The Evening News | Omilon swept the globe and was able to escape most of the known neutralizing antibodies

1. National Health Commission: 158 new local cases were added on the 25th

From 0 to 24:00 on December 25, 31 provinces (autonomous regions and municipalities directly under the Central Government) and the Xinjiang Production and Construction Corps reported 206 new confirmed cases. Among them, there were 48 imported cases (18 cases in Shanghai, 8 cases in Tianjin, 5 cases in Guangxi, 4 cases in Yunnan, 4 cases in Shaanxi, 3 cases in Fujian, 2 cases in Hunan, 2 cases in Guangdong, 1 case in Beijing, and 1 case in Zhejiang), including 6 cases from asymptomatic infected people to confirmed cases (3 cases in Shaanxi, 2 cases in Guangxi, and 1 case in Beijing); 158 cases in local cases (157 cases in Shaanxi, including 155 cases in Xi'an City and 2 cases in Xianyang City; 1 case in Guangxi, in Fangchenggang City). There were no new deaths. There were no new suspected cases.

2. 65 people infected with the Omiljung strain in Thailand have been confirmed

CCTV news client news, Thailand's Galasin Province health department revealed on the 25th local time that a couple returning from Belgium in the province caused a group infection of the Omiljung strain, and the number of infections has risen to 65 people.

It is reported that the two entered from Suvarnabhumi International Airport through the quarantine-free entry process on December 10, and the entry nucleic acid test result was negative. After that, the two began to move freely, successively entering and leaving public places such as Khon Kaen Airport, restaurants, government agencies, shopping malls, etc., and contacting more than 100 people. On the 15th, the two began to develop symptoms, and on the 21st, they were confirmed to be infected with the Omiljung strain. Since then, 106 people who have had close contact with the two people have been screened and 65 people have been found to be confirmed. This is the first case of mass infection of the Omiljung strain in Thailand.

3. Is it okay to mix the reinforcing injection? Zhang Wenhong team: more effective for Aumicron!

The test results released by the China Institute of Food and Drug Control show that after receiving 2 doses of inactivated vaccine, the neutralizing antibody titer of the pseudovirus of the Omilon variant was only slightly lower than that of the prototype strain, and the titer of the neutralizing antibody was 10 times higher than that of the neutralizing antibody after the three-dose inactivated vaccine.

On December 23, the team of Huashan Hospital of the National Center for Infectious Disease Medicine, led by Professor Zhang Wenhong, announced the results of the study on the Enhanced Immunization of the Olmikeron strain.

Studies have shown that on the basis of two inactivated vaccines, homologous and heterologous, that is, the third reinforcing needle of mixed injections, increased the body's ability to neutralize the strain by 8.07 times and 15.87 times, respectively.

At the same time, the neutralizing antibody titer for the original strain of the vaccine was increased by 4.24 times and 21.31 times. This suggests that reinforcement is effective against mutant strains, while mixed reinforcement injections are more effective.

4. "Nature" focused on 5 research papers, focusing on the effectiveness of vaccines and antibodies on Omikeron

Focusing on the assessment of the resistance of the new coronavirus variant Omicron to antibodies and vaccines, the latest focus of the internationally renowned academic journal "Nature" has launched 5 immunological papers such as he dayi, a well-known Chinese-American expert, to study and explore the effectiveness of various vaccines and antibodies on the Omilon variant of the new coronavirus.

According to the Nature paper, existing covid-19 vaccines and new coronavirus monoclonal antibodies (proteins that target and neutralize the new coronavirus) play a role in recognizing the spike protein of the new crown virus, which is also the site where the new crown virus uses to enter human cells. The Semikeron variant has about 32 mutations in the spike protein and is expected to soon replace the currently circulating Delta lineage, but the impact of the Omilon on existing therapies and vaccine efficacy remains unknown.

The 5 papers that have been launched in this collection have been peer reviewed and accepted by Nature.

The neutralizing activity of 19 monoclonal antibodies against the Omiljung variant spike protein was studied. The monoclonal antibodies tested included clinically approved therapeutic antibodies, and the results showed that 17 of the 19 monoclonal antibodies completely or partially lost their neutralization ability. Only two retain their neutrality activity. Another study showed how sensitive the virus is to nine monoclonal antibodies that are currently approved for clinical use or are still in development. It was found that the Omikejong variant was able to fully or partially resist the neutralization of all monoclonal antibodies in the experiment. Among them, 5 antibodies are ineffective against Omikeron; 2 antibodies have a neutralizing activity of Omiqueron about 20 times less than their activity against Delta; and 1 antibody has an activity of anti-Omiqueron about 3 times lower than that of Delta.

5. France's daily increase in confirmed cases has reached a new high

According to the statistics of the French Public Health Agency on December 24, as of 14:00 on the same day, there were 94,124 new confirmed cases of new coronary pneumonia in France in a single day, setting a new record for the number of new confirmed cases in a single day since the outbreak of the epidemic in the country, with a cumulative total of 8983760 cases; 167 new deaths, 122462 cumulative deaths.