"Cephalosporin with wine" has been on the hot search again in the past two days, a talk show actor said that he couldn't die after trying, and the expert stood up and criticized him for speaking irresponsibly, and I said that the expert was right.
The reason why cephalosporin leaves as soon as it is drunk with wine is because cephalosporins can inhibit the activity of acetaldehyde dehydrogenase in the liver, so that it cannot further metabolize acetaldehyde, the initial metabolite of alcohol, into acetic acid, resulting in acetaldehyde accumulation, making people dizzy and flushed all over the body drunkenness, and in severe cases, it will cause hypotension and even shock.
This reaction has a special name called "disulfiram-like reaction", and in addition to cephalosporins, metronidazole, which is often eaten with toothaches, can also cause this reaction. In fact, alcohol itself will affect the activity of liver enzymes, and liver enzymes affect drug metabolism, so no matter what kind of medicine it is, it is best not to pair it with alcohol.
Some people are bitter and may use a variety of drinks to take medicine, although these conditions are not as deadly as cephalosporin with wine, but they will also bring some health risks-
For example, many families will buy grapefruit, also known as grapefruit, which tastes sweet and sour, and can also squeeze juice. However, when this juice is paired with nifedipine, the concentration in the blood will increase due to the presence of furan (fū nán) coumarin in grapefruit, which inhibits the CYP3A4 enzyme in the liver, and nifedipine is metabolized by this enzyme.
There are quite a few drugs metabolized by the CYP3A4 enzyme, such as the common anticoagulant warfarin, and increased concentrations may cause intracerebral hemorrhage. For example, common antibiotics such as erythromycin and clarithromycin, or statins, may be more effective when the drug concentration increases, but the excessive accumulation of drugs also increases the risk of adverse reactions.
In addition to nifedipine, dipine calcium antagonists and antihypertensive drugs will be affected by grapefruit juice, and drug experts naturally know the pharmacology well. Source: Comic "Detective Conan"
Although C supplementation is good, a large amount of citric acid in orange juice can promote the absorption of aluminum, and aluminum is commonly used to treat gastric ulcers or some other stomach diseases.
Some people's C in the morning is coffee, caffeine in addition to affecting liver enzymes, itself can also stimulate the central nervous system, and many cold medicines are originally added with caffeine to help relieve fever and analgesia, and a cup of coffee is naturally more exciting. Caffeine can also reduce the absorption of Alpha by more than half.
Don't even think about any style of coffee
Tea also contains caffeine, which can also affect drug metabolism. It should be pointed out that although tea and tea extracts are not the same, there are studies that show that green tea extracts can reduce the blood concentration of lol antihypertensive drugs and warfarin, and tea is rich in organic matter, which will also combine iron and affect absorption.
Drinking tea is healthy, and drinking tea when taking medicine is not healthy
In the evening, we already know that we can't take medicine any later A (lcohal), so let's drink milk to maintain our health, and then we will take the medicine. However, dairy products are rich in calcium, which can form precipitates with floxacin antibiotics, which affects absorption. In fact, divalent cations such as zinc and magnesium will affect their absorption, considering that many vitamin supplements add these trace elements, it is best to eat them separately.
The reason why I didn't use this emoji at the beginning is that it's best not to drink milk either
Cheese made from cow's milk contains high amounts of tyramine, which are converted into monoamine neurotransmitters in the body. Usually monoamine oxidase can metabolize these substances, but some psychotropic drugs, or anti-tuberculosis drugs, can inhibit monoamine oxidase, and then eat cheese, there will be a series of reactions such as flushing, rapid heartbeat, and increased blood pressure, which is called "tyramine reaction". Although rare, this reaction is the same as "cephalosporin with wine", which is still more dangerous.
Don't ...... cheese pizza
Maybe you think that there is thunder everywhere, or you should drink something without color, such as soda. However, many drugs are sensitive to changes in the physical environment due to the manufacturing process. The more common are enteric-coated tablets, which are made because many drugs can be broken down in gastric juice and become ineffective, or have an irritating effect on the gastric mucosa, such as painkillers such as aspirin or indomethacin.
It's okay to drink soda on a regular basis
The surface of enteric-coated tablets has a layer of coating that is not easily soluble in acid, which can fight against stomach acid and allow the drug to dissolve in the alkaline environment of intestinal fluid. The soda contains sodium bicarbonate, which is weakly alkaline, which is likely to dissolve the coating in the esophagus in advance, and will reduce the acidity of gastric juice, thereby affecting the effect of the drug, and aspirin itself is also irritating to the stomach.
Of course, most of the above situations generally can't die, mainly because they affect the efficacy of the drug, at most, they are just uncomfortable, or they are sick and old. In order to spend less money and suffer less sin, it is better to drink warm water and take medicine.
Written by | Xiao Xu
Part of the picture | Picture worm creativity
WeChat edit | Zhao Zhiyu