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The accumulation of senescent cells is one of the important causes of aging in the body. However, while we can use a variety of epigenetic clocks to determine a person's physiological age, it is difficult to measure the physiological age of a cell, which greatly hinders the aging research that researchers can carry out at the cellular level.
Recently, American researchers have given a solution. They designed a new clock called scAge that makes the measurement scale of epigenetic age accurate to the cells, accurately measuring the "physiological age" of each cell. The results were published on December 9 in Nature Aging, a sub-journal of the top journal Nature for aging research.
The epigenetic clocks we currently use require measurements of a large number of cell samples to derive the physiological age of the body or a tissue. While such measurements are critical to aging research, they invisibly mask epigenetic differences between cells.
The birth of scAge solved this problem. scAge is essentially a probabilistic model, through a large number of methylation data training, it can be based on the methylation level in a cell, it can be inferred most likely to correspond to the physiological age, the accuracy is very high.
This new epigenetic clock, which is accurate to the cell, is expected to be used in a variety of anti-aging research in the future, opening up new ways to study biological aging from the single-cell level.
—— TIMEPIE ——
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