This Spring Festival is not easy for everyone, in fact, it is not only the front-line staff who are contributing, as the director of the Infection Department of Huashan Hospital said in an interview: "Now I want to say that each of you is a warrior, and those who stay at home and do not go out are also warriors." Our battles require the cooperation of every warrior. Whether you are a boss, an employee or a student, please cooperate with us and feel bored at home for two weeks after returning to Shanghai. When the sick people are found out, the rest of the people are safe, this strategy is boring, and it requires each of you to contribute. "We are at home now fighting the virus, waiting to suffocate the virus, we are victorious."
Every soldier is always concerned about the epidemic when they are isolated at home, and what is more concerned is whether there is a special medicine for this new crown virus pneumonia? Therefore, there will be endless news of various "special drugs".
With the efforts of medical scientists in China and even around the world, there have been many successful cases of symptomatic treatment, allowing us to see the dawn of potential new drugs or new uses of old drugs. That is to say, not only to study new drugs, but also to see if there are drugs that treat other diseases, to see if there is a role in treating new crown pneumonia, which greatly shortens the research time of effective drugs. Recently, experts from Stanford University and the University of Hong Kong jointly published a paper saying that glycyrrhizic acid may serve as a potential inhibitor of new crown pneumonia.
<h1 class="pgc-h-arrow-right" > there are currently no specific drugs</h1>
On February 5, 2020, the National Health Commission issued the "Diagnosis and Treatment Plan for Pneumonia Infected by Novel Coronavirus (Trial Fifth Edition)", which clearly pointed out that there is no confirmed effective antiviral treatment method at present.
On the one hand, Peng Zhiyong, director of the Department of Critical Care Medicine of Wuhan University Zhongnan Hospital, also published a paper on the treatment of new crown pneumonia in the famous magazine JAMA, which clearly suggested that there is no effective antiviral drug for the time being.
Because they gave most of the patients antiviral therapy as well as antibiotic treatment, the researchers concluded that no significant effect was shown.
<h1 class= "pgc-h-arrow-right" > drug target</h1>
Our human body is composed of cells, and if the virus wants to enter the cell to destroy, it is not possible to enter it casually, but it needs to be paired through the special structure on the surface of the cell (professionally called the receptor) before it can enter.
On February 3, there was an article in nature, a top international academic journal, confirming that the path of 2019-nCoV into cells is the same as that of SARS coronavirus, that is, through the angiotensin-converting enzyme 2 (ACE2) cell receptor, which lays an important foundation for subsequent epidemic prevention and control and drug research.
That is to say, the new crown virus and the SARS coronavirus are destroyed through the same channel into the cell, and after figuring this out, we have laid a good foundation for the study of new drugs, knowing that in order to fight the virus, we must find drugs that can bind to this channel (ACE2).
<h1 class="pgc-h-arrow-right" >What is glycyrrhizic acid? </h1>
Glycyrrhizic acid is the most important active ingredient from traditional Chinese medicine licorice, the update of separation and purification technology has gradually modernized the application of glycyrrhizic acid, the latest generation of glycyrrhizic acid preparations for the new oral glycyrrhizic acid (diammonium glycyrrhizinate enteric-coated capsules), as well as pure α glycyrrhizic acid preparations (magnesium isoglyrrhizinate).
<h1 class="pgc-h-arrow-right" > glycyrrhizic acid can bind to ACE2</h1>
Since ACE2 is the key molecule of this 2019-nCoV infection, ACE2 binders are expected to become the treatment for 2019-nCoV infections. At about the same time, neurosurgery experts from Stanford University School of Medicine and experts from the School of Traditional Chinese Medicine of the University of Hong Kong jointly published a paper proving that glycyrrhizic acid can bind to ACE2, so it can be concluded that glycyrrhizitic acid preparations have potential application value in preventing 2019-nCoV infection.
<h1 class="pgc-h-arrow-right">
Glycyrrhizic acid is effective in the treatment of SARS</h1>
Studies have shown that glycyrrhizic acid has a clear direct antiviral effect, can regulate immune function to exert antiviral effects, and has a clear anti-inflammatory mechanism. In 2003, there were more literature reports that glycyrrhizic acid preparations were used as an effective drug for the treatment of SARS for clinical treatment.
Multiple papers have pointed out that glycyrrhizic acid may have a certain effect on the treatment of SARS, whether it is directly antiviral or indirect antiviral;
Glycyrrhizic acid can not only inhibit the replication of the virus, but also inhibit the adsorption of the virus and infiltrate into the virus, proper monitoring and use, glycyrrhizic acid treatment SARS is effective.
At the same time, glycyrrhizic acid is not only antiviral, but also anti-inflammatory, because the virus enters the cells and promotes the production of inflammatory factors and damages the cells. And glycyrrhizic acid can block this process.
To alleviate the current outbreak, scientists have been trying to find ways to work on safer and more effective drugs and vaccines. It takes a long time to study new drugs, so this time it is from old drugs, and glycyrrhizic acid is already effective in the SARS coronavirus. At present, it has been verified by the first phase of clinical trials through screening, and it is hoped that it can be put into clinical use as soon as possible.
I am a pharmacist Xiaoping, more medication science, welcome to click on the upper right corner to pay attention, thank you Oh
Your likes, comments, and retweets are the biggest motivation to support me to continue to create.
More questions can be discussed in the comments below.
@Headline Health
@Pharmacist Lee talks about health
@Ada in Germany
#新型冠状病毒肺炎 #
#清风计划 #
bibliography:
【1】Specific ACE2 Expression in Cholangiocytes May Cause Liver Damage After 2019-nCoV Infection
[2] Diagnosis and Treatment Plan for Pneumonia Caused by Novel Coronavirus Infection (Trial Fifth Edition)
[3] Tianqing luscious (magnesium isoglyrrhizinate injection) instructions
[4] Tianqing Ganping (diammonium glycyrrhizinate enteric-coated capsules) instruction manual
【5】Magnesium isoglycyrrhizinate ameliorates radiation-induced pulmonary fibrosis by inhibiting fibroblast differentiation via the p38MAPK/Akt/Nox4 pathway