelial cells, promote mucus secretion, make it form a protective layer between mucosa and microorganisms, prevent ectopic pneumothorax, enhance macrophage phagocytosis of pathogenic bacteria, and secretion of non-T cell-dependent IgA. Probiotics may also have other mechanisms in the treatment of ulcerative colitis, such as inhibiting pathogens, blocking the secretion of pro-inflammatory factors, regulating the intestinal flora, and producing nutrients that play an important role in intestinal function by preventing bacterial adhesion, ectopic or the production of antimicrobial substances. (Excerpt from "Baidu Youlai Doctor")
Nature Reviews Microbiology, the world's top academic journal, published a new year article that comprehensively reviewed the three main health effects of intestinal probiotics in inflammatory bowel disease, including ulcerative colitis and Crohn's disease:
1. Use bacteria to improve the structure of intestinal flora and restore the healthy balance of intestinal microecology. All enteritis begins with the imbalance of intestinal flora and ends with a healthy balance of intestinal microbiome. The fundamental reason why healthy people do not have enteritis, or even if they suffer from enteritis, they will heal quickly is that the intestinal probiotics are strong, in an absolute advantage, and have a strong self-recovery balance.
2. Reconstruct and repair the bacterial membrane barrier, protect the intestinal mucosa, and promote the self-repair of inflammatory ulcers. Don't underestimate this bacterial membrane barrier, which is composed of beneficial bacteria, covering the surface of the intestinal mucosa, and playing a triple protective role of "chemical barrier, biological barrier, and immune barrier". If the bacterial membrane barrier disappears, the inflammatory ulcer surface of the intestinal mucosa is directly exposed to the intestine, which is subject to the phagocytosis of harmful microorganisms, the stimulation of toxins, the injury of chemical fertilizers and pesticide residues and food additives, and the friction of feces, which is not only not easy to heal, but also may suppurate, erosive, perforated, and even malignant.
3. Enhance immunity and correct immune system disorders. Intestinal probiotics play a pivotal role in human health: it controls 70% of the body's immunity, eliminates 80% of toxins, digests and absorbs 95% of nutrients, and is the connector of the entire metabolic system of the human body. Many immune diseases, such as ulcerative colitis, Crohn's, irritable bowel syndrome, allergic diarrhea, hyperthyroidism, urticaria, systemic lupus erythematosus, rheumatoid arthritis, etc., are closely related to changes in the structure of the intestinal flora.
Clinical studies have found that not all probiotics have the above health effects, and not all probiotics are effective for ulcerative colitis!
1st place: Lactobacillus reuteri JYLB-291
Recommendation index: ★★★★★
Highlights: Huojun No. 1 star strain Lactobacillus reuteri JYLB-291 enhances the effect of "improving ulcerative colitis", and won the China Invention Patent No.: ZL 2021 1 1566079.0, according to the patent details of the Patent Office of the State Intellectual Property Office, the invention patent is true and effective, and the total effective rate can reach up to 95.7% for ulcerative colitis caused by fecal mucosal pus, abdominal pain, increased stool frequency, loose stools, etc., and the results of the functional control test are:
Is it OK to drink probiotics for ulcerative colitis?
