Microcrystalline cellulose is widely used in pharmaceutical preparations, mainly as a binder or diluent in oral tablets and capsules, in addition to a certain degree of lubrication and disintegration, so it can be used as an adsorbent, suspension, tablet and capsule diluent, disintegration agent and the like.
With the development of industrial pharmacy in China, under the joint promotion of international and domestic pharmaceutical excipient enterprises, preparation enterprises and CXO companies, the application of microcrystalline cellulose in preparations has developed steadily, and there are the following three aspects of development trends:
1. Innovative microcrystalline cellulose
According to the needs of the formulation industry, through the control and custom development of the moisture, bulk density, particle size and distribution, black spots and impurities of microcrystalline cellulose (e.g. conventional model bulk density: 02.-0.5g/cm³, increased innovation and then extended to 0.1-0.7 g/cm³), thereby improving its appearance, flowability, formability, disintegration, for direct powder pressing, wet and dry granulation.
Enterprises producing customized microcrystalline cellulose (partial)
Hunan Erkang Pharmaceutical Co., Ltd
Huzhou Prospect Pharmaceutical Co., Ltd
Anhui Shanhe Pharmaceutical Excipients Co., Ltd
Hubei Gedian Pharmaceutical Excipients Co., Ltd
Municipal Pharmaceutical Excipients Co., Ltd
Taian Cellulose Co., Ltd
Roquette Management (Shanghai) Co., Ltd
DFE Pharma
DuPont China Group Limited
Second, microcrystalline cellulose core
Because microcrystalline cellulose has excellent elastic coefficient, tensile strength, compressibility and good viscosity, and a wide range of particle sizes, it is the most commonly used excipient for the preparation of pellet cores in industry, and the microcrystalline cellulose pellet core is used to fill the capsule after coating, and it is a commonly used filler in the pellet tablet. At present, it is more used in children. Compared with the sugar pills prepared by coating, the sugar pills are easily soluble, easy to absorb water and swell, destroying the skeleton structure of the pellets, thereby affecting the slow-release effect of the pellet preparations. The microcrystalline cellulose core is not prone to collapse because of its excellent globinarization, shape deformation, compressibility and insolubleity. After 2015, foreign marketed multi-particulate children's drugs include methylphenidate, amphetamines, metoprolol and other drugs.
Enterprises providing microcrystalline cellulose cores (partial)
Yuekang Pharmaceutical Group Anhui Natural Pharmaceutical Co., Ltd
Zhuhai Dongchen Pharmaceutical Co., Ltd
Jiangsu Dongsheng Pharmaceutical Technology Co., Ltd
RedonMel (Shanghai) Fiber Trading Co., Ltd
Third, microcrystalline cellulose co-treatment
Different from the premixed excipients prepared by simple physical mixing, co-processed excipients (Co-processed excipient) are prepared by two or more kinds of pharmaceutical excipients processed by specific physical processing processes (such as spray drying, granulation, etc.) to achieve specific functions of the mixed excipients. Co-treated excipients should not form new chemical covalent bonds during processing.
The emergence of co-treatment excipients has greatly simplified the development and production operations of pharmaceutical enterprises, improved the efficiency and effectiveness of enterprises, and is selected by more and more enterprises. At present, the existing microcrystalline cellulose co-treatment on the market mainly includes: microcrystalline cellulose colloidal silica co-treatment, microcrystalline cellulose sodium co-treatment, lactose microcrystalline cellulose co-treatment, mannitol microcrystalline croscarprosilicon co-treatment, mannitol-microcrystalline cellulose-carboxymethyl cellulose-cross-linked povidone complex.
Through the microcrystalline cellulose co-treatment, the hardness can be improved, the sensitivity to water can be reduced, the fluidity can be improved, the hardness can be improved, the dissolution disintegration is presented, and it is applied to the oral collapse tablets, dry mix suspension agent, to solve the problem of the sensitivity of proprietary Chinese medicines to lubricants and so on.
Companies that can provide microcrystalline cellulose co-treatments (partial)
Anhui Shanhe Medicinal Excipients Co., Ltd.,
Jiangsu Xidian Pharmaceutical Excipients Co., Ltd.,
Yuekang Pharmaceutical Group Anhui Natural Pharmaceutical Co., Ltd.,
Jiangsu Daoning Pharmaceutical Co., Ltd.,
Huzhou Linghu Xinwang Chemical Co., Ltd.,
German American Medicine Leworth Milk House Two-in-One Company,
DuPont China Group Limited,
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