In the field of treatment of male dysfunction, sildenafil and other phosphodiesterase inhibitor drugs type 5 are currently the most widely used first-line drugs in clinical practice, and the varieties of such drugs that have been marketed include sildenafil, vardenafil, tadalafil, avanafil, etc., among these drugs with different names, sildenafil and tadalafil are currently the most widely used.
In some cases, when the patient visits, the doctor will recommend that the patient change sildenafil to tadalafil, which may lead to questions: they are all the same drugs, why do they have to be changed? What is the advantage of tadalafil compared with sildenafil? In today's popular science, I will talk to you about this topic.
What are the advantages of tadalafil over sildenafil?
As the first drug of type 5 phosphodiesterase inhibitor that has changed from a cardiovascular drug to an andrology treatment drug, its listing has brought a revolutionary change to the "sexual happiness" of countless middle-aged and elderly men in their later years, and has also achieved its original research company Pfizer's leading position among global pharmaceutical companies.
Compared with the first-generation drug sildenafil, the later marketed tadalafil is not just a drug obtained by mildly modifying the chemical structure of sildenafil, but a PDE5 inhibitor drug with a new chemical structure, and its main feature is a "long" Compared with the onset time of the drug in the body, the duration of sildenafil is about 8 hours, while the effect of tadalafil can last up to 36 hours, therefore, for some men with a relatively high frequency of activities, the use of tadalafil can play a role in taking it today and being effective the next day.
In terms of dietary effects, tadalafil is also less affected by diet, pharmacokinetic studies have shown that high-fat diet will affect the absorption rate of sildenafil, which is for on-demand time, when taking the drug after a high-fat diet, it is necessary to take the drug earlier to ensure the normal effect of the drug, and for tadalafil, its drug absorption is not affected by diet, and the normal time of taking it on demand can be taken in advance.
In these 3 cases, sildenafil can be considered to be adjusted to tadalafil
Of course, it is some situations that can give full play to the long-term effect of tadalafil, and there may be different tolerances to different drugs, so it may be difficult for many friends to understand, combined with the actual three situations that may need to consider changing drugs, and introduce them in detail.
1. Intolerance to sildenafil side effects
Drug-related adverse reactions may occur in both sildenafil and tadalafil, but sildenafil and tadalafil have different rates of adverse reactions and different tolerances in different populations.
In terms of the incidence of adverse reactions, headache, visual abnormalities, gastrointestinal discomfort, flushing, muscle pain, drug allergies and other adverse reactions are common adverse reactions that may occur with PDE5 inhibitors, but there are also certain differences in the intensity and probability of adverse reactions of different drugs. From a clinical point of view, sildenafil, especially in high-dose people, has a higher chance of developing visual abnormalities, while tadalafil is more likely to cause adverse effects of muscle pain.
If you have serious adverse reactions such as headache, visual abnormality, gastrointestinal discomfort and cannot tolerate sildenafil, you can consider switching to tadalafil to try it, and it is one of the solutions to solve the problem of intolerance of adverse drug reactions by switching to drugs. Of course, this does not mean that the adverse reaction rate of tadalafil is necessarily lower than that of sildenafil, and sometimes, there will be cases where you are intolerant to side effects of taking tadalafil and can be switched to sildenafil.
2. Take the medicine in advance as needed, causing psychological pressure and affecting the efficacy of the drug
For on-demand medication, sildenafil and tadalafil are recommended to be taken 0.5 hours before the couple's activities, some friends use this way of taking medicine, which often triggers the embarrassment of the individual or partner, thus forming a hint or influence psychologically, which affects the actual efficacy of the drug, and even leads to the drug taking effect, but due to the psychological effect, it affects the harmony of the couple.
For friends who have this kind of psychological pressure, as well as some friends who want to pay attention to the privacy of medication, it is a good way to separate the time of taking medication from the time of activity. Replacing sildenafil with tadalafil and giving full play to the long-term effect of tadalafil can ensure that the drug can still play an effective role at night after taking it during the day, greatly reducing the correlation between the drug and couple's activities, and is a good choice for reducing psychological pressure and ensuring the privacy of medication.
3. The effect of taking sildenafil is not good, and it needs to be adjusted to daily regular medication
There is also a situation that can be considered to change the dress, that is, if the effect of taking sildenafil on demand is not satisfactory and cannot effectively improve male function, you can consider taking regular medication to further improve the efficacy of the drug and improve the problem of male dysfunction.
Because taladafil is a long-acting drug, it can be used in the form of a low dose of 5mg daily regular medication, which on the one hand reduces the drug to improve the drug safety and patient tolerance, and on the other hand, it can also ensure that the patient's blood concentration remains stable and stable during the regular medication process. Not only can it effectively improve male function during couples' activities, but it can also help improve the health of vascular endothelial cells, and it is also good for improving natural erections at other times. This effect is very helpful in improving the patient's self-confidence, enhancing the effectiveness of drug treatment, and increasing the effectiveness of drug treatment.
Therefore, for regular medication, tadalafil has more advantages than sildenafil, and can also help to further improve the problem of male dysfunction.