Guide:
With the continuous penetration of the cognitive concept of scientific pet raising in China, pet owners are more and more aware of the importance of microbial groups to pet health. Among them, the gastrointestinal microbiota, as the largest microbial community in pets, has a more significant impact on their health. Research data show that 70% of the immunity of dogs and cats comes from the intestines, and 80% of the detoxification and metabolism are completed by the intestines. It has been scientifically and medically proven that 90% of diseases are related to an imbalance in the intestinal flora.
Therefore, how to solve pet gastrointestinal problems is very important for pet health. In recent years, the intestinal microbiota transplantation technology, which has shined in the field of human medicine, may provide a new solution to this pain point.
According to pet industry news, on May 14, the unveiling ceremony of the cooperation between Sichuan Anaerobic Biotechnology Co., Ltd. and Sichuan Agricultural University was officially held. At the event, the two parties jointly established the first "Pet Intestinal Microbiota Transplantation Specialty" in China and established the "China Pet Intestinal Bacteria Transplantation Specialty Alliance", in order to bring more scientific and efficient solutions to the field of pet medical care and pet intestinal health.
The details are as follows:
Jointly build the first pet intestinal microbiota transplantation specialty in China
Explore new solutions in the field of pet healthcare
At the unveiling ceremony, Dr. Cheng Lei, chief scientist of Sichuan Anaerobic Biology, first delivered a speech. Cheng Lei said that in recent years, the construction of anaerobic biological strain resource bank has developed from "one bank" to "four banks", opened up the whole industrial chain of strain screening, isolation, preservation, testing, evaluation and production, and fully mastered the core technology of "from bacteria to medicine", and reached a new height of "independent research and development and clinical application" in the field of research and application in the field of microorganisms.
In the context of the era of great health, pet health and people's physical and mental health have been closely linked. With the transformation of pets' social roles to family members and the upgrading of people's pursuit of healthy lifestyles, the layout of pet health track has become an important part of the strategic planning of anaerobic biology.
Among them, gastrointestinal health is the core of pet health, and it is also a pain point that pet owners are more concerned about at this stage. As one of the most famous methods of intestinal microbiota restoration in the field of human medicine, FMT (Fecal Microbiota Transplantation) has been shown to have significant effects on both humans and companion animals. In the "Technical Specifications for National Medical Service Projects" released in September 2023, the National Health Commission also officially included intestinal microbiota transplantation (FMT) as a new project for medical services.
Anaerobic biology believes that FMT, which has a significant improvement effect on intestinal problems, should be "cross-border" expanded and applied to the field of pet health, not only to fill the gap in the domestic pet FMT market, but also to become an innovative pet health solution, and promote the development of the pet intestinal industry in a more scientific and efficient direction.
To this end, Anaerobic Biology and Sichuan Agricultural University have set up the first characteristic department in China focusing on intestinal health management and the implementation of advanced clinical therapies such as intestinal bacteria transplantation for dogs and cats by integrating the superior resources of the school and enterprise in terms of R&D platform, technology accumulation and professional talent team.
It is expected that in the future, the pet intestinal microbiota transplantation department will become a more professional, accurate and effective pet intestinal health management center. As the first pet FMT technology service provider in China, Sichuan Anaerobic Biology will also develop more new technologies and new products with a more professional and scientific attitude, improve the quality of life of pets, and help pet owners scientifically protect the intestinal health of pets.
Accelerate technological innovation and application
Jointly solve the problems in the field of pet intestinal health
Talking about the signing of the cooperation, Professor Zhong Zhijun of the Teaching Animal Hospital of Sichuan Agricultural University also said that Sichuan Agricultural University is a national "211 Project" key construction university and a national "double first-class" construction university with biotechnology as its characteristics, agricultural science and technology as its advantages, and multidisciplinary coordinated development.
The Teaching Animal Hospital is the largest animal hospital in the western region and the most powerful in technology, and was selected as the first "China's Top 100 Pet Hospitals" and "Sichuan Five-Star Animal Hospital", and has won high praise from the majority of pet owners and the public with its good medical ethics and superb medical skills.
The joint establishment of the "Pet Intestinal Flora Transplantation Specialist" and the "China Pet Intestinal Bacteria Transplantation Specialty Alliance" are to meet the needs of a more comprehensive and higher level of pet health, and also to help build a first-class animal hospital in China and realize the deep integration of "production, learning and research". Sichuan Anaerobic Bio has a rich resource library of pet strains, which can use metagenomic sequencing technology to analyze the change trend of pet intestinal flora, and provide more accurate and effective pet health solutions for pets.
