With the improvement of people's living standards, the dietary structure has also changed relatively, especially some unhealthy lifestyles have gradually emerged. Since the 80s of the 20th century, the incidence of hyperuricemia and gout has risen sharply and remained high, gradually becoming a common and frequent disease that seriously threatens people's health. At present, there are more than 80 million gout patients in mainland China, making it the second largest metabolic disease in mainland China after diabetes.
It is worth noting that hyperuricemia and gout are often combined with hypertension, diabetes, hyperlipidemia, obesity, and various cardiovascular and cerebrovascular diseases. If gout is not treated properly, it can have recurrent attacks, which are likely to lead to tissue destruction, bone erosion, joint pain and stiffness, causing great pain to the body and affecting quality of life. So, what is gout?
01
What is Gout?
Gout is a clinical syndrome caused by abnormal purine metabolism in the body, increased serum uric acid (SUA) concentration, and chronic deposition of monosodium urate (MSU) crystals in articular capsule, bursa, cartilage, bone and other tissues due to metabolic and genetic factors. Gouty arthritis (GA), the first clinical manifestation of gout, is a common and treatable crystal inflammatory arthropathy that occurs in the first metatarsophalangeal joint but can also occur in other larger joints, usually acute and episodic, but can also progressively to chronic, and is more common in men [1].
Normal blood uric acid concentration: 178-416 μmol/L for men and 148.5-356 μmol/L for women. There is some difference in blood uric acid levels between normal adults and men, but the difference between blood uric acid levels and that of men disappears when women reach menopause.
02
What are Purines?
Except for patients with more severe gout, most doctors will recommend eating less foods that are high in purines. Purines are organic compounds that are divided into endogenous and exogenous. Endogenous purines are metabolites produced by cell breakdown and account for about 80% of total purines in the body, while exogenous purines are ingested from food and account for about 20% of total purines in the body. Purines go through a series of metabolic changes in the body to produce a substance called uric acid. Normally, most uric acid is excreted in urine through the kidneys, and a small amount is excreted in the stool through the intestines [2].
03
Formation of gout
Why do you get gout when uric acid is high? Generally, the daily production and excretion of uric acid are roughly equal, when the body produces too much uric acid or excretes too little, uric acid will accumulate in the body and be transported to joints and tissues with the blood. In the long run, uric acid will be deposited to form needle-like crystals, and immune cells in the body will accumulate around these crystals to produce an immune response, forming local inflammation, and gout will slowly accumulate.
Therefore, many people with gout avoid using crustacean seafood such as animal offal, shellfish, lobster, etc., as well as thick broths and gravies. In addition to eating less foods high in purines, there are some other alcoholic beverages and foods in daily life that will affect the excretion of uric acid.
Alcohol ✘
The ethanol in alcohol is metabolized in the human body, and the metabolites in it inhibit the excretion of uric acid from the body.
Juices, soft drinks ✘
Fruit juices, soft drinks, etc. contain a large amount of fructose, sucrose, fructose syrup, etc., and a large amount of fructose intake may accelerate the metabolism of purines, increase the content of uric acid in the body, thereby inducing gout attacks.
04
Characteristics of small molecule peptides
Small molecule active peptide is a cell nutrient, which can activate cell activity, inhibit cell variation, supplement cell total nutrition, repair damaged cells, and promote cell growth. It can also improve cell metabolism and prevent cell degeneration.
The small molecule active peptide can effectively scavenge the oxygen free radicals generated in the inflammatory reaction, protect the adjacent normal tissues, protect the cells from damage, and maintain the normal viscosity of the synovial fluid in the joint cavity. It can also activate the viability of diseased cells and effectively enhance the body's immunity [3].
In the past, gout was called "court disease" because the uric acid produced by the metabolism of cells in the body was not excreted in time when the nobles were eating and drinking, which caused gout. Tell your friends who suffer from gout that gout cannot be controlled only by diet, and standardized drug treatment is required under the guidance of a doctor.
Bibliography:
[1] Chen Shaohua, Zhao Xiao, Xu Hao, Wang Yongjun, Liang Qianqian.Research progress of traditional Chinese and Western medicine for gout[J].World Science and Technology (Modernization of Traditional Chinese Medicine).2021(4):1220-1227.
China Food Industry.2022(6):94-94.
[3] Zhang Li, "Healthy Peptides", China Science and Technology Press: 2021.1.
Platform Statement
Foodborne peptide is not a drug, peptide is a highly active, highly nutritious cell food, patients with diseases should not stop taking the drug without permission when eating peptides, follow the doctor's instructions, and regularly go to the hospital for regular reexamination and formal treatment. We are committed to protecting copyright, the content and pictures of the article are from the Internet, and the real source cannot be verified, for reference only. The content described in this article has nothing to do with individuals and any organization, if it involves infringement, please contact us directly to delete.