After the non-bustetin lowers the uric acid normally, the drug is discontinued, and the uric acid will be retaliatoryly elevated! Benzbromarone lowers uric acid, and after a long time, you will get kidney stones! Why?
Recently, people have been asking continuously that they insist on using nonbutexta to lower uric acid, drop to less than 300 for a period of time, stop taking, and find that uric acid is actually retaliatory, even higher than before taking, why is this? How to avoid it?
There are also gouters who take benzbromomarone, saying that they insist on eating benzbromomarone for two months, and the uric acid has led to a lot of drops, but a few days ago to recheck, the result was that they found that they had kidney stones in both kidneys and urinary tracts. Why? And what to do?
In fact, as long as you know the principle or mechanism of non-bustata and benzbromomarone in lowering uric acid, you cannot understand the above two phenomena.
Febuxtastat reduces uric acid in the body by inhibiting the metabolism of purines into uric acid in the body. Since non-buste does not allow purine metabolism to uric acid, uric acid is low, although the human body also has the function of active excretion of purines, but there are still some purines stuck in the body, forming a relatively high concentration of purines.
Once you stop taking febuxita, the new purines that are generated in the body every day and the purines that were originally nonbustastasy cannot be metabolized to uric acid, without an inhibition mechanism, are metabolized to uric acid in large quantities, resulting in elevated uric acid and even retaliatory increases.
And what about phenylbromarone?
Benzbromomarone is to inhibit the reabsorption of uric acid by the glomeruli to promote uric acid excretion, since the glomerular reabsorption of uric acid is less, then the kidneys, especially the urinary tract in the uric acid concentration is relatively high, if the PH value of the urine is relatively low, the urinary acid concentration in the urinary tract is easy to exceed saturation and crystallize precipitation, forming kidney stones and urinary tract stones.
So what to do?
1. Drink a lot of water every day, not less than 2 liters, so as to maintain the amount of urine, you can dilute the urine to improve the pH of the urine, improve the solubility of uric acid and promote the excretion of uric acid. Adequate urine is also conducive to the excretion of purines in the body.
2. If there are kidney stones, it is not recommended to use benzbromarone to lower uric acid.
3. If taking benzbromomarone, it is strongly recommended to alkalize the urine at the same time, increase the PH value of the urine, and avoid the precipitation of uric acid crystals to form stones.
4. Alkalized urine can choose sodium bicarbonate or citrate compound similar to Zhengxiaojian electrolyte.
Citrate preparations alkalinize urine and at the same time dissolve already formed stones and prevent the formation of new stones.
Because citrate, a strong inhibitor of stones naturally occurring in the human body, can not only inhibit urate stones, but also inhibit the formation of calcium oxalate and calcium phosphate stones.
In short, our goal is: uric acid is no longer high, gout will not be committed, and away from uric acid stones. #哪些人容易得肾结石?##Healthy New Year##哆咖医生超能团 #
Citrate blend is a small health electrolyte
