Daddy eats antihypertensive drugs and then gluttonous grapefruit, who knows dizziness chest tightness suffers from low blood pressure, beware! Grapefruit should not be taken with these medicines

Jimu news reporter Zheng Jingjing

Correspondent Yu Yi Bo Yunna Liu Shanshan

At present, it is the season when a large number of grapefruit is listed, many citizens love to eat grapefruit to moisten the fire, however, the reporter interviewed doctors and pharmacists in many hospitals in Jiangcheng on the 26th to understand that if the public eats a large number of grapefruit when taking some drugs, it may cause the efficacy of the drug to be affected, and even affect health.

After taking antihypertensive drugs and eating a lot of grapefruit, Daddy actually had low blood pressure

Daddy Liu lives in Hankou, has a history of hypertension for more than ten years, has been taking medicine on time, and his blood pressure is well controlled.

Recently, the weather has been dry, and Daddy Liu always feels dry mouth and fire. The son bought a few large grapefruit for Daddy Liu to lower the fire. One morning last week, after Liu Daddy took antihypertensive drugs, he ate most of the grapefruit while watching TV, and then he felt chest tightness, panic, and fatigue. The family quickly measured Liu Daddy's blood pressure, indicating that the high pressure was only 96 mm Hg, and the low pressure was only 50 mm Hg.

Because His father has been looking for Zhang Peng, deputy chief physician of the Department of Cardiovascular Medicine, wuhan Traditional Chinese Medicine Hospital, the mobile phone has the doctor's phone number, and the family quickly called to ask Dr. Zhang Peng. Zhang Peng inquired in detail on the phone, and initially judged that his father may have eaten a lot of grapefruit shortly after taking antihypertensive drugs, so he had low blood pressure. If the symptoms are not treated in time, it may induce stroke or myocardial infarction, and it is recommended that the patient's family send the father to the hospital in time. After timely medical treatment, after symptomatic treatment, Daddy's blood pressure returned to normal.

Why does eating grapefruit cause low blood pressure? Dad and his family were puzzled by this. In this regard, Zhang Peng, deputy chief physician of the Department of Cardiovascular Medicine of Wuhan Traditional Chinese Medicine Hospital, said that the active ingredient in grapefruit can inhibit the activity of certain metabolic enzymes in the liver and reduce the ability of the human body to metabolize drugs. When the metabolism declines, the effective amount of the drug can actually enter the blood increases, if the patient drinks grapefruit juice or eats more grapefruit while eating antihypertensive drugs, it may lead to taking the same antihypertensive drug, but the actual antihypertensive effect is enhanced, so it may lead to a decrease in blood pressure.

6 types of drugs should not be taken with grapefruit, otherwise it may endanger health

Nowadays, grapefruit is a seasonal fruit, like Daddy Liu, because it is not uncommon to eat grapefruit shortly after taking the medicine, resulting in the effect of the drug being affected.

Mr. Fang, 56, had a kidney transplant a few years ago, has been taking immunosuppressant drugs, and regularly goes to the hospital to check the blood to see if the drug concentration in the blood is qualified. However, the last time he went to the hospital for a check-up, he was found to have a high concentration of drugs in his blood, almost to the alert value. After the doctor asked him whether he had taken medicine according to the doctor's advice, whether he had taken other medicines, what food he had eaten in the past few days, and after ruling out the reasons for the first two items, Mr. Fang told the doctor that he had recently bought a lot of grapefruit at home, and he would eat most of them every day. The doctor's preliminary diagnosis should be that the grapefruit has affected the efficacy of the drug, so that Mr. Fang should not eat the grapefruit first, and then recheck after 3 days. Sure enough, when the re-examination was carried out after 3 days, Mr. Fang's examination results had returned to normal.

What other medications may affect the efficacy of grapefruit when eaten together? On the 26th, Liu Yangcong, a clinical pharmacist in the Pharmacy Department of Wuhan First Hospital, said in an interview with reporters that antihypertensive drugs (mainly antihypertensive drugs with "dipalion" in the name), lipid-lowering drugs, anti-anxiety or sedatives, anti-allergic drugs (such as cistimamine, terfenadine), contraceptives, immunosuppressants, etc., can not be eaten with grapefruit. For example, when lipid-lowering drugs such as simvastatin and atorvastine are taken with grapefruit, it will lead to the accumulation of drugs in the body, increasing the probability of liver damage, the risk of adverse reactions such as rhabdomyolysis, and even cause kidney failure; some anxiolytic drugs such as diazepam, midazolam, etc. cannot be eaten with grapefruit, because grapefruit will prolong the residence time of such sedative hypnotics in the body, resulting in sequelae symptoms such as dizziness and drowsiness; antiallergic drugs (such as cistimil, terfenadine) cannot be taken with grapefruit, because grapefruit is consumed after taking such drugs , will aggravate the adverse reactions of anti-allergic drugs to the heart, liver and gastrointestinal tract, etc.; grapefruit will hinder the absorption and utilization of contraceptives in women, so eating grapefruit during taking drugs may lead to contraceptive failure; immunosuppressants (such as cyclosporine) can not be eaten with grapefruit, because the blood drug concentration increases, adverse reactions increase, increase liver and kidney toxicity. However, he also stressed that under normal circumstances, grapefruit must eat a certain amount to affect the efficacy.

Deng Aiping, director of the Department of Pharmacy of Wuhan Central Hospital, also suggested that for safety reasons, it is best to avoid eating grapefruit or drinking grapefruit juice for 3 days before taking the drug and within 6 hours after taking the drug. If the public does not know which drugs cannot be taken with grapefruit, it is best to consult a doctor or pharmacist to find out so as not to affect health.

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