I don't know if you have heard of the drug Betarak, and those who have elderly people in the family may not be unfamiliar with this drug. It is a medicine for the treatment of hypertension, angina, myocardial infarction and other diseases. Uncle Wang is a patient with high blood pressure for many years, and some time ago he was changed to a double tarok.
But he always couldn't remember whether to eat before or after meals, and he was very skeptical about the safety of the drug, always afraid that he would have any side effects. So what kind of medicine is Betarak? What are the precautions when taking medication? Let's take a look!
First, do you understand Bethalok
Betalac is also called metolol, and the drug we usually see generally has two dosage forms. One is the type of effervescent tablets, which is 25 mg a tablet, which is also more common. There is also a type of extended-release tablet, usually 47.4 mg per tablet.
Betalek is actually a beta1 blocker in β receptor blockers, and its blocking principle is described in detail by taking the vascular system as an example. It blocks the beta1 receptors of the heart, inhibits the activity of the heart, manifested by a slowing of the heart rate, a weakening of myocardial contraction, a decrease in cardiac output, and a decrease in myocardial oxygen consumption.
Therefore it is very useful for the treatment of angina. We know that the pathological mechanism of angina is the ischemia and hypoxia of the myocardium, which leads to the accumulation of local metabolites, such as lactic acid, adenosine, etc., which stimulates the angina caused by the ends of the pain god.
The application of β receptor blockers will reduce the oxygen consumption of the myocardium, thereby alleviating the symptoms of angina. Knowing its pharmacological mechanism, do you know what the specific effects of Betalek have?
Second, the role of Betalek
Betalek has a relieving effect on many conditions, such as high blood pressure and angina. Let's explain them one by one!
1. Treatment of blood pressure
Its antihypertensive mechanism is mainly divided into these aspects. The first is to block the β1 receptor in the heart, thereby reducing the amount of blood in the heart, and when the amount of blood in the heart decreases, our systolic blood pressure will also decrease.
The second is to block the beta1 receptors of the paraglomerular organs and reduce the secretion of renin. Renin can convert our angiotensinogen into angiotensin 1, and angiotensin 1 can be converted into angiotensin 2, which has a strong constrictive effect on blood vessels, thereby playing an elevated role in blood pressure.
At the same time, it can also block the peripheral β receptors of the epinephrine nerve endings, which can inhibit the regulation of positive feedback, thereby reducing the release of epinephrine. When β receptors are blocked, positive feedback is suppressed, reducing norepinephrine release and ultimately lowering blood pressure.
2. Angina pectoris
The root cause of angina is due to hardening in the center of the coronary arteries of our heart, which leads to stenosis. Under normal circumstances, the blood supply of narrow blood vessels can also meet the needs of the human body.
But once you run or carry something upstairs, the amount of blood your heart needs increases. However, the narrow blood vessels do not provide enough blood volume, which will produce painful symptoms, and some patients will also show a suffocated heart or a strong sense of obstruction in the throat.
When angina occurs, the sympathetic excitability of angina is enhanced, which excites the β receptors of the heart, thereby increasing the load on the heart. Betalek, on the other hand, reduces our myocardial oxygen consumption and inhibits the activity of the heart, thus achieving a therapeutic effect.
At the same time, Betalek can reduce the production of free fatty acids and increase the use of glucose by ischemic tissues. This is used to maintain the supply of myocardial energy, thereby improving myocardial metabolism.
3. Precautions
Although the treatment effect of this type of drug is good, it needs to be "careful". In particular, these two points must be paid attention to. The first thing is to monitor your heart rate, because the biggest side effect of this medicine is that it will slow down the beating of the heart.
If the heart rate is less than fifty times in the meditation situation, then symptoms such as dizziness and fatigue may even occur. At this time, be sure to go to the hospital to see a doctor, who may adjust your medication.
The second is that this type of drug must not be stopped suddenly, especially when you take a very large amount. Because sudden discontinuation of the drug will cause you to have a reflex heart rate increase, and even increase the risk of myocardial infarction or angina.
For the question of whether to eat before or after a meal, you can take a look at the suggestions below. Metoprolol is a fat-soluble drug, which means that it only has a higher solubility and a faster decomposition time in lipid substances.
Therefore, metoprol tartrate tablets should be taken before meals. Metoprolol succinate extended-release tablets can be eaten before and after meals due to the use of microcapsulation technology to achieve long-term effect. Because the presence of food does not affect its bioavailability.
Epilogue:
However, it should be noted that "it is a drug three points of poison", and metoprolol tablets are not suitable for all blood pressure diseases and cardiovascular diseases. So if you also have these diseases, you must go to the hospital for medical treatment and follow the doctor's guidance to take medication.
Patients taking metoprolol tablets at the same time must also pay attention to the precautions when taking the drug, and must not stop taking the drug at will. When you feel that the side effects of taking drugs are obvious, you must also seek medical treatment in time and change the drugs under the guidance of a doctor.