Fujian is rich in grapefruit
Autumn is the season when grapefruit comes to market in large numbers
But many people say that eating grapefruit will affect the efficacy of the drug
Is this really the case?
Let's take a look today
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When it comes to fruits that affect drug metabolism, the most famous is grapefruit, which is even considered the "public enemy of drugs". Grapefruit is very popular in Western European and American countries, so it is also called "grapefruit". But grapefruit and the grapefruit we usually eat can not be confused.
From the looks
The two types of grapefruit are not only different in size, but also in taste
Taxonomically
Grapefruit and grapefruit belong to the same family, but are of different species
Then the effect on the efficacy
Is there also a difference between the two?
The reason why grapefruit will affect the efficacy is because many drugs in the human body need to be eliminated by enzyme metabolism, but grapefruit contains furan coumarin derivatives, which have a strong ability to bind to this enzyme, once this enzyme is "bound", then the active ingredient of the drug that needs to be metabolized by this enzyme stays in the body for a long time, causing changes in blood concentration, and the high concentration is equivalent to amplifying the efficacy, resulting in aggravation of adverse reactions, and even poisoning or unknown clinical consequences.
Are there any ingredients in grapefruit that affect the efficacy of the drug? Different origins, different varieties of grapefruit, the situation is not the same. Some researchers found 39 grapefruit from all over the country to determine the composition of them, and in general, most of the grapefruit's furancoumarin derivatives are not high, and the effect on the efficacy is relatively weak.
It is worth noting
Due to the different tastes, Chinese and Western ways of eating these two kinds of "grapefruit" are usually different. In China, most of us eat grapefruit directly with our bare hands, and the most favorite and common way to eat grapefruit in Europe and the United States is to beat the juice and drink the grapefruit juice. Generally speaking, eating half a grapefruit or drinking 200ml of grapefruit juice at a time has the potential ability to cause drug accumulation poisoning.
so
What medicines can't grapefruit eat with?
Pharmacist Cai Rouying listed some common drugs
Antihypertensive drugs
Grapefruit itself is rich in potassium, plus it can also inhibit liver drug enzymes, so that the blood concentration of antihypertensive drugs increases, the two may lead to a sudden drop in blood pressure, so that patients have discomfort, light dizziness, palpitation, fatigue, serious will also induce angina, myocardial infarction or stroke.
There have been media reports on such a case: elderly patients after taking antihypertensive drugs and then eat a small half grapefruit, half an hour later felt dizzy, palpitations severely, almost fainted on the way to the hospital, the doctor found that the elderly's blood pressure is very low, exceeding the limit of the conventional effect of antihypertensive drugs, and the culprit is grapefruit.
Lipid-lowering drugs
Statin lipid-lowering drugs taken with grapefruit can lead to accumulation of drugs in the body, increasing the risk of adverse reactions such as abnormal liver function and rhabdomyolysis, and may even cause kidney failure. Therefore, try not to eat grapefruit during the medication statin.
sleeping pill
Because grapefruit inhibits enzyme activity and prolongs the action time of such drugs in the body, it will aggravate the sequelae symptoms such as drowsiness and dizziness, resulting in a "hangover" phenomenon after getting up the next day. Drivers, people working at height or with high-risk precision instruments need to take special care to avoid taking the same suit.
contraceptive
Grapefruit can hinder women's absorption and utilization of contraceptives, so eating grapefruit while taking the drug may lead to contraceptive failure.
Anti-allergic drugs
Grapefruit can induce adverse reactions of anti-allergic drugs such as terfenadine, resulting in dizziness, palpitations, arrhythmias and other symptoms.
Antiarrhythmic drugs
Amiodarone, quinidine, etc. taken with grapefruit can cause torsion of the tip and be life-threatening.
Anticoagulants
Warfarin is a coumarin anticoagulant, and grapefruit enhances the anticoagulant effect of warfarin, which may cause bleeding.
immunosuppressant
Blood concentrations of cyclosporine and tacrolimus increase with the use of grapefruit. During the period of medication, if patients drink grapefruit juice for a long time, the incidence of hypertension, diabetes, hyperkalemia, and agranulocytopenia will be significantly increased.
Other medications that may be affected
Antibacterial drugs erythromycin, antiepileptic carbamazepine, antiviral drugs indinavir, and anxiolytic drugs buspirone will also interact with grapefruit.
Finally, Cai Rouying said
Eating grapefruit normally helps to reduce weight and lipids, cough and phlegm, appetize and digest food, lower blood pressure, laxative, enhance immunity, maternal health care, and prevent cardiovascular and cerebrovascular diseases.
For people who are taking medicine and love to eat grapefruit, it should be noted that grapefruit should not be taken with drugs, especially grapefruit juice. At the same time, do not expand one-sidedly, some articles on the Internet say that "grapefruit + drug = poison" is obviously too exaggerated.
In addition to grapefruit, citrus and other fruits generally do not react with drugs, but should be avoided with juices.
Source: Fujian Health Daily All-media reporter: Lin Ying
EDIT: Ice widespread
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