Xiaolin (pseudonym), 31, gave birth to a nearly 7-kilogram "little beauty" at the Hainan Obstetrics and Gynecology Hospital. Strangely enough, both husband and wife have type O blood, but the newborn daughter is type B blood!
When ordinary male compatriots encounter this kind of problem, they will unconsciously emerge two kinds of thoughts:
Dog blood plot, the child was born with the wrong hug.
The child belonged to the old king next door, and his head was green.
This dad is no exception. After ruling out the possibility that the newborn was holding the wrong hug in the delivery room, Bao Dad wondered in his heart: "Is the wife cheating?" ”
Therefore, he ignored the fact that his wife was still confinement, and even just after the struggle with the god of death, there was a quarrel, and his wife was helpless and finally agreed to a paternity test.
The staff of the Laboratory Department of Hainan Obstetrics and Gynecology Hospital sent the blood samples of the two to the blood testing agency for gene sequencing, and finally determined: Mom is a mother, and Dad is also a father!
The reason why the B blood type baby was born was because baoma's FUT1 gene had heterozygous mutations of 551-552delAG and 881-882delTT, both of which caused H antigens not to be expressed, and Kobayashi belonged to the "Mumbai-like blood type".
What is the "Mumbai-like blood type" that caused the trouble?
The Mumbai blood type was first discovered in Mumbai, India, in 1952 by Y.M.Bhende, so it is called the Mumbai blood group, which is essentially a lack of H antigen. In 1961, some scholars discovered a blood type similar to the Mumbai blood type, called the "Mumbai-like blood type", that is, the Sub-Mumbai blood type, which is a branch of the Mumbai blood type.
The "Mumbai-like blood type" is a special blood type that is rarer than panda blood, and the proportion of people with this blood type in the country is only one in hundreds of thousands, and only about 30 cases have been reported in China.
Although the mother in this news shows that it is type O blood, the antigen on the red blood cells contains the B gene. The baby got the gene containing B blood from the Mumbai-like mother, and the gene from the father's O blood type, so it was BO blood, which was manifested as B blood.
This phenomenon is very rare, generally this blood type we can not identify in the blood group identification, the blood type results of the test showed O type.
Genetic patterns of ABO blood type
In medicine and genetics, people often use the blood type of their parents to infer the blood type of their children. Among them, the ABO blood group system is the most familiar and extremely important blood group system in blood transfusion.
Therefore, Bao Dad's doubts are not unreasonable - from the conventional ABO blood type cognition, parents with O blood type can indeed not give birth to children with B blood type.
With only a general blood type test, we will be very suspicious of the baby's B blood type. But after genetic testing, we found that Bao Ma belonged to the Mumbai-like blood type. Without genetic testing, it is easy to suspect that the baby is not biological.
Why is DNA polymorphism testing recommended?
With the advancement of medicine, more and more cases of genetic abnormalities of ABO blood group and DNA polymorphism detection and affirmation of parental blood relations have been reported, so it is obviously unwise to exclude parent blood relations based on violation of ABO blood group genetic laws, and DNA polymorphism detection should be used as the criterion.
I sincerely hope that every gentleman can give the pregnant mother the most basic trust, the woman is pregnant in October, and hopes to have someone who understands you.
remind
In general, the blood type is unchanged for life.
If the baby needs to use blood, such as the AB subtype, the blood type A has been transfused, and once the transfusion reaction occurs, the medical conditions are limited, and it may be life-threatening in severe cases.
So for people with rare blood types, such as the Mumbai blood type, which is a special case, what should be done if blood transfusions or urgent blood are needed? Now under the problem of blood shortage, like the author's area, even the most basic type B blood is particularly lacking, not to mention special types of blood.
Therefore, usually you need to consider the situation that you may need to use blood urgently, such as the process of giving birth, the surgical process, etc., try to enter the local rare blood type exchange group, and when you need to use blood, you can say hello in the group in advance and help each other in order to live every day safely.
In life, minimize the occurrence of accidents, because it is particularly difficult to get blood transfusions. Even pregnant mothers with some blood diseases should find out whether the fetus is abnormal as soon as possible and decide whether the fetus will go or stay.
【Reference】
Pan Yingfang. XU Qun. SUN Changkui. SONG Yonghong. LI Jing. LV Hongjuan. ZHOU Na. Joe Text. Identification of clinically rare Mumbai-like blood group tests. Shandong Medicine. DOI:10.3969/j.issn.1002-266X.2020.09.010.
Tang Meiyun. SHENG Xiaoqi. HUANG Jian. ZHAI Zhixiong. A case study of the inheritance of ABO blood group abnormalities. Advances in Modern Biomedicine, No. 15, 2009, 2866-2868, 3 pp.
Source: Pediatrics Channel of the Medical Professions
Edited by: Yeah Reviewer: Xiao Ran