On October 25, the reporter learned from the People's Hospital of Wuhan University that the latest issue of the journal "Journal of the American College of Cardiology", a top journal in the international cardiovascular field, published the latest research progress of arrhythmias in the research group of Professor Hu Dan of the Cardiovascular Department of the hospital: SCN5A, which encodes the sodium ion channel of the heart, is the main pathogenic gene for early catalytic syndrome that can lead to sudden cardiac death.
This study has great clinical significance for the early detection and prevention of sudden cardiac death caused by early pleistosis syndrome.
It is estimated that the number of sudden cardiac deaths accounts for more than 80% of the total number of sudden deaths. According to Hu Dan, J-wave syndrome is a clinical syndrome characterized by ECG J-wave with fatal arrhythmias. J-wave syndrome is closely associated with sudden cardiac death, with people with J-wave syndrome having a 3- to 10-fold increased risk of sudden cardiac death, while J-wave syndrome occurs 3 to 20 times higher than in people with sudden cardiac death.
Hu Dan said that J-wave syndrome mainly contains Brugada syndrome and early fudolar syndrome. The first clinical manifestations of both can be sudden death, which seriously threatens the safety of patients' lives.
Professor Hu Dan's group found that SCN5A, which codes sodium ion channels in the heart, is the main pathogenic gene for early fute syndrome; patients with J-Wave syndrome who carry multiple SCN5A pathogenic mutations have a significantly higher risk of malignant events than patients carrying a single SCN5A mutation.
The research team also identified the first patient with fever-induced early pleus syndrome and identified the pathogenic mutation in the patient. This mutation leads to a complete loss of sodium channel function, which makes the structure of the sodium channel protein unstable and shows a negative dominant effect, which is aggravated in a febrile state.
The above research results provide a new method for accurately identifying sudden cardiac death in the early clinical stage, or may change the relevant clinical guidelines and diagnosis and treatment decisions. Hu Dan said that by screening patients for the presence of the SCN5A gene, cardiovascular physicians can actively and effectively screen out high-risk groups of early compound syndrome from the population, and then effectively prevent and control sudden cardiac death caused by early compound syndrome. (Reporter Wu Chunxin Correspondent Du Weiwei Yang Cen)
Source: Science and Technology Daily