Huazi has always encountered people who come to consult avanafil recently, and the common question is, what are the characteristics of avanafil, and what special attention is needed when taking it?
Huazi said that in terms of pharmacological classification, avenafil is a type 5 phosphodiesterase (PDE5) inhibitor, which was listed in the United States in April 2012. It is characterized by a faster onset of action and lower adverse reactions.
First, the mechanism of PDE5 inhibitors in the treatment of ED
Many middle-aged and elderly male friends will encounter the problem of male erectile dysfunction (ED). The causes of ED are more complex, there are psychological reasons, such as excessive pressure, excessive tension, etc.; there are also physiological reasons, such as sedentary, too little exercise caused by the decline in physical fitness, etc.; there are pathological reasons, such as arterial stenosis caused by "three highs", which affect blood perfusion.
In the blood perfusion process of organs, cyclophosphoguanosine (cGMP) is an important "cell messenger", transmitting information that dilates muscles and increases the amount of blood perfusion. PDE5 inhibitors can reduce the destruction of cGMP, increase its levels, thereby relaxing the smooth muscles of the cavernous body, increasing blood flow perfusion, and improving ED symptoms.
Second, avanafil has the fastest onset of action
In the process of use of previous generations of PDE5 inhibitors, many patients reported that they did not grasp the "timing of taking the drug". Because the drug needs to be absorbed from the time it is taken to the time it takes effect. Previous generations of PDE5 inhibitors typically took about 1 to 2 hours to reach their maximum peak concentration.
However, many patients do not want to have too long waiting time after taking the drug, and want to quickly achieve the effect of "medicine to disease" after taking the drug. Among PDE5 inhibitors, alvanafil is absorbed the fastest after oral administration, with an effect of about 15 minutes and a maximum concentration of 30 to 45 minutes. You can take the medicine "when you need it" and see results quickly, without waiting long.
Third, the side effects of avanafil are low
When using PDE5 inhibitor drugs, the reason for the patient to stop the drug is mainly the intolerable adverse reactions that occur during the medication. Common symptoms include headache, facial flushing, sinusitis, nasal congestion, indigestion, back pain, visual impairment, muscle pain and other symptoms.
In adverse reaction trials, the incidence of arvanafil syndrome adverse reactions was reduced by more than half compared with previous generations of PDE5 inhibitors. Even when present, the vast majority are mild reactions, do not require treatment or special treatment, and do not affect the continuation of the drug.
Fourth, the metabolic rate of avanafil is fast
Compared to other PDE5 inhibitors, avanafil is metabolized the fastest. Some people may ask, the fast metabolic rate means that the duration of the drug is short, will it affect the persistence, is this the disadvantage of the drug? In fact, from a pharmacological point of view, the rapid metabolism of avenafil is its advantage.
Because from the perspective of the purpose of medication, it is not necessary to maintain the efficacy of the drug for a long time. The rapid rate of drug metabolism means that the possibility of accumulation poisoning is small, reducing the possibility of congestion for too long and causing local tissue necrosis. Therefore, drugs with fast metabolism are relatively safer.
Fifth, what to pay attention to when using avanafil
The first use of avanafil begins with a low dose (100 mg) and is taken 15 minutes in advance when needed. After that, with the reaction of your own body, you can increase the dose (maximum 200 mg) or reduce the dose (50 mg). Be careful not to take the medicine more than once a day.
We need to understand that there needs to be a corresponding stimulus for blood vessels to release nitric oxide (NO) in order to activate the NO-cGMP pathway and increase the release of cGMP. The drug can reduce the destruction of cGMP, but does not increase the release of cGMP, and if there is no corresponding stimulation, no NO is present, taking the drug will not produce an effect.
Nitrates (nitroglycerin, isosorbide nitrate, etc.) increase the release of NO, which, when combined with PDE5 inhibitors, causes the blood vessels to dilate violently, causing severe hypotension. Therefore, when taking nitrate drugs, avanafil should not be taken. More than 12 hours of intervals are required before the medication can be administered.
Patients with severe hepatic and renal insufficiency, blood pressure is too high (more than 170/100mmHg) or too low (less than 90/50mmHg), can not be used. The activities carried out after medication have the potential to induce cardiovascular and cerebrovascular accidents, so those who are at risk of cardiovascular and cerebrovascular diseases should be taken with caution.
To sum up, among phosphodiesterase type 5 (PDE5) inhibitors, avanafil has the fastest onset of action, lower side effects, and faster metabolic rates. The control of the use time is more flexible, and it can be "used and served". In the process of medication, it is necessary to beware of the effect of combination with other drugs, and pay attention to the relevant contraindications when using. Medications should be used under the guidance of a doctor, if you have any doubts about medication, please consult a doctor or pharmacist. I am a pharmacist Huazi, welcome to follow me and share more health knowledge.