Aminotransferases are a class of enzymes that catalyze the amino conversion between amino acids and ketoacids, and are involved in the decomposition and synthesis of amino acids. There are many kinds of transaminases in the human body, and they can participate in transaminosis, of which glutamate aminotransferase and aspartate aminotransferase are the most important. Alanine aminotransferase is most active in the liver, while aspartate aminotransferase is most active in the heart muscle.
Whether it is alanine aminotransferase or alanine transaminases, it is detected by serum. When organs with high enzyme viability are damaged, the corresponding enzymes are released into the bloodstream, resulting in increased enzymatic activity in the serum, that is, an increase in the measured value. For example, if liver disease causes liver damage, the serum amino alanine aminotransferase will increase, and myocardial disease will cause myocardial damage, and the aspartame aminotransferase in the serum will increase.
Of course, because transaminases are not only present in one organ, but everything in the human body is one. Although the organs are independent of each other, they also affect each other, and it is not necessarily the disease of the organ that causes damage to the organ. Therefore, the detection of transaminases alone cannot fully reflect the occurrence and development of diseases in vivo. The so-called increased hepatitis B aminotransferase is not necessarily a disease of the liver, let alone that it is suffering from hepatitis B.
In general, the normal reference range of alanine aminotransferase is 0-50 U/L, and more than 50 is elevated. However, alanine aminotransferase is a very sensitive indicator, the same person healthy people at different times of the day may have different test results, stay up late, exercise, eat fried food, drink alcohol, cold may cause Alanine aminotransferase elevation. Therefore, it is not necessary to look at this specificity is not a very good indicator very accurately, and normal people will also go beyond the reference range and recover by resting and adjusting diet.
Of course, we can't ignore this indicator, because many diseases can be manifested through it. If the indicator is significantly higher, first think about whether you are taking medication. If so, it is possible that the liver damage caused by the drug is reversible and will recover after a period of discontinuation. Then, it is necessary to see if you have tuberculosis, biliary tract diseases, cirrhosis and other diseases. If there is none, you can reflect the recent life status and physical state with the doctor to see if the doctor recommends a two-and-a-half test for hepatitis B.
In summary, alanine aminotransferase is one of the enzymes involved in amino conversion and is the most active in the liver. Therefore, it can be used to reflect the health status of the liver, but its specificity is low, and the normal state may also show an elevated state. Therefore, it is necessary to combine the living conditions, the clinical, or the results of other items to draw conclusions.
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