Recently, the international authoritative academic journal Circulation: Cardiovascular Imaging (Area 1 of the Chinese Academy of Sciences) reported online the latest research results completed by Dr. Chen Wensu, the cardiac electrophysiology team of Xuyi Medical Affiliated Hospital, and the team of Professor Kelle Sebastian of the Heart Center in Berlin, Germany: "Synthetic Extracellular Volume in Cardiac Magnetic." Resonance Without Blood Sampling: a Reliable Tool to Replace Conventional Extracellular Volume”。
Cardiac magnetic resonance imaging is currently the most promising cardiac evaluation tool, and extracellular volume (ECV) is an important indicator of myocardial fibrosis, known as the "non-invasive biopsy" of myocardium. However, the acquisition of magnetic resonance ECV requires the collection of blood samples from patients within 24 hours, which greatly reduces its clinical applicability. In this study, 1101 patients were enrolled, and through the establishment of mathematical models, an effective method of obtaining ECVs without a blood sample was derived, and the high accuracy of the new method was verified. The establishment of the bloodless ECV model has greatly promoted the clinical promotion of non-invasive assessment technology for myocardial fibrosis, which not only reduces the blood collection process of patients, saves costs, simplifies the examination process, and realizes real-time ECV-Mapping technology, but also promotes the real application of "non-invasive biopsy" to clinical practice, thus benefiting the majority of patients.
In addition, another of Dr. Chen's research results, "Ring-like late gadolinium enhancement for predicting ventricular tachyarrhythmias in non-ischaemic dilated cardiomyopathy," was featured in EHJ-Cardiovascular, a sub-issue of the European Journal of Cardiology, at this time last year Imaging (Area 1, Chinese Academy of Sciences). This study uses cardiac magnetic resonance imaging to screen out people with a high risk of sudden death from dilated cardiomyopathy, which provides an important assessment basis for the risk stratification of clinical sudden death.
Once published, this research result has received the attention of many international cardiovascular disease experts and has been reviewed in the current issue of the journal. The famous Spanish cardiovascular professor Antonio Berruezo therefore proposes that the era of stratification of EF values as a risk of sudden death may be over.
The study was also selected for the 42nd Annual Meeting of the American Heart Rhythm Association (HRS) 2021, for which Dr. Wensu Chen was awarded the annual Young Investigator Award Ceremony. The American Heart Rhythm Association is the world's most influential international conference in the field of electrophysiology, and a total of 7 scholars from China (including Hong Kong, Macao and Taiwan) have received this honor. The promulgation of this award indicates that the electrophysiology team of our institute has crossed a new level in the international field.
