After Mr. Feng and Ms. Zhou got married in 2013, they longed for a happy life for a family of three, but it backfired. After 3 years of pregnancy, they traveled to various hospitals, exhausted all kinds of remedies, and finally got pregnant in 2016.
Looking at the results on the test sheet, Ms. Zhou burst into tears with excitement, and her mind looped the words that the doctor had just said in the consultation room: "Congratulations, you are pregnant."
However, the joy of sharing the heartbeat with another life did not take long to feel it, and when the ultrasound was reviewed more than 2 months ago, the doctor told Ms. Zhou that the embryo was stopped.
After a three-month rest, the Fengs embarked on the road of seeking children again, this time for another three years. In 2019, Ms. Zhou was pregnant with a baby again, because of the experience of the last fetal arrest, this time every time the pregnancy follow-up, Ms. Zhou waited for the result with a nervous mood, sadly, this time the embryo stopped after more than 2 months of pregnancy.
In 2020, Ms. Zhou was pregnant with a baby again, but she still could not escape the curse of pregnancy for more than 2 months of pregnancy.
The repeated miscarriages have brought a huge psychological burden to the Fengs, and they have been asking the doctor why? We are so young, why do embryos stop breeding?
On the advice of the doctor, they underwent an embryo chromosome test after this evacuation. A month later, the results of the embryonic chromosomes were obtained: trisomy 16.
After getting the result, the Feng couple was instantly dumbfounded, the chromosomes of the couple are normal, why are the baby's chromosomes abnormal? What to do? How can I avoid getting pregnant with a baby with chromosomal abnormalities and stop recurrent miscarriages?
Later, they heard that the third generation of IVF could screen babies for chromosomes and avoid recurrent miscarriages caused by their chromosomal abnormalities. Through Ms. Zhou's classmates' introduction, they found Director Wen. After learning more about the Feng's condition, Director Wen believed that the Fengs met the conditions for the third generation of IVF.
In 2021, the Fengs embarked on the road of seeking children again, this time with stimulation obtaining 20 eggs, 19 normal fertilization, 8 high-quality blastocysts that could be biopsied, and the results were that 5 embryos were chromosomally normal and could be transferred, and the other 3 were chromosomally abnormal.
Finally, I waited for the news that the embryo could be transferred, but because of the previous multiple abortions to clear the uterus, the repeated ultrasound during the stimulation showed that Ms. Zhou's endometrium was relatively thin and there may be intrauterine adhesions. So Ms. Zhou underwent another hysteroscopy.
In April 2022, Ms. Zhou underwent a frozen embryo transfer procedure to transfer a blastocyst. The Feng couple finally ushered in the good news: the pregnancy test was positive, the first B ultrasound, the second B ultrasound fetal cardiofetal bud were normal, and 12 weeks of NT, 16 weeks of amniocentesis, 23 weeks of grade III color ultrasound all suggested that the baby was normal, and then the baby fell to the ground, the Feng couple finally cleared the clouds and saw the blue sky, relieved.
Preimplantation Genetic Testing (PGT), also known as the third generation of "IVF" technology, refers to the detection of single gene mutations, chromosome numbers or structural abnormalities before the sperm egg combines in vitro to form a fertilized egg to develop into an embryo, which can detect genetically abnormal embryos and select normal embryos to implant into the mother's uterus, thereby improving the clinical pregnancy rate and reducing the miscarriage rate. Prevent the birth of fetuses with single gene diseases and chromosomal abnormalities, and achieve the purpose of eugenics and fertility.
PGT-A: Preimplantation genetic testing technique for aneuploidy testing of embryonic chromosomes, suitable for couples with recurrent miscarriages, repeated implant failures, and infertile women over 38 years of age.
PGT-M: Preimplantation genetic testing technology for the detection of single-gene genetic diseases, suitable for couples with single-gene genetic diseases such as thalassemia, deafness, hemophilia, pseudohypertrophic progressive muscular dystrophy, spinal muscular atrophy, etc.
PGT-SR: Preimplantation genetic testing technique for the detection of chromosomal structural abnormalities. Suitable for couples with one or both chromosomal abnormalities or structural abnormalities (balanced translocations, Roche translocations, pathogenic microdeletions or microduplications, etc.).