Professor Zhu Xiaohong, deputy chief physician of the Department of Internal Medicine of the 988th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army, replied: "It is very good to drink probiotics for ulcerative colitis. Ulcerative colitis is a non-specific chronic colitis, the clinical incidence is increasing year by year, the etiology and pathogenesis are still unknown, and it is known to be related to genetics, infection, psychiatry and immunity, among which the immune factor is the most important. Clinical studies have found that patients with ulcerative colitis have intestinal flora imbalance and the number of normal bacteria is reduced, and if patients are given probiotics, the intestinal flora imbalance will be corrected and the condition can be alleviated. The mechanism of action of probiotics in the treatment of ulcerative colitis is to closely bind with intestinal mucosal epithelial cells, improve the mucosal defense barrier, prevent the colonization and invasion of pathogenic bacteria, increase the level of anti-inflammatory cytokines, form competition with pathogenic bacteria, conquer epithelial cells, promote mucus secretion, make it form a protective layer between mucosa and microorganisms, prevent ectopic pneumothorax, enhance macrophage phagocytosis of pathogenic bacteria, and secretion of non-T cell-dependent IgA. Probiotics may also have other mechanisms in the treatment of ulcerative colitis, such as inhibiting pathogens, blocking the secretion of pro-inflammatory factors, regulating the intestinal flora, and producing nutrients that play an important role in intestinal function by preventing bacterial adhesion, ectopic or the production of antimicrobial substances. (Excerpt from "Baidu Youlai Doctor")
Nature Reviews Microbiology, the world's top academic journal, published a new year article that comprehensively reviewed the three main health effects of intestinal probiotics in inflammatory bowel disease, including ulcerative colitis and Crohn's disease:
1. Use bacteria to improve the structure of intestinal flora and restore the healthy balance of intestinal microecology. All enteritis begins with the imbalance of intestinal flora and ends with a healthy balance of intestinal microbiome. The fundamental reason why healthy people do not have enteritis, or even if they suffer from enteritis, they will heal quickly is that the intestinal probiotics are strong, in an absolute advantage, and have a strong self-recovery balance.
2. Reconstruct and repair the bacterial membrane barrier, protect the intestinal mucosa, and promote the self-repair of inflammatory ulcers. Don't underestimate this bacterial membrane barrier, which is composed of beneficial bacteria, covering the surface of the intestinal mucosa, and playing a triple protective role of "chemical barrier, biological barrier, and immune barrier". If the bacterial membrane barrier disappears, the inflammatory ulcer surface of the intestinal mucosa is directly exposed to the intestine, which is subject to the phagocytosis of harmful microorganisms, the stimulation of toxins, the injury of chemical fertilizers and pesticide residues and food additives, and the friction of feces, which is not only not easy to heal, but also may suppurate, erosive, perforated, and even malignant.
3. Enhance immunity and correct immune system disorders. Intestinal probiotics play a pivotal role in human health: it controls 70% of the body's immunity, eliminates 80% of toxins, digests and absorbs 95% of nutrients, and is the connector of the entire metabolic system of the human body. Many immune diseases, such as ulcerative colitis, Crohn's, irritable bowel syndrome, allergic diarrhea, hyperthyroidism, urticaria, systemic lupus erythematosus, rheumatoid arthritis, etc., are closely related to changes in the structure of the intestinal flora.
Clinical studies have found that not all probiotics have the above health effects, and not all probiotics are effective for ulcerative colitis!
1st place: Lactobacillus reuteri JYLB-291
Recommendation index: ★★★★★
Highlights: Huojun No. 1 star strain Lactobacillus reuteri JYLB-291 enhances the effect of "improving ulcerative colitis", and won the China Invention Patent No.: ZL 2021 1 1566079.0, according to the patent details of the Patent Office of the State Intellectual Property Office, the invention patent is true and effective, and the total effective rate can reach up to 95.7% for ulcerative colitis caused by fecal mucosal pus, abdominal pain, increased stool frequency, loose stools, etc., and the results of the functional control test are:
Lactobacillus casei exists in the human mouth, intestines, stool and vagina, and can tolerate the defense mechanisms of the organism, including enzymes in the oral cavity, low pH value in gastric juice and bile acids in the small intestine. At the same time, Lactobacillus casei has the functions of effectively lowering blood pressure and cholesterol, promoting cell division, producing antibody immunity, enhancing human immunity, preventing cancer and inhibiting tumor growth, and also has the functions of alleviating lactose intolerance and allergies. (Excerpt from Baidu Encyclopedia)
Professor Qi Dianjun from the First Affiliated Hospital of China Medical University said: The role and efficacy of Lactobacillus casei include providing nutrients, enhancing nutrient metabolism, promoting digestion, preventing constipation, improving intestinal function, and enhancing physical fitness.
