28 combinations of vitamin C are contraindicated

Vitamin C in the clinic is mainly used for the treatment of vitamin C deficiency disease and vitamin C supplement treatment, often there are customers in order to improve immunity to buy vitamin C supplements, then vitamin C and what drugs can not be combined Everyone will remind customers? Everyone knows which drugs can not drink vitamin C?

1. Compound wood aroma aluminum magnesium and vitamin C

Compound xylemum aluminum magnesium is a gastric mucosal protector, which will interfere with the absorption and clearance of vitamins after combining with vitamin drugs, affecting the therapeutic effect of vitamins, so compound xylemum aluminum magnesium should be avoided in combination with vitamin C.

2. Sulfonamides and vitamin C

Sulfa drugs such as sulfadiazine, sulfamethoxazole and vitamin C will increase the excretion of vitamin C and reduce its therapeutic effect on the one hand; on the other hand, if the two drugs are used for a long time, large doses of vitamin C will promote the formation of sulfonamides in the kidneys, so the two drugs should be avoided in combination.

3. Sodium bicarbonate and vitamin C

Sodium bicarbonate is alkaline, vitamin C is acidic, and the combination of the two drugs will have a neutralization reaction, so that the efficacy of both drugs is reduced, so the combination of the two drugs should be avoided.

4. Erythromycin and vitamin C

Erythromycin belongs to the macrolide class of antibacterial drugs, in the alkaline environment its antibacterial effect will increase with the increase of PH value, and vitamin C is acidic, after the combination of the two erythromycin in an acidic environment will be a large number of decomposition and destruction, affecting its antibacterial effect, so erythromycin should not be combined with vitamin C.

5. Vitamin B and vitamin C

Vitamin B is an amphoteric compound whose oxidation is greater than reductivity. Vitamin C has strong reducivity, when vitamin C and vitamin B are combined with redox reaction, vitamin C will promote vitamin B destruction into reductive vitamin B and lose efficacy. Therefore, vitamin B should not be used in combination with vitamin C.

6. Vitamin B12 and vitamin C

Taking large doses of vitamin C will destroy the synthesis of vitamin B12 in the liver, so people with vitamin B12 deficiency should not consume vitamin C in large quantities to avoid anemia.

7. Vitamin K and vitamin C

Vitamin C has strong reducibility, while vitamin K has a certain oxidation, redox reaction will occur after the two drugs are compatible, vitamin K is easy to cause failure, so the two drugs should not be combined.

8. Calcium and vitamin C

Taking large doses of vitamin C promotes calcium to form crystals in the kidneys, so vitamin C should be avoided in combination with calcium.

9. Ciprofloxacin and vitamin C

Vitamin C reduces the oral bioavailability of ciprofloxacin and reduces the absorption of ciprofloxacin, thereby reducing its efficacy. Therefore, when the two drugs are combined, the dose of ciprofloxacin should be adjusted as appropriate or switched to ofloxacin for treatment.

10. Deferoxamine and vitamin C

Vitamin C can promote the complexation of deferoxamine to iron, increase the excretion of urine iron, and reduce its efficacy, so the dose of deferoxamine can be appropriately increased during the combination of the two drugs.

11. Propranolol and vitamin C

After propranolol is taken at the same time as vitamin C, vitamin C will promote a significant decrease in the average peak plasma concentration of propranolol and the area under the drug time curve, affecting the therapeutic effect of propranolol. Therefore, it is recommended to stagger the time of taking propranolol with vitamin C or to increase the dose of propranolol according to the needs of the patient's condition.

12. Methylcholine acetate and vitamin C

Methylcholine acetate is an Mcholine receptor agonist that increases bronchial secretion by contracting bronchial smooth muscles. However, after combining with vitamin C, because vitamin C affects the metabolism of arachidonic acid and interferes with the production of prostaglandins, it can reduce the airway reaction caused by methylcholine acetate, so it is necessary to appropriately increase the dosage of methylcholine during the combination of the two drugs, so as not to affect the treatment effect.

13. Ferrous fumarate and vitamin C

After ferrous fumarate is combined with vitamin C, vitamin C can promote the absorption of ferrous fumarate, but it will also increase the incidence of gastrointestinal reactions, so it is necessary to pay close attention to the occurrence of gastrointestinal reactions during the combination of the two drugs, and if necessary, reduce the dose in time.

14. Ethinyl estradiol and vitamin C

Oral administration of 1 g of vitamin C can increase the bioavailability of a single oral dose of ethinyl estradiol to 60%-70%, so it is necessary to pay attention to the dose adjustment when the two drugs are combined.

15. Anticoagulant drugs and vitamin C

Oral administration of large doses of vitamin C can interfere with the anticoagulant effect of drugs such as heparin and warfarin sodium, shortening the prothrombin time, so the dose of vitamin C should be adjusted at any time according to the anticoagulant effect during the combination.

16. Acetylcysteine and vitamin C

Vitamin C is an acidic drug, which will reduce its efficacy when combined with acetylcysteine, so it is necessary to pay close attention to the therapeutic effect of acetylcysteine during the combination, and if necessary, adjust the dosage or change other drugs for symptomatic treatment.