△Professor Zhong Zhijun of the Teaching Animal Hospital of Sichuan Agricultural University delivered a speech
In the future, Sichuan Anaerobic Biology and Sichuan Agricultural Teaching Animal Hospital will learn from their respective strengths, accelerate technological innovation and application, jointly solve the problems in the field of pet intestinal health, and provide more professional and personalized intestinal health management solutions for pets.
From intestine to field to intestine
How effective is FMT in practice?
Talking about the practical landing and application of intestinal microbiota transplantation (FMT) in the pet industry, anaerobic biology officially pointed out that the microorganisms in the intestine are interdependent as a comprehensive functional organization, and one or several probiotics cannot replace all the functions of the intestinal flora. In contrast, FMT can improve the intestinal ecology more comprehensively.
Especially in the face of complex intestinal environmental disorders and intestinal flora imbalances, FMT can bring a complete healthy microbiota environment except for specific probiotics, and the treatment effect of pets suffering from intestinal diseases may be more efficient and robust than probiotics or antibiotic treatment.
To put it simply, FMT is to transplant the functional flora of healthy donors into the intestines of sick pets to rebuild the intestinal microecology, so as to achieve the treatment of enteritis, diarrhea, soft stools, intestinal ulcers, indigestion and other diseases inside and outside the intestines.
At the same time, FMT also plays an important role in the health of the body and the immune system:
- 1. Microbiota reconstruction: increase microbial diversity, adjust the proportion of intestinal flora, and compete for intestinal niche;
- 2. Metabolic improvement: increase short-chain fatty acids, reduce intestinal pH and redox potential, regulate secondary bile acids, and secrete bacteriocins;
- 3. Immunoregulation: stimulate cells to secrete mucin, antimicrobial peptides and IgA, promote T cell activation, Th1 cell differentiation, leukocyte adhesion, and inhibit the excessive inflammatory response of the intestine;
- 4. Gut-brain/liver axis: through the gut-brain axis and gut-liver axis, the amount and activity of neurotransmitters and vasoactive substances are regulated, and the function of distal organs is improved.
At present, anaerobic biology has created a strict donor screening mechanism, and has launched two series: FMT intestinal bacteria capsules and FMT enema bacterial liquid. According to reports, the core ingredients of these two series are the same, and both can provide customized services to ensure that the transplanted intestinal flora matches the needs of the recipient.
The difference is that FMT enteric capsules are more convenient to use, and the form of oral enteric-coated capsules "from the intestine to the field to the intestines" not only avoids the invasion of gastric acid, but also has a higher user acceptance; The FMT enema liquid will not be disturbed by external factors, and the remodeling effect is better, but the use of this series needs to be operated under the guidance of a professional veterinarian, and the process is relatively cumbersome.
According to unpublished data, in clinical practice, anaerobic organisms have collected 200+ FMT application cases, and the comprehensive improvement rate of clinical feedback of FMT for dogs and cats is as high as more than 90%.
These data also indicate the effectiveness of FMT in pet gut health problems. With the in-depth research of intestinal microbiota and the continuous innovation of technology, it is expected that FMT will become an important means of intestinal microecological regulation and intestinal health management of pets in the future. In this regard, the pet industry will also continue to pay attention.
About pet FMT
FMT (FMT for cats, FMT for dogs) is made from feces directly from healthy cats or dogs, contains the entire intestinal flora (at least 500 species and 1000 strains), and these bacteria have adapted well and colonized the intestines of cats or dogs.
FMT can be performed with a colonoscopy or enema, but for cats or dogs, anesthesia and sedation are usually required and are expensive. FMT capsule is an oral capsule that contains the entire intestinal flora of a cat or dog that has been carefully screened, multi-stage processed, and freeze-dried, which has the advantages of safe ingredients, easy to take, and rapid feedback on the use effect.
About Sichuan Anaerobic Biology
Sichuan Anaerobic Biology is committed to the research and development of innovative drugs for therapeutic biological products (microecological live bacteria) and microecological products in the field of health, the company has a human microbial strain resource bank covering multiple regions across the country and more than 2,000 species and more than 200 pet strains of more than 1,000 species, the species diversity is at the leading level in China, and has mastered the core technology of the whole chain of strain screening + isolation + preservation + detection + evaluation + production.
The human microbiome is a new paradigm for disease treatment, prevention and rehabilitation, and has been called "one of the world's top 10 scientific breakthroughs" since 2013. Since its establishment, Sichuan Anaerobic Bio has focused on the development of microecological drugs and the layout of the microbial industry, and has successively promoted multi-directional business models such as microecological industrialization development, FMT project (intestinal bacteria transplantation), scientific research service cooperation, etc., to provide customers with one-stop probiotic scientific research cooperation services such as joint development of strains, culture and separation of microbiota, process optimization, intestinal bacteria transplantation, and research and development of consumer products.