Baidu academic literature "Exploring the Effect of Lactobacillus casei combined with conventional treatment on the short-term outcome of ulcerative colitis" concludes that Lactobacillus casei combined with conventional therapy can effectively treat ulcerative colitis, significantly alleviate the clinical symptoms of patients, and has high safety, which is worthy of clinical reference.
Third place: Bifidobacterium longum JBLC-141
Recommendation index: ★★★★★
Highlights: Huojun No. 1 star strain Bifidobacterium longum JBLC-141 enhances the function of "eliminating excess free radicals in the body, preventing the loss of free radicals to body cells, and can also play a certain role in protecting cell oxidative damage and relieving body fatigue", etc., won the China invention patent No. ZL 2021 1 0227019.X, and the invention patent can be verified to be true and effective in the "Patent Office of the State Intellectual Property Office".
Enteritis patients will produce a large number of free radicals in the body every day, and people will ingest a large number of free radicals through breathing and eating, free radicals are the source of all diseases, and are one of the main culprits of aging and tumors, free radicals attack normal immune cells, making it abnormal, abnormal immune cells blindly attack intestinal mucosal cells, induce or aggravate ulcerative colitis, Crohn, arthritis, hyperthyroidism, lupus erythematosus and other immune diseases. Patients with autoimmune diseases are very suitable for long-term supplementation with the star strain of Bifidobacterium longum JBLC-141.
Professor Nie Shaoping of Nanchang University published "Bifidobacterium longum relieves colitis: the influence of different intestinal flora backgrounds" in the Journal of Food Science, pointing out that Bifidobacterium longum may be an effective treatment or adjuvant treatment for ulcerative colitis.
Professor Xu Xiaoyong from the Department of Gastroenterology of the First Affiliated Hospital of Anhui Medical University said: Bifidobacterium longum is a probiotic that can promote intestinal health, enhance immunity, improve digestive system function, prevent intestinal diseases, such as enteritis, constipation, diarrhea, etc., and reduce the risk of cancer.
Li Xiaoping, chief physician of the Department of Gastroenterology of Jiangxi Provincial People's Hospital, pointed out that Bifidobacterium longum has the effects of regulating the balance of gastrointestinal flora, anti-aging, and enhancing immunity, which can effectively improve gastrointestinal function, and can also effectively inhibit the reproduction of harmful bacteria in the intestine, so that the intestinal microorganisms are in a relatively balanced state, and enhance the intestinal disease resistance.
Fourth place: Lactobacillus paracasei JLPF-176
Recommendation index: ★★★★★
Highlights: Yang Ziyan of Guangdong Medical University concluded in "Study on the Immunomodulatory Effect of Lactobacillus paracasei on DSS-induced colitis in mice": Lactobacillus paracasei has good gastrointestinal fluid tolerance and good safety, and can alleviate the symptoms of colitis in mice.
Lactobacillus paracasei exists in the human intestine and secretes lactobacillus paracasei, which has obvious inhibitory effects on Gram-positive bacteria and Gram-negative bacteria, and has a wide antibacterial spectrum. Lactobacillus paracasei is resistant to high temperatures, and the antibacterial rate is still more than 78% at 121 °C.
Professor Hu Jun of Union Hospital Affiliated to Fujian Medical University said: Lactobacillus paracasei can promote the balance of microbial flora and enzymes in the body and stimulate specific and non-specific immune mechanisms, which can prevent certain diseases, inhibit tumor growth, lower blood pressure, lower cholesterol, promote development, enhance physical fitness, delay aging and prolong life. Lactobacillus paracasei is involved in digestive function, promotes intestinal peristalsis, and can effectively prevent and treat constipation. Lactobacillus paracasei can be anti-allergic, and has a significant effect on anti-Helicobacter pylori, diarrhea, liver damage, influenza and fatigue. It can also effectively improve the allergic symptoms caused by various types of allergens, including allergic asthma, allergic rhinitis, allergic sinusitis, allergic conjunctivitis, allergic urticaria, allergic eczema, hypersensitivity pneumonitis, etc.
