The top ten academic progress of traditional Chinese medicine in 2021 were released, and new progress in the creation of "three parties" was selected

The results of the selection of "2021 Top Ten Academic Progress in Traditional Chinese Medicine" organized by the Chinese Association of Traditional Chinese Medicine were released! What breakthroughs have been made in the field of traditional Chinese medicine? Let's take a look at it~ ~~

The neuroanatomical mechanism of electro-needle-driven vagus-adrenal axis anti-inflammatory was discovered

A joint study by Harvard University, Fudan University, the Institute of Acupuncture and Moxibustion of the Chinese Academy of Chinese Medical Sciences and the Fujian University of Traditional Chinese Medicine found that the stimulation of electro-acupuncture in a mouse model of sepsis to stimulate the "Foot Sanli" acupuncture point (ST36) of the hind limbs can activate the PROKR2-Cre labeled dorsal root ganglion sensory neurons, which can regulate the vagus nerve-adrenal reflex and inhibit the inflammatory response, thus finding the basis for modern neuroanatomy for electric acupuncture to stimulate the "Foot Sanli" acupuncture point to exert the anti-inflammatory effect of the whole body.

New progress has been made in the creation of new Chinese medicine drugs such as lung detoxification granules, wet septic granules, and lung sepsis granules

On March 2, 2021, based on the "three parties", the new Chinese medicine drugs clearing the lungs, detoxifying the poison particles, and the lung sepsis granules were approved by the State Drug Administration. The anti-epidemic "three parties" are all innovated on the basis of ancient classic recipes, and their listing has also opened up a new mechanism for the creation of new drugs in traditional Chinese medicine, which is a typical example of the transformation of the original advantages of traditional Chinese medicine.

New progress has been made in the basic biomedical research of the theory of "emotion causing disease"

Professor He Rongrong's team from Jinan University School of Traditional Chinese Medicine/School of Pharmacy and Professor Chen Jiaxu's team studied the biomedical basis of emotional pathogenesis theory from the innovative perspective of "emotional stress" to increase the "susceptibility" of diseases, established a variety of disease susceptibility research models that meet the characteristics of traditional Chinese medicine, and revealed that the main effectors of emotional stress are stress hormones and oxidation molecules, causing the peroxidation of the effect target unsaturated phospholipids, thereby increasing the sensitivity of lipid peroxidation death mode of stress cells. The biomedical basis for emotional stress to increase susceptibility to diseases such as Parkinson's disease and breast cancer is analyzed.

Acupuncture for chronic prostatitis/chronic pelvic floor pain syndrome yields evidence of high-quality clinical studies

Through 440 randomized controlled trials, the research team of Professor Liu Zhishun of Guang'anmen Hospital of the Chinese Academy of Chinese Medical Sciences confirmed that acupuncture can significantly improve the symptoms of patients with moderate to severe chronic prostatitis/chronic pelvic floor pain syndrome, and the clinical effect can last for at least half a year after the end of treatment. This study fills the gap in the lack of long-term efficacy of international acupuncture for chronic prostatitis/chronic pelvic floor pain syndrome.

The Materia Medica genome database based on the multinational pharmacopoeia was launched

Professor Chen Shilin's research team from the Institute of Chinese Materia Medica of the Chinese Academy of Chinese Medical Sciences completed the construction of the Materia Medica genome database and launched it according to the multi-national pharmacopoeia to include herbal species. The database is the world's first large-scale genomics database for medicinal species included in the pharmacopoeia, which can provide information support for herbal species identification, drug safety, analysis of biosynthetic pathways of pharmacodynamic ingredients, and molecular breeding of excellent varieties.

Scientific decoding of TCM allergy/flat constitution difference targets fused with biosensing AI algorithms

Professor Wu Zhisheng's research team of Beijing University of Chinese Medicine used clinical real-world samples as the research carrier to create the key technology integration of semiconductor material chips, new artificial intelligence algorithms, molecular docking and zebrafish biological models, which realized the integration of biological sensing and artificial intelligence algorithm technology based on traditional Chinese medicine (allergy) constitution for the first time, and further provided differentiated evidence of allergic constitution and peace and physique, as well as differentiated evidence of allergic constitution before and after the intervention of allergy kang. For the first time, the intelligent identification of the key quality attributes of Chinese medicine compound based on the constitution of traditional Chinese medicine (allergy) has been realized, which provides new scientific evidence for the differentiation of constitution and the adjustment of constitution.

The national standard system for traditional Chinese medicine formula granules has been initially established

In February 2021, the "Technical Requirements for Quality Control and Standard Research of Chinese Medicine Formula Granules" was officially released, which for the first time established a quality control system for Chinese medicine formula granules with standard decoction as a reference and its process optimization strategy, providing a scientific basis for the establishment of quality control in the whole process that meets the characteristics of Chinese medicine. In April and October 2021, the State Drug Administration promulgated 196 national standards for clinically used Chinese medicine formula granules. The construction of this standard system solves the problem that there is no national standard for Traditional Chinese medicine formula granules for more than 20 years, and ensures the safety and effectiveness of clinical drugs.

New progress has been made in the international standardization of traditional Chinese medicine

The standardization of traditional Chinese medicine is an important part of the academic development of traditional Chinese medicine, and it is of great significance to promote the standardization of key issues in the field of traditional Chinese medicine in a healthy and orderly manner. In 2021, some important progress has been made in the field of standardization of traditional Chinese medicine: ISO has officially issued two international standards for the terminology of traditional Chinese medicine diagnostic terms, "Traditional Chinese Medicine - Diagnostic Vocabulary - Part I: Tongue Image" and "Traditional Chinese Medicine - Diagnostic Vocabulary - Part II: Pulse Image"; the World Federation of Chinese Medicine Societies has issued the "Guidelines for Network Pharmacological Evaluation Methods" (SCM0061-2021), and the research work of Chinese medicine network pharmacology has a reference specification.

The scientific connotations of qi deficiency and gas fixation based on the microvascular barrier have been preliminarily revealed

Professor Han Jingyan's research team at Peking University Medical College found that the ability of vascular endothelial cells to produce ATP using acquired qi (oxygen and water valley subtlety) was reduced, and the vascular barrier damage (including endothelial gap opening, plasma membrane microcyst increase, and basement membrane damage) was the pathogen of microvascular leakage; the prescription drug for replenishing qi and activating blood (Qi Ginseng Yiqi, Yiqi Compound Pulse) could improve the ATP synthase of the mitochondria of vascular endothelial cells, increase ATP content, improve the vascular barrier, and inhibit microvascular leakage and edema. The scientific connotation of qi deficiency and non-fixation and replenishment of qi solid regency is clarified, and a new strategy for the treatment of edema is innovated.

The neuro-immune anti-inflammatory mechanism of electro-acupuncture to improve postoperative intestinal palsy was initially revealed

For the first time, the research team of Professor Liu Cunzhi of Beijing University of Traditional Chinese Medicine has systematically revealed the neuro-immune response pathway of electro-acupuncture stimulation of foot sanli acupuncture to improve postoperative intestinal palsy, confirmed that the anti-inflammatory effect of electro-acupuncture has acupuncture point specificity and frequency specificity, and explained the modern scientific connotation of acupuncture theory "hezhi neifu". The study also provides a scientific basis for the integration of acupuncture therapy into the clinical routine treatment of the perioperative period, and initially forms a perioperative management plan with Chinese characteristics.