#健康明星计划 #
Omeprazole is a commonly used acid suppressant drug in the clinic, belongs to the proton pump inhibitor, easy to concentrate in an acidic environment, specifically and gastric wall cell surface H + -K + - ATPase irreversible combination, thereby inhibiting the activity of the enzyme, so that the H + in the parietal cell can not be transported to the gastric cavity, blocking the final step of gastric acid secretion, so that the gastric content in gastric juice is greatly reduced, and the gastric acid secretion caused by basal gastric acid and stimulation has a strong inhibitory effect. After medication, with the obvious decrease in gastric acid secretion, the pH in the stomach increases rapidly. Relieves heartburn and pain faster. Cure rates for duodenal ulcers are also higher and recurrence rates are lower. It is mainly used for duodenal ulcer and Dro-Ai syndrome, but can also be used for gastric ulcers, reflux esophagitis, acid-associated dyspepsia. Contract with amoxicillin and clarithromycin or with metronidazole and clarithromycin for the eradication of Helicobacter pylori.
Omeprazole is well tolerated with fewer adverse reactions. The main adverse reactions are nausea, flatulence, diarrhea, constipation, epigastric pain, etc. Rashes, elevated aminotransferases, and bilirubin also occur, generally mildly and transiently, and mostly do not affect treatment. The nervous system may have paresthesias, dizziness, headache, drowsiness, insomnia, and peripheral neuritis. It has been reported abroad that the manifestations of atrophic gastritis can be observed in gastric biopsy specimens of patients taking omeprazole for a long time. Long-term use may cause hypergastrinemia and may also lead to vitamin B12 deficiency. Animal experiments have shown that omeprazole can cause intestinal pheochromoid hyperplasia at the base of the stomach and stomach body, and gastric carcinoid carcinoid may occur with long-term medication.
Aluminum magnesium carbonate is a commonly used antacid drug in clinical practice, which can neutralize gastric acid, adsorb pepsin, inactivate pepsin, maintain gastric juice PH between 3-5, and the antacid effect is rapid, mild and long-lasting. In addition, aluminum magnesium carbonate can also stimulate the gastric mucosa to increase the synthesis of prostaglandin E2, enhance the gastric mucosal barrier function, and can also combine bile acids and adsorb hemolytic phosphatidylcholine, thereby preventing these substances from damaging and destroying the gastric mucosa. It is mainly used for acute and chronic gastritis, duodenoccalitis, gastric ulcer, duodenal ulcer, but also for gastric discomfort caused by excessive gastric acid, such as heartburn, acid reflux, nausea, vomiting, bloating and other symptomatic treatment, but also can be used for reflux esophagitis, bile reflux and prevention of gastric mucosal damage caused by nonsteroidal anti-inflammatory drugs.
Because aluminum magnesium carbonate contains two metal ions, aluminum and magnesium, it counteracts the adverse reactions of constipation and diarrhea. Only a few patients may experience gastrointestinal discomfort, dyspepsia, vomiting, increased stool frequency or mushy stools, and even diarrhea. Aluminum ions through the combination of phosphate ions, the formation of insoluble aluminum phosphate in the intestine, can not be absorbed by the gastrointestinal tract, resulting in a decrease in serum phosphate concentration, can affect bone formation, so long-term large doses of aluminum magnesium carbonate can lead to hypophosphatemia, osteoporosis and osteomalacia. Taking aluminum magnesium carbonate in people with renal insufficiency can lead to an increase in the concentration of aluminum ions in the blood, and long-term use of aluminum magnesium carbonate in people with renal failure can cause aluminum poisoning, causing psychiatric symptoms, such as nervousness, irritability, taste abnormalities, muscle twitches, fatigue and weakness.
Bismuth potassium citrate is a commonly used gastric mucosal protector in clinical practice, which can neither neutralize gastric acid nor inhibit gastric acid secretion, but under the condition of gastric juice PH, a solid bismuth oxide colloidal precipitate is formed on the surface of the ulcer or the ulcer granulation tissue, forming a protective film, thereby isolating the erosion effect of gastric acid, pepsin and food on the ulcer mucosa, and promoting the repair and healing of ulcer tissue. In addition, bismuth potassium citrate also has the effect of improving blood flow to the gastric mucosa, protecting the gastric mucosa from damage caused by drugs and alcohol. It can also be complexed with pepsin to inactivate it, and can promote mucus secretion, which has a certain effect on ulcer healing. Bismuth citrate potassium also kills Helicobacter pylori and delays the development of antibacterial resistance of Helicobacter pylori, which is beneficial for the treatment of peptic ulcer and gastritis. Mainly used in the stomach, duodenal ulcer and chronic gastritis, can effectively alleviate stomach pain, heartburn and acid reflux caused by excessive stomach acid, etc., and combined with tetracycline, amoxicillin, clarithromycin and furazolidone can improve the clearance of Helicobacter pylori.
During the administration of bismuth potassium citrate, the mouth may have an ammonia taste, and the tongue can be stained black, which is easily confused with melena; individual patients may have nausea, vomiting, constipation, loss of appetite, diarrhea and other digestive tract symptoms when taking it, which can disappear after stopping the drug. A small number of patients may have mild headaches, dizziness, insomnia, etc., but can be tolerated. Rash may occur in individual patients. Long-term medication is at risk of neurotoxicity, and bismuth encephalopathy may occur, which can precipitate osteoarthritis associated with bismuth encephalopathy, often with unilateral or bilateral shoulder pain as a precursor. Long-term use of bismuth potassium citrate in large doses can cause renal toxicity, leading to reversible renal failure.
Jinghua gastric kang is a commonly used clinical treatment of stomach diseases of proprietary Chinese medicine, the formula is the earth mustard and water mass flower, with the effect of rationalizing the cold, clearing the heat and dissolving the stasis, for the cold and heat mixture, qi stagnation and blood stasis caused by stomach swelling, pain, belching, acid return, noisy, bitter mouth. Experimental animal pharmacological studies have confirmed that Jinghua Gastric Kang can reduce gastric acid secretion, weaken pepsin activity, protect gastric mucosa, and have a strong inhibitory effect on Helicobacter pylori. It is mainly used for chronic gastritis, Helicobacter pylori-related chronic gastritis, duodenal ulcer and functional dyspepsia.
After taking Jinghua Gastric Kang, a small number of patients have adverse reactions such as nausea, vomiting, diarrhea, stomach discomfort, and rash. No long-term adverse reactions were seen, and the safety and tolerability of long-term use were good.