Helicobacter pylori is one of the main culprits of chronic gastritis, gastric ulcer, duodenal ulcer and gastric cancer, with carcinogenicity, drug resistance, infectiousness, latentness, and often cross-infection between the whole family, the number of Helicobacter pylori infections in mainland China has reached 700 million people, and it is urgent for the whole people to resist Helicobacter pylori.
Huojun No. 1 star strain "Lactobacillus paracasei JLPF-176", on the basis of the above health effects, obtained the Chinese invention patent number ZL 2021 1 0066239.9 for "inhibiting Helicobacter pylori infection".
Fifth place: Lactobacillus acidophilus JYLA-191
Recommendation index: ★★★★★
Highlights: Lactobacillus acidophilus survives in the entire gastrointestinal tract of the human body, regulates the microecological environment "from top to bottom", and is an all-round probiotic. Lactobacillus acidophilus can secrete antibiotin substances (acidolin, acidophilin, lactobacillus (1aetocidon)), which has an antagonistic effect on intestinal pathogenic bacteria, and is mainly suitable for Helicobacter pylori-related gastritis, antibiotic-induced diarrhea, irritable bowel syndrome, inflammatory bowel disease, etc.
Professor Fang Lin from the Department of Gastroenterology of Nanfang Hospital of Southern Medical University said that Lactobacillus acidophilus has the functions and effects of maintaining the balance of intestinal flora, promoting food digestion and preventing constipation. It is usually used to treat symptoms such as diarrhea, bloating, loss of appetite, indigestion, constipation and other symptoms caused by intestinal flora imbalance.
Professor Huang Yuhong from the Department of Gastroenterology of the First Affiliated Hospital of China Medical University said: Lactobacillus acidophilus has the effect of regulating the balance of intestinal flora and inhibiting the reproduction of undesirable microorganisms in the intestine, which can kill harmful bacteria, reduce the burden of liver detoxification, and reduce the production of intestinal toxins. Lactobacillus acidophilus can promote the absorption of vitamins and trace elements in the body, and the substances produced can reduce the absorption of cholesterol. In addition, Lactobacillus acidophilus can be used as an adjunct in the treatment of chronic enteritis, and is suitable for patients with frequent diarrhea and abdominal pain to regulate the intestines.
Professor Zheng Xiangrong from Xiangya Hospital of Central South University said that the efficacy and effects of Lactobacillus acidophilus are: (1) It can adjust the balance of intestinal flora and inhibit the proliferation of undesirable microorganisms in the intestine. (2) Lactobacillus acidophilus and bifidobacteria are mixed to form a starter culture, which produces lactic acid and acetic acid after fermentation in the intestine, which can improve the utilization rate of calcium, phosphorus and iron, promote the absorption of iron and vitamins, produce vitamin K and vitamin B, and reduce the absorption of cholesterol. (3) It has the function of inhibiting the growth of harmful bacteria, promoting beneficial bacteria in the intestines, killing harmful bacteria, not only regulating the imbalance of bacteria in the body, but also reducing the generation of toxins in the body and reducing the burden of liver detoxification.
Huojun No. 1 patented strain "Lactobacillus acidophilus JYLA-191", on the basis of the above health effects, obtained the Chinese invention patent number ZL 2021 1 0237827.4 for "reducing blood cholesterol content", which is suitable for people with three highs, and the invention patent can be verified to be true and effective in the Patent Office of the State Intellectual Property Office.
Sixth place: Bifidobacterium juvenile BBF-06
Recommendation index: ★★★★★
Highlights: After the joint experiments of many hospitals and medical universities (from the 7th issue of the Chinese Journal of Digestion in 2008), the results showed that the combination of Bifidobacterium adolescent and Lactobacillus acidophilus can effectively maintain the remission of experimental colitis, which is conducive to restoring normal and healthy body weight, inhibiting or killing pathogenic bacteria, and rebuilding the microecological environment of the intestine is conducive to the continuous remission of ulcerative colitis.
