A friend consulted Huazi, and he saw a document saying that avenafil can be used for the treatment of male infertility, what is this drug and what is its effect? Hanako tells him that avanafil is the same drug as the familiar sildenafil used to treat erectile dysfunction (ED) in men.
There are many male infertility patients whose sperm quality is normal, but because of the appearance of ED or premature ejaculation, it is impossible to complete the couple's life, resulting in infertility. Therefore, clinically, doctors will recommend the use of avarnafil for the treatment of ED, and dapoxetine for premature ejaculation for adjuvant treatment of male infertility.
First, avanafil can be used for male infertility
Avanafil is a new generation of phosphodiesterase type 5 (PDE5) inhibitors, which are similar to previous generations of sildenafil, tadalafil, and vardenafil. The inhibition of PDE5 increases the level of cyclophosphate guanosine (cGMP), prompting relaxation of the smooth muscles of the cavernous body to cause increased perfusion and erection.
The use of PDE5 inhibitors can significantly improve ED symptoms, while there is no PDE5 gene and protein expression in the testicles of men, so the use of PDE5 inhibitors has no effect on the morphology and motility of sperm. Can be used for adjuvant therapy of male infertility without reproductive toxicity.
Second, what are the characteristics of Avanafil
One might wonder why we have developed alvanafil already have several PDE5 inhibitors? This is because avanafil has its own unique advantages because it has a different chemical structure from other similar drugs.
Fast onset of action: Alvanafil acts quickly, about 15 minutes after oral administration, and the medication is not affected by diet. Compared with other similar drugs, sildenafil (60 minutes), tadalafil (25 minutes), valdenafil (30 minutes), the use of avanafil can make yourself "ready" faster.
Low adverse reactions: When using PED5 inhibitors, adverse reactions such as headache, flushing, nasal congestion, indigestion, back pain, visual impairment, and hypotension are the biggest problems for patients. In clinical trials, avanafil had the lowest incidence of adverse reactions.
High safety: Among PDE5 inhibitors, alvanafil metabolizes the fastest, meaning that the drug is less prone to accumulated toxicity and is relatively safer.
Third, what to pay attention to when using avanafil
1. Dosage: There are two specifications of avanafil, which are 100mg and 200mg. If applied for the first time, it is recommended to choose a low dose of 100 mg, just take it 15 minutes in advance.
According to the effect and tolerance after taking the drug, if the effect has not reached the ideal state, it can be increased to 200 mg, or reduced to 50 mg, and the frequency of taking the drug is once a day.
2. The key to action: Avanafil plays a role by reducing the damage of cGMP and increasing its level. However, sexual stimulation is needed to promote the release of the vasoactive factor nitric oxide (NO) to activate the NO-cGMP molecular pathway. That is to say, the onset of action after taking the drug requires sexual stimulation, otherwise the drug will not exert its effect.
3. Interaction with other drugs: nitrate drugs can promote NO release, and after combining with avanafil, it will lead to severe hypotension and need to be disabled. Those who use avanafil need to be separated by more than 12 hours before nitrates can be used.
Avanafil is metabolized by the liver drug enzyme CYP3A4, and if CYP3A4 inhibitors (ketoconazole, ritonavir, atzanavir, clarithromycin, indinavir, itraconazole, nefazodone, nefenavir, saquinavir, and telithromycin, etc.) are used at the same time, alvanafil needs to be contraindicated.
3. Contraindications: allergic to this product, disabled in patients with myocardial infarction, stroke or life-threatening arrhythmia within 6 months; disabled when blood pressure is lower than 90/50mmHg, or higher than 170/100mmHg; severe angina, severe hepatic and renal insufficiency is disabled.
It is contraindicated in patients with hereditary degenerative retinal disease and non-arterial anterior ischemic neuropathy (NAION) leading to monocular vision loss.
To sum up, avanafil is a new generation of PDE5 inhibitors used to treat ED and can also be used as an adjunctive therapy for male infertility. Compared with previous generations of PDE5 inhibitors, avanatafil has a faster onset of action, a lower incidence of adverse reactions, and a smaller accumulation of more safe. However, when using, it is necessary to pay attention to the interaction with other drugs and contraindications.
Medications should be used under the guidance of a doctor, if you have any doubts about medication, please consult a doctor or pharmacist. I am a pharmacist Huazi, welcome to follow me and share more health knowledge.