On February 16, the latest data released by the World Health Organization showed that the number of confirmed covid-19 cases worldwide fell by 19% last week, and the number of new cases remained stable. Who said there were more than 16 million new infections and around 75,000 deaths worldwide last week. With the exception of Omikeron, cases of infection with all other mutant strains are declining, as they have all been replaced by Omikeron.
Omikron 丨 Figureworm Creative
Abdi Mahmoud, WHO's COVID-19 response officer, noted that "the world thinks the Olmikron variant is mild, but ignores the fact that it has killed 500,000 people since its discovery", a fact that has occurred after the advent of a COVID-19 vaccine that has been proven effective is "really sad".
The Omiljun strain has become a major epidemic strain worldwide
From the more than 430,000 genome sequences of the new coronavirus recently collected by the Influenza Data Sharing Global Initiative platform, about 98.3% are Omilon strains, and Delta strains account for only about 1.7%.
Currently, the Olmiqueron strain has replaced the Delta strain as the main epidemic strain worldwide, including the B.1.1.529 lineage and its descendants BA.1, BA.1.1, BA.2 and BA.3. So far, the number of BA.1 strain infections has accounted for the vast majority of global Omiljung virus infections, but the proportion of BA.2 strain infections is increasing, reaching 21.09% as of the fifth week of 2022. As of 14 February, the sub-variant strain has become the main epidemic strain in 10 countries and territories.
On 15 February, WHO noted in its weekly epidemiological report on COVID-19 that earlier research data suggest that the Aumikojungya variant BA.2 strain is more susceptible to transmission. Based on danish epidemic data, the sub-variant was 30% more contagious than the original Strain of Omikeron, BA.1, but the severity of the disease it caused was no different from that of the original Omikeron strain.
The Omikejunn mutant strain is highly transmitted
On February 9, 2022, according to Science and Technology Daily, researchers at Pennsylvania State University in the United States said that the new coronavirus Semicon variant strain was found in the White-tailed Deer in New York, which is the first time that the Aumequeron variant strain has been found in wild animals.
On February 8, 2022, Xu Huaqiang and Yin Wanchao's team at the Shanghai Institute of Materia Medica of the Chinese Academy of Sciences published an article titled Structures of the Omicron Spike trimer with ACE2 and an anti-Omicron antibody, successfully resolving the Omiljung mutant spike protein.
FIG.1 High-affinity binding of the SARS-CoV-2 Omicron spike protein with human ACE2. (High affinity of SARS COV-2 OmiCron spike protein binding to receptor ACE2)
Therefore, whether it is a vaccine or the immune system after the human body is infected with a virus, most of it is a response to the spike protein of the strain, the more mutations on the spike protein, the higher the affinity of the binding receptor, the easier it is for the mutant strain to invade the human body, and the more likely it is to escape the vaccine against the original spike protein.
The innovative development of vaccines is the key point of epidemic prevention
On February 16, 2022, the ARTICLE COVID-19 vaccine boosters in the Asia-Pacific region in the context of the context of the Omicron, published at THE LANCET by John D Hart's team from the Murdoch Children's Research Institute, discusses the prevalence of the Aumicorejung variant. The global supply of vaccines will face inequalities, and the Coalition for Epidemic Preparedness Innovations has evaluated small doses of booster injections to address these issues.
Immune effect studies have shown that half-dose Pfizer/BioNTech or Moderna vaccine booster needles induce high-school and antibodies against variants, and even lower doses of intradermal administration can show promising results.
There is clear evidence that older adults and immunocompromised populations need a third dose of the vaccine to prevent any variant.
However, in managing the boosters, the first priority remains to vaccinate the world's highest proportion of qualified people who have been vaccinated with two doses. At the same time, efforts should be made to explore new dosing strategies to reduce the need for vaccine quantities in order to alleviate vaccine shortages.
The principle of life first is the belief in the long-term fight against the epidemic
At the first Greater Bay Area Science and Technology Forum on December 11, 2021, Academician Zhong Nanshan mentioned that the prevalence of the epidemic in China is 9 per 100,000, compared with the United States, our is 1/1687 of the United States; our case fatality rate is 0.4 per 100,000, which is 1/619 of the United States. Zhong Nanshan believes that in order to control the epidemic more quickly, it is imperative to do three things at present: one is to achieve herd immunity through vaccination, and to improve antibody levels through vaccination to strengthen needles; second, to continue to increase research on new crown drugs; and third, to call for global cooperation and technology to defeat the epidemic.
Xu Wenbo, director of the Institute of Viral Disease Pre-release Control of the Chinese Center for Disease Control and Prevention, once explained that the mainland's general strategy of "external prevention of imports, internal prevention of rebound" and the general policy of "dynamic clearance" are still valid for the Aumechjong variant. Moreover, the Chinese Center for Disease Control and Prevention has established a specific nucleic acid detection method for the Omiljunn variant, and continues to carry out viral genome surveillance for possible imported cases and associated native cases, which is conducive to the timely detection of Omilcroon variants that may be imported or associated with the local.
Recommendations of the World Health Organization for responding to the Opichron variant
The World Health Organization recommends that countries strengthen surveillance, reporting and research on COVID-19 and take effective public health measures to interrupt the spread of the virus. Individuals are advised to stay at least 1 metre apart in public places, wear a mask, open windows for ventilation, keep their hands clean, cough or sneeze on elbows or tissues, vaccinate, etc., and avoid going to poorly ventilated or crowded places. Currently, all variant strains can cause severe illness or death. Therefore, preventing the spread of the virus is always key, and the NEW Crown Virus vaccine remains effective in reducing severe illness and death.
Author: Li Tong
Source: Clinical Frontline
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