17. Folic acid and vitamin C

Vitamin C is a partial acidic drug, and when taken at the same time as folic acid, vitamin C will inhibit the absorption of folic acid in the gastrointestinal tract, prompting the rapid decomposition of folic acid in an acidic environment, resulting in a decrease in the efficacy of folic acid. Therefore, when used in the treatment of anemia in clinical applications, it is recommended that the two drugs be taken at staggered times, and an interval of 1 hour is recommended.

18. Dacronin and vitamin C

Vitamin C tablets are crushed and applied to the wound surface will play a role in wound healing, dacronin has a certain analgesic effect, but after the combination of the two will be due to the difference in PH value, the dissociation value of dacronin will be affected, resulting in a delay in its action time, so the two drugs are not recommended to be combined.

19. Tetracycline antibacterial drugs and vitamin C

Tetracycline antibacterial drugs such as tetracycline, oxytetracycline, and chlortetracycline can increase the excretion of vitamin C after being combined with vitamin C, so the dose of vitamin C should be appropriately increased during the combination of the two drugs.

20. Aspirin and vitamin C

Aspirin contains salicylic acid by liver drug enzyme metabolism will produce salicylate, these salicylates are mainly excreted through the kidneys, the amount of excretion is susceptible to the PH value of urine, of which the excretion rate of salicylate in acidic urine is less than 5%, and vitamin C is having the effect of acidifying urine, so after aspirin is combined with vitamin C, it will lead to a decrease in the excretion of salicylate, which is easy to cause salicylate poisoning. From this point of view, aspirin and vitamin C should not be used in combination.

21. Barbiturates and vitamin C

Phenobarbital, barbiturates, pentobarbital and other barbiturates will increase the excretion of vitamin C after being combined with vitamin C, so the dose of vitamin C should be appropriately supplemented when long-term application.

22. Theophylline drugs and vitamin C

Vitamin C can reduce the oral absorption rate of theophylline drugs and weaken their asthmatic effect, so if there is malabsorption of theophylline drugs when oral vitamin C and theophylline drugs are taken orally, the use of rapid absorption tablets or liquid preparations should be considered instead, so as not to affect the treatment effect.

23. Pentazil and vitamin C

Pentaxidine is a psychotropic drug, when combined with vitamin C, can reduce the content of vitamin C in the body, in addition to the two drugs at the same time orally, vitamin C will reduce the effectiveness of perphenazine, weaken the antipsychotic effect of pentaxidine, so the two drugs should not be combined.

24. Phenytoin sodium and vitamin C

Phenytoin aqueous solution is alkaline, in an acidic environment can precipitate phenytoin precipitation, while vitamin C injection is acidic, if the two injection preparations are injected together, will precipitate white precipitation, so the injection of the two drugs should not be compatible. In addition, for the oral preparation of the two drugs, after the combination of the oral preparation of vitamin C and the oral preparation of phenytoin in the body, vitamin C is easy to hinder the absorption of phenytoin in the body, thereby reducing the bioavailability of phenytoin and weakening its efficacy, so if it is necessary to use oral preparations in combination, the change in the blood concentration of phenytoin sodium should be closely monitored, and the dosage of phenytoin sodium should be adjusted in time.

25. Mitomycin and vitamin C

When mitomycin and vitamin C are administered intravenously at the same time, vitamin C can reduce the therapeutic effect of mitomycin, so the two drugs should not be used together.

26. Metronidazole and vitamin C

After intravenous drip of metronidazole injection and vitamin C injection, the color of the solution will become darker, and the content of metronidazole in the mixture will be significantly reduced. However, there was no significant change in color after dilution of the high concentration metronidazole injection and then added to the vitamin C injection for 24 hours. However, for safety reasons, it is recommended that the two drugs be inleted separately and intractally.

27. Norfloxacin and vitamin C

Norfloxacin injection has a certain degree of oxidation, while vitamin C has a strong reducibility, and the redox reaction will occur after the simultaneous intravenous drip of the two drugs, and the intolerable particles will be precipitated, increasing the probability of adverse reactions.

28. Levodopa + vitamin C

Vitamin C can interfere with the absorption of levodopa in the body and reduce the therapeutic effect of levodopa, so the therapeutic dose of levodopa should be appropriately increased when the two drugs are combined.

It can be seen that vitamin C is not something that can be used if you want to use, and improper use will not only not enhance the therapeutic effect, but will bring adverse reactions or reduce the therapeutic effect. Therefore, it should be correctly understood that vitamin C, scientific vitamin C supplementation, usually adults and women in the first trimester of pregnancy supplement the dose of vitamin C supplementation is 100mg per day, women in the middle and third trimester of pregnancy and lactating women need to supplement the dose of vitamin C per day for 130mg, when colds can also be appropriately supplemented vitamin C, but should not be taken for a long time, generally 3-5 days is appropriate.

In addition to the need to pay attention to the contraindications to the combination of vitamin C oral preparations, it is also necessary to pay attention to the injection of drugs that are not suitable for compatibility, vitamin C because of its strong reducibility, as well as the nature of instability, it is easy to accelerate the decomposition of the light, so it is necessary to avoid light preservation and it is recommended to be individually infused intravenously.

Vitamin C looks like an ordinary drug, there are many compatibility contraindications that need to be paid attention to, and special attention needs to be paid to in clinical applications to achieve safe, effective and reasonable use.