Author: Department of Neurology, Huashan Hospital, Fudan University, Vascular Group
As a high-profile international conference in the field of stroke, the 10th European Stroke Organisation Conference (ESOC) will be held in Basel, Switzerland from May 15 to 17, to exchange the latest research results of scholars from all over the world in the form of offline conferences.
In this meeting, a total of eight studies from the Huashan stroke team were selected for oral presentations and poster exchanges. In order to let you know the highlights of the research in advance, the editor has compiled a brief content of these studies as a warm-up for the conference, and I hope to bring you new research perspectives and thinking. In addition, during the conference, we will also pay attention to and report on the blockbuster clinical studies in real time, so as to learn with you, so stay tuned for our follow-up reports!
Oral Presentation
Willow
Ph.D., University of Melbourne, Australia, attending physician of Huashan Hospital affiliated to Fudan University, his main research direction is the mechanism and diagnosis and treatment of acute ischemic stroke. He undertook a youth project of the National Natural Science Foundation of China and a youth fund project of metabolomics of cerebrovascular diseases of the Chinese Stroke Association, and published 7 SCI articles and 2 core journals as the first author.
A real-world study of intravenous thrombolysis with tenecteplase within the time window of acute ischemic stroke
Randomised controlled trials have shown that tenecteplase (TNK) is non-inferior to the current classical thrombolytic drug alteplase within the time window for acute ischemic stroke, and the risk of bleeding is comparable. Intravenous thrombolytic therapy for TNK has been carried out in several stroke centers in mainland China, but its efficacy and safety are unclear. The purpose of this study was to evaluate the efficacy and safety of TNK in the real world in China by comparing the propensity score matching method with patients using alteplase using data from 18 central time windows in China.
Oral Presentation
Li Siyuan
He is a resident physician at the Standardized Training Base for Neurology Residents in Huashan Hospital, Fudan University, and a member of the Acute Ischemic Stroke Emergency Team of the Department of Neurology of Huashan Hospital. His main research interests are acute ischemic stroke, acute imaging and acute diagnosis and treatment.
Venous drainage improves clinical neurological outcomes by attenuating post-infarct microcirculatory disorders
Venous drainage (VO), as a venous component of the cerebral collateral cascade (CCC), is considered a surrogate marker of microcirculatory effectiveness because it is downstream of the microcirculation. In this study, patients with anterior circulation macrovascular occlusion within 24 hours of onset of the Chinese Multimodal Imaging Consortium for Acute Ischemic Stroke (CHABLIS) were included to explore whether the positive effect of venous drainage on clinical neurological outcomes is mediated by the reduction of microcirculatory disorders after infarction.
Moderated Poster
He Zhijiao
He is a 2022 Ph.D. in the Vascular Group of the Department of Neurology of Huashan Hospital Affiliated to Fudan University, and a member of the Acute Ischemic Stroke Emergency Team of the Department of Neurology of Huashan Hospital. His main research interests are diagnosis and treatment of acute ischemic stroke and imaging analysis.
Imaging markers related to early neurological deterioration in patients with mild stroke and macrovascular disease
Due to the establishment of good collateral services, some patients with acute ischemic stroke and severe stenosis or occlusion of large vessels present with mild neurological deficits. However, previous studies have shown that 20% to 40% of these patients still have early neurological deterioration (END). The purpose of this study was to explore the imaging markers that predict the development of END in patients with severe stenosis or occlusion of large blood vessels in the anterior circulation using baseline multimodal imaging.
Poster
Liu Xinyu
He is currently studying for a Ph.D. in the Vascular Group of the Department of Neurology of Huashan Hospital affiliated to Fudan University, and a member of the Acute Ischemic Stroke Emergency Team of the Department of Neurology of Huashan Hospital. He is mainly engaged in the imaging clinical research of multimodal CT of acute ischemic stroke and its guided reperfusion therapy.
Correlation between zonal perfusion parameters and hemorrhagic transformation after acute ischemic stroke reperfusion therapy
Intravenous thrombolysis and endovascular thrombectomy are the most effective treatments for acute ischemic stroke, while hemorrhagic transformation (HT) is a common complication of stroke reperfusion therapy. It is thought that there are differences in vulnerability between different anatomical areas of the brain. The purpose of this study was to investigate the correlation between perfusion parameters and HT at baseline in patients with acute ischemic stroke, so as to provide more basis and decision-making support for the judgment and treatment of acute stage.