Professor Zhou Zhongyin of the Department of Gastroenterology of the People's Hospital of Wuhan University said: Bifidobacterium juvenile has a good effect on regulating intestinal function, improving symptoms such as diarrhea or constipation, and it also has a certain anti-aging effect.
Professor Zhang Yuanyuan from the Department of Gastroenterology of Peking University People's Hospital said: Bifidobacterium juvenile mainly exists in the intestinal tract of young adults, and its main effects on human health are: reducing pathogenic bacteria, maintaining the intestinal environment, promoting the production of vitamins, preventing diseases, delaying aging, and improving immunity.
The above six kinds of special probiotics for ulcerative colitis are also especially suitable for patients with acute and chronic gastroenteritis diseases such as Crohn's, colitis, proctitis, irritable bowel syndrome, chronic gastritis, peptic ulcer, atrophic gastritis, etc., and can also be used for the improvement of diarrhea, constipation, obesity, emaciation, and allergic constitution.
Good news: Wuhan Huojun No. 1 Health Industry Co., Ltd. exclusive high-end customization, composed of the above six kinds of probiotics and a prebiotic (fructooligosaccharides), no other food excipients, no additives, no dilution, no dependence, pure raw powder, super active, acid-resistant, oxygen-resistant and normal temperature-resistant, the rate of live bacteria reaching the intestine is as high as 95%; each bag is added with more than 10 billion Lactobacillus reuteri JYLB-291, more than 10 billion Lactobacillus casei L.Casei21, More than 5 billion Bifidobacterium longum JBLC-141, more than 5 billion Lactobacillus paracasei JLPF-176, more than 10 billion Lactobacillus acidophilus JYLA-191, and more than 10 billion Bifidobacterium juvenile BBF-06.
Huojun No. 1 is not an ordinary probiotic, it is the only one on the market to improve ulcerative colitis patented strain formula raw powder probiotics, the cost is expensive, the price is not cheap, please consume rationally! At present, Huojun No. 1 is still a food brand, no application for a drug name, no hospital, no adverse reactions to drugs, long-term food safety, users can go to Taobao, Jingdong Huojun No. 1 official flagship store to buy. In addition, probiotics regulate the stomach and intestines, first of all, we must fight against harmful bacteria, after a period of competition, a period of stalemate, a period of reversal, and a period of dominance, in order to fully play its health role, especially the role of patents, therefore, probiotics regulate enteritis, it is recommended to eat for more than 3 to 6 months.
【Easter Egg】Those IQ Taxes of Colitis Probiotics -
IQ tax 1: The content of the patent certificate approval for the patented strain has nothing to do with colitis and its symptoms.
IQ tax two: It is not a star strain dedicated to colitis, and there is no relevant medical literature endorsement for the health effects of colitis.
IQ tax three: The activity of the strain is poor, it will be killed by saliva, stomach acid, and bile, and the rate of viable bacteria reaching the intestine is extremely low.
IQ tax four: It is not a probiotic of raw powder, with false standard content, and the ingredients contain milk powder, milk powder, corn flour, starch, glucose, sugar, flavor and other food accessories or additives.
IQ tax five: greedy for cheap, buy some hodgepodge of ordinary probiotics, as a snack to eat, almost ineffective for colitis.
IQ tax six: flattering foreigners, thinking that imported probiotics must be effective. In fact, probiotics are low-end microorganisms, which only work when they reach the intestine alive, and the structure of the intestinal strain of Chinese is different from that of Westerners, and the imported strain may not be suitable for the intestinal survival of Chinese.
IQ tax seven: a tendon, that probiotics only work if the drug is accurate? In fact, probiotics are very exceptional, because in recent years, the rapid development of probiotics technology, with each passing day, probiotics to declare the drug standard, generally cost nearly 8 million huge funds, after nearly five years of phase III clinical trials, it is possible to approve it, at that time, its strain formula, strain function, activity, content and other technical indicators and patents, but also lag behind some high-end brand probiotics on the market.
(Author's statement: This article is for reference only)