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Recently, this news has exploded in the field of anti-aging.
The study released by Chinese scientists in Nature Metablism is exciting.
The Chinese team of experts found that PCC1, a substance that can "accurately remove senescent cells", has a very good effect, extending the healthy life expectancy of mice by 64.2%.
(roughly equivalent to an age of 75–90 years in humans) had a 64.2% longer median post-treatment lifespan
If this is put on a person, it is too powerful, maybe living to 200 years old may not be a dream, of course, rats are not people, but we can also look forward to it.
I have written a lot of anti-aging articles before and shared a lot of relevant research at home and abroad, but I still can't help but be excited when I see this news.
This study proves that Chinese experts have also come to the forefront in the field of anti-aging, and that the really useful anti-aging technology, science to extend life, may be just around the corner.
Although many people are joking about "postponing retirement in the future", most people are still very excited.
After all, who wouldn't want to live a little longer?
Today, let's take a good look at the knowledge behind this research.
Removes senescent cells and prolongs lifespan
About senescent cells, zombie cells, we have introduced many articles before, interested new friends can go to see the related reading: want to reverse the age such as 18 years old? In addition to anti-aging, we also have to drive away these "zombie cells"...
Scavenging senescent cells, they live 35% longer, the most exciting anti-aging formula...
In fact, as early as the 1960s, microbiologists Leonard Hayflick and Paul Moorhead discovered that the replication ability of human cells is limited and does not proliferate indefinitely.
This inability to proliferate is defined as "senescence" at the cellular level.
In 2008, the "dark side" of senescent cells was discovered, and three research groups have found that senescent cells continue to secrete a series of inflammatory factors SASP in the process of accumulation in the body.
These inflammatory factors can lead to chronic inflammation, damage to surrounding healthy cells, and induce various diseases of old age.
Scientists have found that when young mice are transplanted with senescent cells, they die from various diseases caused by age.
Slowly, we came to know senescent cells, when you are injured or sick, healthy cells transform into senescent cells, and once the cells become senescent cells, they stop dividing.
They will also be like zombies, to endanger healthy cells, make trouble everywhere, drag healthy cells into the water, interested can go to see my video number of science, may be better understand.
What is the truth about aging?
The accumulation of senescent cells can induce chronic inflammation, bringing about cardiovascular disease, osteoporosis, arthritis, chronic obstructive pulmonary disease, cataracts and other geriatric diseases.
How to remove senescent cells?
In fact, many methods have been found to eliminate senescent cells, and James Kirland, a well-known expert in this field (also a collaborator in this latest research).
（James Kirkland）
A number of substances were found to clear senescent cells, and they were named: "Senolytics," a combination of "senescence( seno-) and "destruction ( - lytic) " .
In February 2016, a related study published in the journal Nature found that by senolytics to eliminate senescent cells, the average lifespan of normally senescent mice was extended by about 1/4 (17%-35%), and the longest reached 35%.
In February 2019, James Kirkland, in collaboration with collaborators at the University of Texas and Wake Forest University in North Carolina, released a human study.
(Research screenshot)
Subjects took 3 doses of oral medication per week, and after 3 weeks, patients could go further than before the trial began, and it was a miracle that they performed better on other fitness tests (such as getting up from a chair).
It also slows down the degradation of many aging-related organs, such as kidneys and heart, without obvious side effects.
The main components of Senolytics that can remove senescent cells are dasatinib and quercetin, lacquer, curcumin, etc., but dasatinib is a prescription drug and is not recommended to eat it for a long time.
Other ingredients also need to work together to have a good effect.
PCC1, which increases the lifespan of mice by 64.2%
The PCC1 discovered by Chinese scientists is a type of proanthocyanidin (opc), which is a grape seed extract. (Warm tips: it is useless to eat grape seeds directly, and the opc content of grape seed essence sold on the market is too low).
This latest study found that it has a range of effects, extending the lifespan of mice by 64.2%.
Let's take a look at the specific research content.
PCC1 efficiently removes senescent cells
It can induce mitochondrial dysfunction in senescent cells, allowing it to die.
PCC1 belongs to the flavonoid superfamily that scavenges free radicals, chelates metals and reduces the formation of hydroperoxides, with antioxidant properties attributable to the functional "-OH" group in the structure and its position on the flavonoid molecular ring.
After being induced by PCC1, senescent cells begin to apoptosis, a process mediated in part by NOXA and PUMA upregulation and associated with increased ROS production and mitochondrial dysfunction.
PCC1 promotes tumor regression and reduces chemotherapy resistance
At the same time, the researchers also found that PCC1 alone can only slightly prolong survival, does not change tumor growth and does not promote animal survival.
However, when PCC1 is used in combination with chemotherapy drugs (MITs), the effect is better, promoting tumor regression, reducing drug resistance, and has a significant synergistic effect.
PCC1, which delays the decline of physical function in mice
Senescent cells lead to physical dysfunction, and researchers have found that after it clears senescent cells, many of the body functions of mice improve, alleviating many pathological conditions in old age.
For example, slowing down the walking speed of mice, holding strength and suspension arm strength decreased, which is the benefit of delaying aging.
There are many good anti-aging effects in the study, we will not list them all, of course, the best effect is to extend the healthy life of mice by 64.2%.
Key Skinny Dragon said
Aging is an inevitable process, but some people age fast and some people slowly.
Some people look very young, but their physical function is not good, and they age in advance;
However, some people, despite their age, are still energetic and in good shape.
The accumulation of senescent cells in the body is one of the main causes of many geriatric diseases and chronic diseases, and now there are more and more cancers, which is also related to the longer and longer lifespan.
If you can effectively remove senescent cells, you can reduce the risk of many geriatric diseases and chronic diseases.
At present, there are better anti-aging methods: fasting, sugar cessation, anti-inflammatory and antioxidant (many), supplementing with enough nutrients, supplementing nad+, and today we are talking about the removal of senescent cells.
Finally, a warm reminder: PCC1 is a kind of proanthocyanidin (opc), only the product OPC content is super high, there is such a good effect, ordinary grape seed essence, may not reach such a high.
I consulted Dr. Sun, who shared a calculation method, for a person weighing 60 kilograms, about taking more than 326.5 mg of proanthocyanidins (OPCs) per day can reach the dose taken by mice in the experiment.
We recently had a product that would have an ultra-high content of PCC1, mostly whitening, that could be on the shelves soon.
Remember to pay attention to me Oh, I will always share the latest technology in the field of anti-aging, as soon as it goes online, I will inform you.