Poster
Hong Lan
M.D., Resident Physician of the Department of Neurology, Department of Neurology, Huashan Hospital, Fudan University, and member of the Emergency Team for Acute Ischemic Stroke, Department of Neurology, Huashan Hospital. His main research interests are acute ischemic stroke, acute imaging and acute diagnosis and treatment. At present, he has published 7 SCI articles and 1 Chinese core journal as the first author. He has won 1 "Cerebrovascular Disease Youth Innovation Fund" of the China International Medical Exchange Foundation, 1 special grant from the China Postdoctoral Science Foundation (in front of the station), 1 National Natural Youth Fund, and has won the Young Investigator Travel Award of the International Stroke Conference, the Outstanding Paper of the National Neurology Academic Conference, and the Outstanding Graduate of Shanghai.
Recanalization time predicts the prognosis of patients with tenecteplase thrombolysis
Previous studies have demonstrated that the vascular cumulative recanalization rate of alteplase thrombolysis increases with time. The aim of this study was to characterize the repassage process after thrombolysis of tenecteplase and to explore a suitable time point for vascular recanalization assessment. In this study, patients with acute ischemic stroke with vascular occlusion who were thrombolyzed with tenecteplase alone in an international multicenter cohort were included, and the recanalization time was calculated according to the growth rate of the infarct core, and the patients were divided into patients without recanalization, earlier recanalization ( There were 4 groups <1 hour), delayed recanalization (1~6 hours) and late recanalization (6~24 hours). It was found that the proportion of cumulative vascular recanalization increased with the increase of time after thrombolysis, while the proportion of ineffective recanalization also increased. The clinical prognosis of patients with recanalization within 6 hours was significantly better than that of patients without recanalization, and the bleeding risk of patients with recanalization within 6~24 hours was significantly higher than that of patients without recanalization. At 1, 6, and 24 hours, vascular recanalization at 6 hours after thrombolysis had the largest area under the curve (AUC) and the most balanced sensitivity and specificity for prognosis.
Poster
Zhang Shufan
He is currently a Ph.D. candidate in the Department of Neurology, Huashan Hospital, Fudan University, and his main research direction is the etiology and mechanism of stroke in young people.
Polygenic risk scores were used to predict cerebral arterial dissection in the Chinese population
Cerebral artery dissection (CeAD) is a rare but serious condition. The cause remains unknown. Risk factors for CeAD include hereditary connective tissue disease, hyperhomocysteinemia, migraine, recent infection, and neck massage, but none of these factors are specific enough to explain the pathology of CeAD. A growing number of studies have shown that arterial dissection is genetically predisposed, and this study explored the single nucleotide polymorphisms (SNPs) of CeAD in the Chinese population for the first time by genome-wide association analysis, and calculated the polygenic risk score (PRS) based on the SNPs of all independent risks, and demonstrated that PRS was significantly associated with the incidence of CeAD in the test set and validation set.
Poster
Zhu Bing'er
He is currently a master's student in the vascular group of the Department of Neurology of Huashan Hospital affiliated to Fudan University, and a member of the emergency team of acute ischemic stroke in the Department of Neurology of Huashan Hospital. His main research interests are the diagnosis and treatment of craniocarotid artery dissection.
Exploration of treatment options for ischemic stroke due to craniocarotid artery dissection
Craniocarotid artery dissection is an important and common cause of stroke in young people, and most ischemic events occur within 14 days after dissection, so it is essential for early antithrombotic therapy in this population, but there is a lack of a complete treatment system. Based on the Huashan craniocarotid artery dissection cohort, this study aimed to provide clinicians with individualized antithrombotic therapy based on the clinical prognosis and imaging characteristics of patients.
Poster
Relaxation
Ph.D., graduated from Fudan University with an eight-year program in clinical medicine. He is currently an attending physician in the Department of Neurology, Huashan Hospital, Fudan University, and is committed to clinical and basic research on cerebrovascular diseases. He went to Melbourne, Australia to participate in the clinical training course for neurologists in China and Australia. He has published many articles in domestic and foreign journals and presided over a youth project of the National Natural Science Foundation of China.
Effect of edaravone dexprenol on hemorrhagic transformation after thrombolytic therapy
Hemorrhagic transformation is a major complication after intravenous thrombolytic therapy for acute ischemic stroke. Current treatments to reduce the risk of hemorrhagic transformation after thrombolysis in ischemic stroke are limited. The purpose of this study was to investigate whether edaravone dexpresanol can reduce the hemorrhagic transformation after intravenous thrombolytic therapy in patients with acute ischemic stroke and the effect of the drug on blood-brain barrier permeability.
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