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Taking two or more drugs at the same time may cause reduced efficacy or side effects due to the interaction between them, and the direct effect of common cephalosporin antibacterial drugs and alcohol-containing drugs can cause acetaldehyde poisoning. Many medications should not be taken at the same time.
1. Cephalosporins: react with a variety of commonly used drugs
Cefsulfone, ceftriaxone, cefazolin, cefradine, cephalexin, cefaclor, etc., combined with alcohol-containing drugs such as Leixiang Zhengqi water, compound licorice oral solution, ten drops of water, hydrocortisone injection, etc., can cause facial flushing, headache, abdominal pain, sweating, palpitations, dyspnea and other symptoms, which is called disulfiram-like reaction.
Mechanism of occurrence: After alcohol enters the body, it is first oxidized to "acetaldehyde" by the action of "alcohol dehydrogenase", and then oxidized to "acetic acid" by the action of "acetaldehyde dehydrogenase", and acetic acid is further metabolized into carbon dioxide and water and excreted from the body.
After drinking the Raixiang Zhengqi water containing alcohol and then taking cephalosporins, because the cephalosporin antibacterial drugs can inhibit the activity of acetaldehyde dehydrogenase, so that acetaldehyde can not be further oxidized and metabolized after production, resulting in acetaldehyde aggregation in the body and disulfiram-like reaction. The reaction usually resolves spontaneously without special treatment, and symptoms lessen or disappear when alcohol is stopped. However, some individuals are sensitive and have severe disulfiram-like reactions, in which case appropriate treatment is required, such as oxygen, blood pressure maintenance, antishock, and symptomatic supportive care.
Patients and family members are reminded to refrain from drinking alcohol, including drugs and beverages containing alcohol, while taking cephalosporins and for 7 days after stopping the drug.
Second, the efficacy of erythromycin and vitamin C will be reduced
In life, erythromycin, which has anti-inflammatory and antibacterial effects, is also a standing medicine in the small medicine cabinet of citizens' homes, and it will also come in handy when some symptoms appear. However, doctors suggest that erythromycin and vitamin C should not be used together, because erythromycin has a significantly reduced effect in an acidic environment, which will reduce the efficacy, and vitamin C is a more acidic drug.
3. Dexamethasone + hypoglycemic drugs will increase blood sugar
Dexamethasone is a long-acting glucocorticoid commonly used in clinical practice, which has pharmacological effects such as anti-inflammatory, anti-allergic, anti-toxic, immunosuppressive and anti-shock, and is widely used in various departments in clinical practice.
Dexamethasone taken in large quantities for a long time will lead to central obesity in the body, and it is also easy to increase blood sugar and blood pressure, and when taken together with hypoglycemic drugs, it will weaken the effect of oral hypoglycemic drugs or insulin, affecting the patient's blood sugar level. Therefore, diabetic patients should monitor their blood glucose levels and adjust their medications and diet in time when using dexamethasone. If there is any abnormality, report it to the doctor immediately and adjust the treatment in time.
4. Antimicrobial drugs, live bacterial preparations, and iron drugs
Antimicrobial drugs are taken together with live bacterial preparations such as Bifidobacterium Triple Viable Bacteria Powder (Pefikang) to make the probiotics in Pefican ineffective. If you need to take the same dose, it is recommended to wait at least 2 hours. In addition, the combination of tetracyclines (tetracycline, doxycycline, etc.) and fluoroquinolones (ofloxacin, norfloxacin, etc.) in antibacterial drugs such as ferrous sulfate, ferrous fuma, ferrous gluconate, etc., will cause a comprehensive reaction between iron ions and antibacterial drugs, resulting in the failure of antibacterial therapy and blood tonic therapy.
5. Reserpine and dysentery
Diarrhoea is a monoamine oxidase inhibitor, when combined with the antihypertensive drug reserpine, the antihypertensive effect of reserpine will be rapidly weakened, and even reversed to make blood pressure higher than before treatment.
6. Gastrointestinal motility drugs and gastrointestinal anticancer drugs
Gastrointestinal motility drugs such as metoclopramide, domperidone (morphin), etc., are combined with antispasmodic drugs 654-2 (hyoscyamine), probenzine, etc., the former strengthens the contraction of the antrum and promotes the emptying of gastric contents: while the latter slows down gastrointestinal peristalsis, inhibits the emptying of the gastrointestinal tract, and pharmacologically antagonizes, thereby reducing the efficacy.
7. Aspirin and indomethacin
Although both are antipyretic, analgesic and anti-rheumatic drugs, the combination of them not only cannot enhance the efficacy, but is easy to aggravate the side effects on the gastrointestinal tract, so that the chance of gastric bleeding and perforation is significantly increased.
8. Tolbutamide (D860) and dihydrogramthia
Dihydrogramithiazine can inhibit the release of insulin from pancreatic islets, so that the level of insulin in the blood decreases and the blood sugar rises, which is the opposite of the hypoglycemic effect of tolbutamide, so it cannot be combined.
9. Calcium-containing traditional Chinese medicine and aminoglycoside antibiotics
Hyperbiotics such as gentamicin, tobramycin, and netimicin can bind to calcium ions, and if combined with calcium-containing traditional Chinese medicines, they will increase the neurotoxicity of aminoglycosides. Calcium-containing traditional Chinese medicines include keel, oysters, conch pins, antlers, wolfberries, etc.
10. Traditional Chinese medicine and enzyme preparations containing tannins
Traditional Chinese medicines containing a large amount of tannins, such as knotweed, cinnamon, nepeta, etc., cannot be combined with enzyme preparations such as pepsin, pancreatic enzyme, amylase, etc. Otherwise, it will become an insoluble precipitate and fail.
Therefore, it is best to take the medication under the guidance of a doctor, because the doctor will fully consider the patient's age, gender, pathology, physiology and drug influencing factors. In addition, if you bought an over-the-counter drug at a pharmacy and you can't consult your doctor, it's best to read the instructions carefully before taking it. After taking the medicine, once you feel unwell, you should seek medical attention in time.