Clopidogrel is a common drug after coronary heart disease, angina, myocardial infarction, cardiac bypass and stenting, and the main purpose of our choice of clopidogrel is to prevent and treat thrombotic diseases caused by platelet aggregation. But most people do not know much about this drug, so let's learn about clopidogrel today.
Clopidogrel oral is not affected by food, before or after meals can be taken, but studies have shown that taking within 15 minutes after a meal can significantly improve the bioavailability of clopidogrel, 2 hours after taking the action, continuous administration of 3 to 7 days can achieve steady-state blood concentration, stop the drug after 5 to 7 days before the coagulation function can return to normal, so clopidogrel should be discontinued 5 to 7 days before surgery. The efficacy of this drug is worth affirming, by inhibiting platelet aggregation, thereby reducing the occurrence of cardiovascular and cerebrovascular events such as myocardial infarction and stroke. Although clopidogrel has many advantages, its most common side effect is to cause a decrease in coagulation function, if there is nosebleeds, bleeding gums, ecchymosis of the skin and mucous membranes, black stools, etc., it should be treated immediately, and regularly review blood routines, prothrombin and liver and kidney function during medication. So what drugs should clopidogrel avoid taking with them?
Clopidogrel can inhibit the metabolism of repaglinide in the body, if used together, will increase the blood concentration of repaglinide, increase the risk of hypoglycemia; clopidogrel and omeprazole, esomeprazole, ketoconazole, itraconazole, erythromycin, clarithromycin combined use, will inhibit the antiplatelet activity of clopidogrel, so that its efficacy is reduced, resulting in an increased risk of thrombotic events; clopidogrel and nonsteroidal anti-inflammatory drugs such as ibuprofen, diclofenac sodium, indomethacin combined, will increase the risk of bleeding in the gastrointestinal tract, Therefore, it should be avoided together; so who does not recommend taking clopidogrel?
An allergy: allergic to clopidogrel or allergic to any component of clopidogrel should be banned;
Two patients with active bleeding or a pronounced tendency to bleed: for example, patients with peptic ulcer bleeding or intracranial hemorrhage should be contraindicated;
Contraindicated in patients with three severe liver damage;
Lactating women during pregnancy should use with caution, if necessary, consult a professional doctor. If severe allergic symptoms and intolerable side effects occur during the period of taking clopidogrel, it is necessary to stop the drug immediately and go to the hospital in time.