"War Pox Little Master" Adapalene, 4 major precautions please check!

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Adapalene belongs to the class of tretinoins and is often used clinically in the treatment of acne. What are the precautions for Adapalene? Let's take a look at the small medicine with the world.

Precautions

1

UV and environmental exposure

■ During the use of adapalene, exposure to sunlight or ultraviolet lamps should be minimized.

■ Patients who are often exposed to a lot of sunlight exposure, as well as those who are naturally sensitive to sunlight, should be cautioned about taking the drug.

■ When it is not possible to avoid sun exposure, it is recommended to use sunscreen products and protective clothing in the area where the drug is treated.

■ In extreme weather, such as wind or cold, patients receiving adapalene treatment may also be stimulated.

2

Local skin reactions

Treatment with adapalene has been reported to present with certain skin signs and symptoms, such as erythema, peeling, dryness, and tingling/burning.

These symptoms are most likely to occur in the first 4 weeks of treatment, are mostly mild to moderate intensity, and usually lessen with continued use of the drug.

Depending on the severity of these side effects, patients should be instructed to use moisturizers, reduce the frequency of adapalene use, or discontinue adaparene.

Avoid contact with eyes, lips, nose corners and mucous membranes. Adapalene should not be used on cut, abrasions, eczema or sunburned skin.

As with other vitamin A-like products, the use of wax hair removal methods should be avoided on skin treated with adapalene.

Since adapalene has the potential to cause local irritation in some patients, other topical products that may be irritating should be used with caution (medicinal or abrasive soaps and cleaners, soaps and cosmetics, products with a strong drying effect, and products containing high concentrations of alcohol, astringents, fragrances or lime).

3

Allergic / hypersensitivity reactions

During post-marketing use of adapalene, reactions characterized by symptoms such as itching, facial edema, eyelid edema, and swelling of the lips have been reported, at which time medication is required.

If patients develop anaphylactic or anaphylactoid reactions (e.g., rash, pruritus, urticaria, chest pain, edema, and shortness of breath) during treatment, adapalene should be discontinued and a physician consulted [2].

Other considerations

1. The drug can only be used under the guidance of a doctor.

2. The dosage should not exceed the recommended dose, the number of daily uses should not exceed 1 time, multiple uses will not increase the efficacy, but may increase the stimulation of the affected area.

3. Once a night, after gently washing the skin, apply adapalene to the affected skin area.

4. Moisturizer can be used if necessary. Products containing α hydroxyl or glycolic acid should be avoided.

5. Eye contact with the drug may cause reactions such as swelling, conjunctivitis and eye irritation.

6. During the first few weeks of treatment, there may be a pronounced acne exacerbation. This may be due to the fact that the drug acts on a previously unseen lesion and does not justify the cessation of treatment. An overall clinical benefit may be noted after 2 weeks of treatment, but it takes at least 8 weeks to achieve a sustained beneficial effect.

7. For external use only [1-5].

bibliography:

[1] Product Information: ADAPALENE cream, E. Fougera & Co.a division of Fougera Pharmaceuticals Inc.,Updated August 18, 2021

[2] Product Information: ADAPALENE gel,Alembic Pharmaceuticals, Inc., Updated June 22, 2020

[3] Product Information: ADAPALENE gel, Glenmark Pharmaceuticals Inc., USA, Updated October 20, 2021

[4] Product Information: ADAPALENE TOPICAL SOLUTION solution, Allegis Holdings LLC,Updated December 10, 2020

[5] Product Information: DIFFERIN- adapalene gel, Galderma Laboratories, L.P., Updated September 15, 2020

This article was first published: Clinical Pharmacy Channel of the Medical Community

Author: Jie Xiao Yao

Editor-in-Charge: Little Dangdang

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