Recently, the family doctor jun saw a lot of problems like this in the background, that is, they want to know the interaction between fruits and birth control pills. A newly married lady reader asked a question, recently citrus fruits on the market, she herself very much like to eat this kind of fruit, every day oranges, grapefruit eat non-stop.
Will grapefruit affect the effectiveness of short-acting contraceptives?
Grapefruit, also known as grapefruit, is a kind of grapefruit and is a very popular fruit. The claim that grapefruit affects short-acting contraceptives has been circulating for a long time, but there is actually some truth.
People who have carefully studied the drug instructions can see in the drug interaction column that among the drug substances that reduce the clearance of compound oral contraceptives, there is grapefruit juice, and grapefruit is grapefruit.
Researchers have found in grapefruit that furancoumarin is an ingredient that interferes with the action of cytochrome P450, inhibits certain drug metabolism enzymes, and affects drug metabolism. Short-acting oral contraceptives are metabolized once a day, and if grapefruit is eaten, it will affect the effectiveness of contraceptives, and it is likely that contraceptive failure may occur. If grapefruit is eaten during or within 28 days of stopping the short-acting oral contraceptive pill, additional contraceptive measures are needed.
What other drugs do grapefruit affect?
1. Antihypertensive drugs
People with high blood pressure need to take antihypertensive drugs every day to control their blood pressure, and grapefruit is also a fruit they need to avoid. Grapefruit can significantly increase the bioavailability of nifedipine and felotidipine antihypertensive drugs, which are very common antihypertensive drugs.
2. Lipid-lowering drugs
When eating lipid-lowering drugs, it is not suitable to eat grapefruit, grapefruit and other grapefruit, which will inhibit the metabolic enzymes of some common lipid-lowering drugs, and will make the drugs accumulate in the body, causing liver and kidney damage, and even lead to liver and kidney failure for a long time.
3. Sedatives
Grapefruit and sedatives are eaten together, which will prolong the metabolism of the drug, make the drug work longer, and will have symptoms of drowsiness, dizziness, headache and other uncomfortable symptoms. Especially professionals such as drivers, if groggy, are prone to danger.
4. Immunosuppressants
Tacrolimus is a type of immunosuppressant that is often eaten with grapefruit and carries a risk of developing tumors. The same is true of cyclosporine A, which is eaten with grapefruit, which will accelerate absorption, increase blood concentrations, and have stronger liver and kidney toxicity.
5. Anti-allergic drugs
If there is an allergic reaction, you need to take anti-allergic drugs, and during the medication, it is not suitable for eating grapefruit. Especially tefenadine, eating together can cause tachycardia, which is very dangerous and requires caution.
What drugs can be taken with contraceptives to reduce adverse reactions?
1. Vitamin C
When you go to the pharmacy to buy contraceptives, the teller will recommend buying vitamin C together. It's not just a sales pitch, the two drugs can be taken together and can reduce the chance of blood clots.
2. Vitamin B6
When you first start taking short-acting oral contraceptives, some people will have nausea, want to vomit and other reactions similar to early pregnancy reactions, at this time, you can take vitamin B6 to relieve.
3. Vitamin E
Vitamin E can improve female fertility and physiological ability, if you are worried that long-term contraceptive pills will affect fertility, you may wish to supplement with vitamin E.
4. Folic acid
Long-term use of contraceptives, the amount of folic acid in the blood will decrease, so the chance of anemia will be greater than that of people who do not take contraceptives. Folic acid supplementation at the right time can prevent anemia.
Grapefruit is a fruit that affects the functioning of many drugs, and many drugs interact with each other, and contraceptives are one of them. Whether you are taking emergency contraceptives or short-acting oral contraceptives for a long time, stay away from grapefruit and avoid eating grapefruit as much as possible. You can take vitamin C, vitamin B6, vitamin E, and folic acid to reduce adverse reactions, prevent diseases, and let people have no worries.
Family doctor online special article, unauthorized reproduction